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Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications (2024)
Journal Article
Woods, J. G., Achten, E., Asllani, I., Bolar, D. S., Dai, W., Detre, J. A., …the ISMRM Perfusion Study Group. (2024). Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications. Magnetic Resonance in Medicine, 92(2), 469-495. https://doi.org/10.1002/mrm.30091

Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision-making. This guidelines article provides a comprehensive overview of quantitative... Read More about Recommendations for quantitative cerebral perfusion MRI using multi‐timepoint arterial spin labeling: Acquisition, quantification, and clinical applications.

Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study (2024)
Journal Article
Thomas, S., Littleboy, K., Foubert, J., Nafilyan, V., Bannister, N., Routen, A., Morriss, R., Khunti, K., Armstrong, N., Gray, L. J., & Gordon, A. L. (2024). Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study. Age and Ageing, 53(4), Article afae071. https://doi.org/10.1093/ageing/afae071

Background: Older people with frailty are at risk of harm from immobility or isolation, yet data about how COVID-19 lockdowns affected them are limited. Falls and fractures are easily measurable adverse outcomes correlated with frailty. We investigat... Read More about Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study.

Real‐world persistence of multiple sclerosis disease‐modifying therapies (2024)
Journal Article
Tallantyre, E. C., Dobson, R., Froud, J. L. J., St John, F. A., Anderson, V. M., Arun, T., Buckley, L., Evangelou, N., Ford, H. L., Galea, I., George, S., Gray, O. M., Hibbert, A. M., Hu, M., Hughes, S. E., Ingram, G., Kalra, S., Lim, C. E., Mathews, J. T. M., McDonnell, G. V., …Robertson, N. P. (2024). Real‐world persistence of multiple sclerosis disease‐modifying therapies. European Journal of Neurology, 31(7), Article e16289. https://doi.org/10.1111/ene.16289

Background and purpose: Treatment persistence is the continuation of therapy over time. It reflects a combination of treatment efficacy and tolerability. We aimed to describe real‐world rates of persistence on disease‐modifying therapies (DMTs) for p... Read More about Real‐world persistence of multiple sclerosis disease‐modifying therapies.

Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2) (2024)
Journal Article
Blair, G., Appleton, J. P., Doubal, F. N., Mhlanga, I. I., Woodhouse, L. J., Bath, P. M., & Wardlaw, J. M. (2024). Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2). Stroke and Vascular Neurology, https://doi.org/10.1136/svn-2023-003022

Cerebral small vessel disease (cSVD) causes lacunar stroke (25% of ischaemic strokes), haemorrhage, dementia, physical frailty, or is 'covert', but has no specific treatment. Uncertainties about the design of clinical trials in cSVD, which patients t... Read More about Design of trials in lacunar stroke and cerebral small vessel disease: review and experience with the LACunar Intervention Trial 2 (LACI-2).

Used to be a dime, now it’s a dollar: R-SPiN keyword predictability revisited 40 years on (2024)
Journal Article
Whitley, A., Naylor, G., & Hadley, L. V. (2024). Used to be a dime, now it’s a dollar: R-SPiN keyword predictability revisited 40 years on. Journal of Speech, Language, and Hearing Research, 67(4), 1229-1242. https://doi.org/10.1044/2024_JSLHR-23-00615

Purpose: Almost 40 years after its development, in this article, we reexamine the relevance and validity of the ubiquitously used Revised Speech Perception in Noise (R-SPiN) sentence corpus. The R-SPiN corpus includes “high-context” and “low-conte... Read More about Used to be a dime, now it’s a dollar: R-SPiN keyword predictability revisited 40 years on.

Predictability of intelligence and age from structural connectomes (2024)
Journal Article
Kopetzky, S. J., Li, Y., Kaiser, M., & Butz-Ostendorf, M. (2024). Predictability of intelligence and age from structural connectomes. PLoS ONE, 19(4), Article e0301599. https://doi.org/10.1371/journal.pone.0301599

In this study, structural images of 1048 healthy subjects from the Human Connectome Project Young Adult study and 94 from ADNI-3 study were processed by an in-house tractography pipeline and analyzed together with pre-processed data of the same subje... Read More about Predictability of intelligence and age from structural connectomes.

Typology of employers offering line manager training for mental health (2024)
Journal Article
Blake, H., Hassard, J., Dulal-Arthur, T., Wishart, M., Roper, S., Bourke, J., …Thomson, L. (2024). Typology of employers offering line manager training for mental health. Occupational Medicine, 74(3), 242-250. https://doi.org/10.1093/occmed/kqae025

Background Mental ill health has a high economic impact on society and employers. National and international policy advocates line manager (LM) training in mental health as a key intervention, but little is known about employer training provisions. A... Read More about Typology of employers offering line manager training for mental health.

Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK (2024)
Journal Article
Khan, K., Hall, C. L., Babbage, C., Dodzo, S., Greenhalgh, C., Lucassen, M., …Hollis, C. (2024). Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK. Pilot and Feasibility Studies, 10(1), Article 53. https://doi.org/10.1186/s40814-024-01475-7

Background : A serious game called SPARX (Smart, Positive, Active, Realistic, X-factor thoughts), originally developed in New Zealand and incorporating cognitive behavioural therapy (CBT) principles, has been shown to help reduce symptoms of depressi... Read More about Precision computerised cognitive behavioural therapy (cCBT) for adolescents with depression: a pilot and feasibility randomised controlled trial protocol for SPARX-UK.

The impact of the COVID-19 pandemic on children and adolescent mental health inpatient service use in England: An interrupted time-series analysis of national patient records (2024)
Journal Article
Tsiachristas, A., Holland, J., Guo, B., Chitsabesan, P., Sayal, K., & Pari, A. A. A. (2024). The impact of the COVID-19 pandemic on children and adolescent mental health inpatient service use in England: An interrupted time-series analysis of national patient records. BJPsych Open, 10(2), Article e69. https://doi.org/10.1192/bjo.2024.9

Background: During the initial phases of the COVID 19 pandemic children and young people (CYP) faced significant restrictions. The virus and mitigation approaches significantly impacted how health services could function, and be safely delivered.... Read More about The impact of the COVID-19 pandemic on children and adolescent mental health inpatient service use in England: An interrupted time-series analysis of national patient records.

Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service (2024)
Journal Article
Radford, S. J., Abdul-Aema, B., Tench, C., Leighton, P., Coad, J., & Moran, G. W. (2024). Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service. Scandinavian Journal of Gastroenterology, 59(6), 683-689. https://doi.org/10.1080/00365521.2024.2330588

Background: Imaging is used to monitor disease activity in small bowel Crohn’s disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, pati... Read More about Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.

Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol (2024)
Journal Article
Griffiths, S. L., Murray, G. K., Logeswaran, Y., Ainsworth, J., Allan, S. M., Campbell, N., …Upthegrove, R. (2024). Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol. JMIR Research Protocols, 13(1), Article e50177. https://doi.org/10.2196/50177

Background: Early intervention in psychosis (EIP) services are nationally mandated in England to provide multidisciplinary care to people experiencing first-episode psychosis, which disproportionately affects deprived and ethnic minority youth. Quali... Read More about Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol.

“I’m pulling through because of you”: injured workers’ perspective of workplace factors supporting return to work under the Saskatchewan Workers’ Compensation Board scheme (2024)
Journal Article
Lewis, I., & Houdmont, J. (2024). “I’m pulling through because of you”: injured workers’ perspective of workplace factors supporting return to work under the Saskatchewan Workers’ Compensation Board scheme. Frontiers in Rehabilitation Sciences, 5, Article 1373888. https://doi.org/10.3389/fresc.2024.1373888

Background: Research demonstrates sustained return to work (RTW) by individuals on medical leave is influenced by personal and job resources and job demands. Relatively few studies have been conducted in the workers’ compensation context that is know... Read More about “I’m pulling through because of you”: injured workers’ perspective of workplace factors supporting return to work under the Saskatchewan Workers’ Compensation Board scheme.

“Until the decision to admit the patient is made...”: Experiences of clinicians working in the inpatient-community mental health care pathway for young people in the UK (2024)
Journal Article
Shah, A., Holland, J., Briley, P. M., & Majumder, P. (in press). “Until the decision to admit the patient is made...”: Experiences of clinicians working in the inpatient-community mental health care pathway for young people in the UK. British Journal of Healthcare Management,

Objective The raised complexity, severity, and risk level of referrals to Child and Adolescent Mental Health Service (CAMHS) has put serious pressure on bed availability in adolescent psychiatry hospitals, which resulted in lengthy admission process... Read More about “Until the decision to admit the patient is made...”: Experiences of clinicians working in the inpatient-community mental health care pathway for young people in the UK.

Bayesian Inference for Non-linear forward model by using a VAE-based neural network structure (2024)
Journal Article
Zhang, Y., Zheng, J.-Q., & Chappell, M. (2024). Bayesian Inference for Non-linear forward model by using a VAE-based neural network structure. IEEE Transactions on Signal Processing, 72, 1400-1411. https://doi.org/10.1109/TSP.2024.3374115

In this paper, a Variational Autoencoder (VAE) based framework is introduced to solve parameter estimation problems for non-linear forward models. In particular, we focus on applications in the field of medical imaging where many thousands of model-b... Read More about Bayesian Inference for Non-linear forward model by using a VAE-based neural network structure.

Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting (2024)
Journal Article
McCabe, A., Martin, S., Rowe, S., Shah, J., Morgan, P. S., Borys, D., & Panek, R. (2024). Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting. European Radiology Experimental, 8(1), Article 27. https://doi.org/10.1186/s41747-024-00429-1

Background: Tumour hypoxia is a recognised cause of radiotherapy treatment resistance in head and neck squamous cell carcinoma (HNSCC). Current positron emission tomography-based hypoxia imaging techniques are not routinely available in many centres.... Read More about Oxygen-enhanced MRI assessment of tumour hypoxia in head and neck cancer is feasible and well tolerated in the clinical setting.

Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST (2024)
Journal Article
MacDonald, A. S., McConnachie, A., Dickie, D. A., Bath, P. M., Forbes, K., Quinn, T., …Dawson, J. (2024). Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST. Journal of Human Hypertension, 38, 307-313. https://doi.org/10.1038/s41371-024-00906-5

Blood Pressure Variability (BPV) is associated with cardiovascular risk and serum uric acid level. We investigated whether BPV was lowered by allopurinol and whether it was related to neuroimaging markers of cerebral small vessel disease (CSVD) and c... Read More about Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST.

Disclosing non-visible disabilities in educational workplaces: a scoping review (2024)
Journal Article
Hassard, J., Yildrim, M., Thomson, L., & Blake, H. (2024). Disclosing non-visible disabilities in educational workplaces: a scoping review. British Medical Bulletin, 150(1), 23-41. https://doi.org/10.1093/bmb/ldae004

a sizable proportion of the working population has a disability that is not visible. Many choose not to disclose this at work, particularly in educational workplaces where disability is underrepresented. A better understanding of the barriers and fac... Read More about Disclosing non-visible disabilities in educational workplaces: a scoping review.

Group concept mapping to facilitate participatory design of the web-based Pain-at-Work Toolkit (2024)
Presentation / Conference Contribution
Blake, H., Greaves, S., Abbott-Fleming, V., & Somerset, S. (2024, March). Group concept mapping to facilitate participatory design of the web-based Pain-at-Work Toolkit. Presented at 18th International Technology, Education and Development Conference, Valencia, Spain

Concept mapping is increasingly being used as an approach to enhance the development of evidence-based public health interventions. In a prior collaborative-participatory study, Agile methodology was used to co-create the web-based Pain-at-Work (PAW)... Read More about Group concept mapping to facilitate participatory design of the web-based Pain-at-Work Toolkit.

Delivering web-based workforce training interventions: the WWHIDE framework and key considerations for health research (2024)
Presentation / Conference Contribution
Blake, H., Chaplin, W., Hassard, J., & Thomson, L. (2024). Delivering web-based workforce training interventions: the WWHIDE framework and key considerations for health research. In INTED2024 Proceedings: 18th International Technology, Education and Development Conference Valencia, Spain. 4-6 March, 2024. https://doi.org/10.21125/inted.2024.1529

The workplace is an important setting for raising awareness of public health issues and delivering interventions to promote health and wellbeing of working-age adults. The role of employers in supporting the physical and mental health of their employ... Read More about Delivering web-based workforce training interventions: the WWHIDE framework and key considerations for health research.