All Outputs (164)

Development of a Job Retention Vocational Rehabilitation Intervention for People with Multiple Sclerosis Following the Person-Based Approach (2024)
Journal Article

Objective To describe the process of developing a job retention vocational rehabilitation intervention for people with multiple sclerosis. Design We used the person-based approach, to develop interventions through an iterative process incorporat... Read More about Development of a Job Retention Vocational Rehabilitation Intervention for People with Multiple Sclerosis Following the Person-Based Approach.

The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England (2024)
Journal Article

Introduction The association between chronic pain and frailty might indicate that pain is an independent driver of frailty but might alternatively be explained by inclusion within frailty identification tools of morbidities that commonly lead to chr... Read More about The association of painful and non-painful morbidities with frailty: a cross sectional analysis of a cohort of community dwelling older people in England.

Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats (2024)
Journal Article

Melatonin exhibits potential for pain relief and long-term safety profile. We examined the analgesic effects of oral melatonin on osteoarthritis (OA) and investigated the underlying mechanism. Using data from a UK primary care database, we conducted... Read More about Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats.

Peer mentoring for people with acquired brain injury – a systematic review (2024)
Journal Article

Introduction: Over 100 million people worldwide live with disabilities resulting from an acquired brain injury (ABI). ABI survivors experience cognitive and physical problems and require support to resume an active life. They can benefit from support... Read More about Peer mentoring for people with acquired brain injury – a systematic review.

2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice (2024)
Journal Article

Objective: To formulate evidence-based recommendations and overarching principles on the use of imaging in the clinical management of crystal-induced arthropathies (CiAs). Methods: An international task force of 25 rheumatologists, radiologists, meth... Read More about 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article

Background Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping m... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health (2024)
Journal Article

Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by ba... Read More about Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health.

Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage (2024)
Journal Article

Background: Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, in the UK context, issues to be considered before t... Read More about Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.

Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis (2024)
Journal Article

Objective: Sodium-glucose cotransporter-2 inhibitors (SGLT2Is) reduce cardio-metabolic and renal outcomes in patients with type 2 diabetes (T2D) but their efficacy and safety in older or frail individuals remains unclear. Methods: We searched PubMed,... Read More about Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis.

Feasibility of delivering a randomized controlled trial of weighted blanket intervention to help agitation and disturbed sleep after brain injury (2024)
Journal Article

Sleep disturbance and agitation are common after acquired brain injury (ABI). Weighted blankets may help these symptoms in other conditions, but have not been trialed in ABI. We aimed to determine acceptability and feasibility of weighted blankets to... Read More about Feasibility of delivering a randomized controlled trial of weighted blanket intervention to help agitation and disturbed sleep after brain injury.

The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study (2024)
Journal Article

Background: The COVID-19 pandemic led to approximately half of the working population in the United Kingdom being unable to work temporarily. This study aims to understand the employment needs and experiences of people with multiple sclerosis (MS) in... Read More about The Impact of COVID-19 on the Employment of People With Multiple Sclerosis: A Multi-Methods Study.

Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults (2024)
Journal Article

Although muscle atrophy may partially account for age-related strength decline, it is further influenced by alterations of neural input to muscle. Persistent inward currents (PIC) and the level of common synaptic inputs to motoneurons influence neuro... Read More about Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults.

A scoping review of remote group-based psychological interventions for people after transient ischemic attack and stroke (2024)
Journal Article

Background Mental health and quality of life are commonly affected following a stroke or Transient Ischemic Attack (TIA) diagnosis, although many people are discharged without clear information about their psychological impact. Evidence suggests psy... Read More about A scoping review of remote group-based psychological interventions for people after transient ischemic attack and stroke.

The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK (2024)
Journal Article

Background: Current recommendations advocate the achievement of an optimal glucose control (HbA1c < 69mmol/mol) prior to elective surgery to reduce risks of peri- and post-operative complications, but the relevance for this glycaemic threshold prior... Read More about The Effects of Preoperative Glycaemic Control (HbA1c) on Bariatric and Metabolic Surgery Outcomes: Data from a Tertiary-Referral Bariatric Centre in the UK.

Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study (2024)
Journal Article

Osteochondral grafts are used for repair of focal osteochondral lesions. Autologous grafts are the gold standard treatment; however, limited graft availability and donor site morbidity restrict use. Therefore, there is a clinical need for different g... Read More about Functional performance of a bi-layered chitosan-nano-hydroxyapatite osteochondral scaffold: a pre-clinical in vitro tribological study.

The effectiveness of cupping therapy on low back pain: A systematic review and meta-analysis of randomized control trials (2024)
Journal Article

This study aims to investigate the effectiveness of cupping therapy on low back pain (LBP). Medline, Embase, Scopus and WANFANG databases were searched for relevant cupping RCTs on low back pain articles up to 2023. A complementary search was manuall... Read More about The effectiveness of cupping therapy on low back pain: A systematic review and meta-analysis of randomized control trials.

Comparing Self-Reported Running Distance and Pace With a Commercial Fitness Watch Data: Reliability Study (2024)
Journal Article

Background There is substantial evidence exploring the reliability of running distance self-reporting and GPS wearable technology, but there are currently no studies investigating the reliability of participant self-reporting in comparison to GPS wea... Read More about Comparing Self-Reported Running Distance and Pace With a Commercial Fitness Watch Data: Reliability Study.

Chronic back pain prevalence at small area level in England - the design and validation of a 2-stage static spatial microsimulation model (2023)
Journal Article

Spatially disaggregated estimates provide valuable insights into the nature of a disease. They highlight inequalities, aid public health planning and identify avenues for further research. Spatial microsimulation is advantageous in that it can be use... Read More about Chronic back pain prevalence at small area level in England - the design and validation of a 2-stage static spatial microsimulation model.

The interrater and test–retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis (2023)
Journal Article

Introduction: Quantitative Sensory Testing (QST) modalities used to assess central pain mechanisms require different protocols in people with different musculoskeletal conditions. Objectives: We aimed to explore the possible effects of musculo... Read More about The interrater and test–retest reliability of 3 modalities of quantitative sensory testing in healthy adults and people with chronic low back pain or rheumatoid arthritis.

COVID-19 in a Dutch Nursing Home: A Longitudinal Retrospective Care-Home-Level Case Study on Infection Rate, Survival Rate, and Daily Functioning (2023)
Journal Article

During the pandemic, nursing homes in the Netherlands were heavily affected by COVID-19. This study assesses the impact of COVID-19 on infection rate, survival rate, and daily functioning over the course of two years among residents of a nursing home... Read More about COVID-19 in a Dutch Nursing Home: A Longitudinal Retrospective Care-Home-Level Case Study on Infection Rate, Survival Rate, and Daily Functioning.