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All Outputs (164)

Understanding the burden of chronic back pain: a spatial microsimulation of chronic back pain at small area level across England (2023)
Journal Article

Purpose: Chronic back pain (CBP)carries a significant burden. Understanding how and why CBP prevalence varies spatially, as well as the potential impact of policies to decrease CBP would prove valuable for public health planning. This study aims to s... Read More about Understanding the burden of chronic back pain: a spatial microsimulation of chronic back pain at small area level across England.

Inflammatory and Noninflammatory Disease Activity in Rheumatoid Arthritis: The Effect of Pain on Personalized Medicine (2023)
Journal Article

Disease activity in rheumatoid arthritis (RA) is often described in terms of inflammation, although noninflammatory mechanisms are also integral to the disease. Pain is the most important symptom for many people with RA, and is therefore a key compo... Read More about Inflammatory and Noninflammatory Disease Activity in Rheumatoid Arthritis: The Effect of Pain on Personalized Medicine.

How do stroke early supported discharge services achieve intensive and responsive service provision? Findings from a realist evaluation study (WISE) (2023)
Journal Article

Background: Stroke Early Supported Discharge (ESD) involves provision of responsive and intensive rehabilitation to stroke survivors at home and it is recommended as part of the stroke care pathway. Core components have been identified to guide the d... Read More about How do stroke early supported discharge services achieve intensive and responsive service provision? Findings from a realist evaluation study (WISE).

Whole-body MRI for cancer surveillance in ataxia–telangiectasia: A qualitative study of the perspectives of people affected by A-T and their families (2023)
Journal Article

Background/Objectives: Ataxia–telangiectasia (A-T) is a complex inherited disease associated with an increased risk of malignancy. Surveillance guidelines have demonstrated significant health benefits in other cancer predisposition syndromes. However... Read More about Whole-body MRI for cancer surveillance in ataxia–telangiectasia: A qualitative study of the perspectives of people affected by A-T and their families.

Dynamic assessment of the double contour sign by ultrasonography helps to distinguish between gout and calcium pyrophosphate deposition disease (2023)
Journal Article

Objective To test whether the double contour (DC) sign has a different dynamic behaviour in gout and calcium pyrophosphate deposition (CPPD) and whether the dynamic assessment of the DC sign increases its accuracy in gout diagnosis. Methods This cros... Read More about Dynamic assessment of the double contour sign by ultrasonography helps to distinguish between gout and calcium pyrophosphate deposition disease.

The co-design of an exercise-based, lifestyle intervention for people with venous leg ulcers; a self-care, expert-supported strategy for a chronic condition (2023)
Journal Article

Exercise is recommended as an adjunct treatment, alongside compression therapy to increase venous leg ulcer (VLU) wound healing times, however, there are no published programmes available that support patients to exercise at home on their own. To dev... Read More about The co-design of an exercise-based, lifestyle intervention for people with venous leg ulcers; a self-care, expert-supported strategy for a chronic condition.

The Effectiveness of Zinc Supplementation in Taste Disorder Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2023)
Journal Article

Introduction. Food taste and flavour affect food choice and acceptance, which are essential to maintain good health and quality of life. Reduced circulating zinc levels have been shown to adversely affect the taste, but the efficacy of zinc supplemen... Read More about The Effectiveness of Zinc Supplementation in Taste Disorder Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Evaluating current guidelines for cardiopulmonary resuscitation using an integrated computational model of the cardiopulmonary system (2023)
Journal Article

Objective: We aimed to use a high-fidelity computational model that captures key interactions between the cardiovascular and pulmonary systems to investigate whether current CPR protocols could potentially be improved. Methods: We developed and valid... Read More about Evaluating current guidelines for cardiopulmonary resuscitation using an integrated computational model of the cardiopulmonary system.

Experiences and understanding of apathy in people with neurocognitive disorders and their carers: a qualitative interview study (2023)
Journal Article

Background apathy, defined as reduced goal-directed activity, interests and emotion, is highly prevalent in neurocognitive disorders (NCDs). Apathy has important consequences for the individuals who experience it and their carers, yet the lived expe... Read More about Experiences and understanding of apathy in people with neurocognitive disorders and their carers: a qualitative interview study.

Patient characteristics, anaesthetic workload and techniques in the UK: an analysis from the 7th National Audit Project (NAP7) activity survey (2023)
Journal Article

Detailed contemporary knowledge of the characteristics of the surgical population, national anaesthetic workload, anaesthetic techniques and behaviours are essential to monitor productivity, inform policy and direct research themes. Every 3–4 years,... Read More about Patient characteristics, anaesthetic workload and techniques in the UK: an analysis from the 7th National Audit Project (NAP7) activity survey.

Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study (2023)
Journal Article

Osteoarthritis (OA) is the most common arthritis affecting synovial joints such as knees and hips of millions of people globally. Usage-related joint pain and reduced function are the most common symptoms experienced by people with OA. To improve pai... Read More about Serum Metabolome Analysis Identified Amino-Acid Metabolism Associated With Pain in People With Symptomatic Knee Osteoarthritis – A Cross-Sectional Study.

“We’re Not Going to Be as Prepared”: A Qualitative Study of Healthcare Trainees’ Experiences after One Year of the COVID-19 Pandemic (2023)
Journal Article

The COVID-19 pandemic had significant impacts on the mental health and academic experiences of healthcare trainees. Building on findings from earlier in the pandemic, we explore the impacts on healthcare trainees after a sustained pandemic period of... Read More about “We’re Not Going to Be as Prepared”: A Qualitative Study of Healthcare Trainees’ Experiences after One Year of the COVID-19 Pandemic.

A mixed-methods feasibility case series of a job retention vocational rehabilitation intervention for people with multiple sclerosis (2023)
Journal Article

Purpose: To ascertain the feasibility and acceptability of delivering a job retention vocational rehabilitation intervention [MSVR] for people with multiple sclerosis (pwMS) in a community setting. Secondary objectives included determining whether MS... Read More about A mixed-methods feasibility case series of a job retention vocational rehabilitation intervention for people with multiple sclerosis.

Obesity and its associated factors in older nursing home residents in three European countries—Secondary data analyses from the “International Prevalence Measurement of Care Quality” (2023)
Journal Article

Background: The prevalence of obesity has risen in recent decades and reached epidemic proportions worldwide. The proportion of those living with obesity is also increasing in nursing homes. This could impact the nursing care required, equipment and... Read More about Obesity and its associated factors in older nursing home residents in three European countries—Secondary data analyses from the “International Prevalence Measurement of Care Quality”.

Is Vaccination Against COVID-19 Associated With Inflammatory Bowel Disease Flare? Self-Controlled Case Series Analysis Using the UK CPRD (2023)
Journal Article

INTRODUCTION: To investigate the association between vaccination against coronavirus disease 2019 (COVID-19) and inflammatory bowel disease (IBD) flare. METHODS: Patients with IBD vaccinated against COVID-19 who consulted for disease flare be... Read More about Is Vaccination Against COVID-19 Associated With Inflammatory Bowel Disease Flare? Self-Controlled Case Series Analysis Using the UK CPRD.

How people with knee pain understand why their pain changes or remains the same over time: A qualitative study (2023)
Journal Article

Objectives Guidelines recommend knee osteoarthritis pain management based on biopsychosocial mechanisms. Treatment adherence and effectiveness may be affected if there is a mismatch between patient perspectives and treatment focus. We therefore exam... Read More about How people with knee pain understand why their pain changes or remains the same over time: A qualitative study.

Contrast‐enhanced ultrasound repeatability for the measurement of skeletal muscle microvascular blood flow (2023)
Journal Article

Contrast-enhanced ultrasound (CEUS) can be used to directly assess skeletal muscle perfusion. However, its repeatability over time has not yet been validated and therefore its use in longitudinal measures (i.e., exploring the impact of a chronic inte... Read More about Contrast‐enhanced ultrasound repeatability for the measurement of skeletal muscle microvascular blood flow.

Loss of muscle mass in the immediate post-operative period is associated with inadequate dietary protein and energy intake (2023)
Journal Article

Despite the implementation of ‘Enhanced Recovery After Surgery’ (ERAS) protocols, major abdominal surgery is still associated with significant and detrimental losses of muscle mass and function in the post-operative period. Although ERAS protocols ad... Read More about Loss of muscle mass in the immediate post-operative period is associated with inadequate dietary protein and energy intake.

Clinical academics' experiences during the COVID-19 pandemic: a qualitative study of challenges and opportunities when working at the clinical frontline (2023)
Journal Article

Objectives: This study explored the experiences of clinical academics during the COVID-19 pandemic. The aim was to identify challenges and benefits associated with returning to, or increasing hours at, the clinical frontline. Design: Qualitative data... Read More about Clinical academics' experiences during the COVID-19 pandemic: a qualitative study of challenges and opportunities when working at the clinical frontline.