All Outputs (90)

The interrater and test–retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis (2023)
Journal Article

Introduction: Quantitative Sensory Testing (QST) modalities used to assess central pain mechanisms require different protocols in people with different musculoskeletal conditions. Objectives: We aimed to explore the possible effects of musculo... Read More about The interrater and test–retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis.

Chronic back pain prevalence at small area level in England - the design and validation of a 2-stage static spatial microsimulation model (2023)
Journal Article

Spatially disaggregated estimates provide valuable insights into the nature of a disease. They highlight inequalities, aid public health planning and identify avenues for further research. Spatial microsimulation is advantageous in that it can be use... Read More about Chronic back pain prevalence at small area level in England - the design and validation of a 2-stage static spatial microsimulation model.

COVID-19 in a Dutch Nursing Home: A Longitudinal Retrospective Care-Home-Level Case Study on Infection Rate, Survival Rate, and Daily Functioning (2023)
Journal Article

During the pandemic, nursing homes in the Netherlands were heavily affected by COVID-19. This study assesses the impact of COVID-19 on infection rate, survival rate, and daily functioning over the course of two years among residents of a nursing home... Read More about COVID-19 in a Dutch Nursing Home: A Longitudinal Retrospective Care-Home-Level Case Study on Infection Rate, Survival Rate, and Daily Functioning.

Impact of COVID-19 on Home Care Provision: A qualitative study (2023)
Journal Article

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2023)
Working Paper

Background Sulfasalazine induced cytopenia, nephrotoxicity, and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend three monthly monitoring blood-tests indefinitely while others recommend stopping monitoring after one ye... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Gut-joint axis in knee synovitis: gut fungal dysbiosis and altered fungi–bacteria correlation network identified in a community-based study (2023)
Journal Article

Objectives: Knee synovitis is a highly prevalent and potentially curable condition for knee pain; however, its pathogenesis remains unclear. We sought to assess the associations of the gut fungal microbiota and the fungi–bacteria correlation network... Read More about Gut-joint axis in knee synovitis: gut fungal dysbiosis and altered fungi–bacteria correlation network identified in a community-based study.

Influence of central aspects of pain on self-management in people with chronic low back pain (2023)
Journal Article

Objective: This observational study investigated whether central aspects of pain are associated with self-management domains in individuals with chronic low back pain (CLBP) undertaking a pain management program. Methods: Individuals with CLBP provid... Read More about Influence of central aspects of pain on self-management in people with chronic low back pain.

Management of acute cervical spinal cord injury in the non‐specialist intensive care unit: a narrative review of current evidence (2023)
Journal Article

Each year approximately one million people suffer spinal cord injury, which has significant physical, psychosocial and economic impacts on patients and their families. Spinal cord rehabilitation centres are a well-established part of the care pathway... Read More about Management of acute cervical spinal cord injury in the non‐specialist intensive care unit: a narrative review of current evidence.

Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis. (2023)
Journal Article

Background: Knee osteoarthritis is a complex condition with established risk factors such as female sex, increasing age and body mass index, reduced quadriceps muscle strength and knee injury. Despite known associated risks, the role and behaviour of... Read More about Association between quadriceps tendon elasticity and neuromuscular control in individuals with knee osteoarthritis..

Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial (2023)
Journal Article

Background: Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial.

Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial (2023)
Journal Article

Background Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial.

‘Smart’ BLE wearables for digital contact tracing in care homes during the COVID-19 pandemic—a process evaluation of the CONTACT feasibility study (2023)
Journal Article

Background: Rapid and mass transmission of the SARS-CoV-2 virus amongst vulnerable people led to devastating effects from COVID-19 in care homes. The CONTACT intervention introduced Bluetooth Low Energy ‘smart’ wearable devices (BLE wearables) as a b... Read More about ‘Smart’ BLE wearables for digital contact tracing in care homes during the COVID-19 pandemic—a process evaluation of the CONTACT feasibility study.

Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process (2023)
Journal Article

Background Care Home residents live with frailty and multiple long-term conditions. Their medical management is complex and specialised. We set out to develop a list of core competencies for doctors providing medical care in long-term care homes. M... Read More about Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process.

Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study (2023)
Journal Article

Objective The pathogenesis of hand osteoarthritis (OA) remains unknown. Hyperuricaemia, which is related to inflammation, may play a role in hand OA, but evidence is lacking. In a large population-based study, we examined the association between hyp... Read More about Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study.

Long-term psychological outcomes following stroke: the OX-CHRONIC study (2023)
Journal Article

Background Stroke survivors rate longer-term (> 2 years) psychological recovery as their top priority, but data on how frequently psychological consequences occur is lacking. Prevalence of cognitive impairment, depression/anxiety, fatigue, apathy... Read More about Long-term psychological outcomes following stroke: the OX-CHRONIC study.

Spotlight on the academic multidisciplinary team: proposals from the 3rd NIHR Newcastle BRC Academic Geriatric Medicine Workshop (2023)
Journal Article

High-quality care for older people is best delivered by multidisciplinary teams involving a range of professions. Similarly, if research evidence is to effectively inform practice, it needs to be designed and executed by teams that are both multidisc... Read More about Spotlight on the academic multidisciplinary team: proposals from the 3rd NIHR Newcastle BRC Academic Geriatric Medicine Workshop.

Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery (2023)
Journal Article

Objective The effectiveness of liraglutide 3.0 mg (Saxenda) therapy to induce weight loss among obese patients prior to bariatric surgery remains uncertain. Methods Clinical data was retrospectively obtained from patients with prediabetes (HbA1c... Read More about Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery.

Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts (2023)
Journal Article

Background: Since gut microbiome dysbiosis can cause inflammatory disorders by affecting host metabolism, we postulate that the gut microbiome and related metabolites could play a role in hand osteoarthritis. We characterised gut microbiome-related m... Read More about Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts.

Osteoarthritis pain phenotypes: How best to cut the cake? (2023)
Journal Article

Evaluation of a COVID‐19 fundamental nursing care guideline versus usual care: The COVID‐NURSE cluster randomized controlled trial (2023)
Journal Article

Aim: To evaluate the impact of usual care plus a fundamental nursing care guideline compared to usual care only for patients in hospital with COVID‐19 on patient experience, care quality, functional ability, treatment outcomes, nurses' moral distress... Read More about Evaluation of a COVID‐19 fundamental nursing care guideline versus usual care: The COVID‐NURSE cluster randomized controlled trial.