All Outputs (323)

Outcomes after emergency appendicectomy in patients with liver cirrhosis: a population-based cohort study from England (2023)
Journal Article

Introduction The mortality risk after appendicectomy in patients with liver cirrhosis is predicted to be higher than in the general population given the associated risk of perioperative bleeding, infections and liver decompensation. This population-... Read More about Outcomes after emergency appendicectomy in patients with liver cirrhosis: a population-based cohort study from England.

A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach (2023)
Journal Article

Individuals developing stroke have varying clinical characteristics, demographic, and biochemical profiles. This heterogeneity in phenotypic characteristics can impact on cardiovascular disease (CVD) morbidity and mortality outcomes. This study uses... Read More about A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach.

Application and Extension of the Alcohol Recovery Narratives Conceptual Framework (2023)
Journal Article

Recovery narratives are personal stories of health problems and recovery. A systematic review proposed a conceptual framework characterising alcohol misuse recovery narratives, consisting of eight principal dimensions, each with types and subtypes. T... Read More about Application and Extension of the Alcohol Recovery Narratives Conceptual Framework.

Developing evidence-based patient-focused learning materials to support health behaviour change for people living with psoriatic arthritis (2023)
Journal Article

Objectives: In psoriatic arthritis (PsA), self-management is important for patient function and quality of life. Behaviour change can be difficult, patients could benefit from high-quality support to initiate change. Our aim was to codesign the proje... Read More about Developing evidence-based patient-focused learning materials to support health behaviour change for people living with psoriatic arthritis.

Cause-specific mortality in patients with alcohol-related liver disease in Denmark: a population-based study (2023)
Journal Article

Background Knowledge of the causes of death is essential to prevent premature death in alcohol-related liver disease (ALD). We examined cause-specific mortality, including death due to specific cancers, in 15 years after diagnosis of ALD. Methods... Read More about Cause-specific mortality in patients with alcohol-related liver disease in Denmark: a population-based study.

Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard (2023)
Journal Article

Introduction: Bronchopulmonary dysplasia (BPD) is associated with adverse long-term respiratory and neurodevelopmental outcomes. No recent studies examined the changing respiratory management and outcomes, particularly severe BPD, across a whole popu... Read More about Respiratory management and outcomes in high-risk preterm infants with development of a population outcome dashboard.

The facilitators and barriers to improving functional activity and wellbeing in people with dementia: A qualitative study from the Process Evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED) (2023)
Journal Article

Background. The PRomoting Activity, Independence and Stability in Early Dementia (PrAISED) study delivered an exercise and functional activity programme to participants living with dementia. A Randomised Controlled Trial (RCT) showed no measurable be... Read More about The facilitators and barriers to improving functional activity and wellbeing in people with dementia: A qualitative study from the Process Evaluation of Promoting Activity, Independence and Stability in Early Dementia (PrAISED).

Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study (2023)
Journal Article

The long-term (>5y) outcomes following liver transplantation (LT) have not been extensively reported. The aim was to evaluate outcomes of LT recipients who have survived the first 5 years. A multicenter retrospective analysis of prospectively collect... Read More about Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study.

Long-term outcomes (beyond 5 years) of liver transplant recipients - a transatlantic multicentre study (2023)
Journal Article

The long-term (>5 year) outcomes following liver transplantation (LT) have not been extensively reported. The aim was to evaluate outcomes of LT recipients who have survived the first 5 years. A multicentre retrospective analysis of prospectively... Read More about Long-term outcomes (beyond 5 years) of liver transplant recipients - a transatlantic multicentre study.

The impact of ageing on adults with cerebral palsy (2023)
Journal Article

Background Cerebral palsy (CP) is one of the most common neurological disorders in children and results in lifelong physical impairments. Adults with CP have approximately the same life expectancy as their non-disabled peers, so helping them to stay... Read More about The impact of ageing on adults with cerebral palsy.

Evaluating the UK's first national prescribing assessment for GPs in training using an online survey (2023)
Journal Article

Background GP trainees may not have experienced a systematic and comprehensive education in safe prescribing. Therefore, a self-assessment prescribing review was developed. Aim To determine whether the assessment was feasible, had face validity, a... Read More about Evaluating the UK's first national prescribing assessment for GPs in training using an online survey.

The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review (2023)
Journal Article

Background: Topical corticosteroids (TCS) are a first-line treatment for eczema, but there are concerns about their safety when used long-term. Objectives: To systematically review adverse effects associated with longer-term use of TCS for eczema. Me... Read More about The long-term safety of topical corticosteroids in atopic dermatitis: A systematic review.

Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models (2023)
Journal Article

Background: Methods to identify patients at increased risk of oesophageal cancer are needed to better identify those for targeted screening. We aimed to derive and validate novel risk prediction algorithms (CanPredict) to estimate the 10-year risk of... Read More about Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models.

Emollients for preventing atopic eczema: Cost‐effectiveness analysis of the BEEP trial (2023)
Journal Article

Background Recent discoveries have led to the suggestion that enhancing skin barrier from birth might prevent eczema and food allergy. Objective To determine the cost‐effectiveness of daily all‐over‐body application of emollient during the firs... Read More about Emollients for preventing atopic eczema: Cost‐effectiveness analysis of the BEEP trial.

Evaluating the effect of child home safety training upon three family support practitioner groups: a mixed-methods study (2023)
Journal Article

Aims: Unintentional injuries in the home contribute substantially to preschool child morbidity and mortality. Practitioners such as health visitors, family mentors and children’s centre staff are well-positioned to facilitate child injury prevention... Read More about Evaluating the effect of child home safety training upon three family support practitioner groups: a mixed-methods study.

Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP): a qualitative study exploring trial team’s facilitators and challenges in conducting a feasibility trial in India (2023)
Journal Article

Background In India, around 77 million people are at high risk of developing type 2 diabetes mellitus (T2DM). Yoga interventions can be effective in preventing T2DM. We conducted a feasibility randomized controlled trial (RCT) in India, and the inte... Read More about Yoga Programme for Type 2 Diabetes Prevention (YOGA-DP): a qualitative study exploring trial team’s facilitators and challenges in conducting a feasibility trial in India.

Forming a consensus opinion to inform long COVID support mechanisms and interventions: a modified Delphi approach. (2023)
Journal Article

Background: Current approaches to support patients living with post-COVID condition, also known as Long COVID, are highly disparate with limited success in managing or resolving a well-documented and long-standing symptom burden. With approximately 2... Read More about Forming a consensus opinion to inform long COVID support mechanisms and interventions: a modified Delphi approach..

The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap (2023)
Journal Article

Background Core outcome sets (COS) are consensus-driven sets of minimum outcomes that should be measured and reported in all clinical trials. COS aim to reduce heterogeneity in outcome measurement and reporting, and selective outcome reporting. Imple... Read More about The Harmonising Outcome Measures for Eczema (HOME) implementation roadmap.

The relationship between reported daily nicotine dose from NRT and daily cigarette consumption in pregnant women who smoke in an observational cohort study (2023)
Journal Article

Introduction For non-pregnant people unable to quit smoking, the NHS recommends nicotine replacement therapy (NRT) for smoking reduction. This is not recommended during pregnancy due to concerns about higher nicotine intake than smoking alone. We inv... Read More about The relationship between reported daily nicotine dose from NRT and daily cigarette consumption in pregnant women who smoke in an observational cohort study.

Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study (2023)
Journal Article

Objectives To quantify mortality rates for patients successfully treated for hepatitis C in the era of interferon-free, direct acting antivirals and compare these rates with those of the general population. Design Population based cohort study.... Read More about Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study.