Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST

MacDonald, Alexander Stuart; McConnachie, Alex; Dickie, David Alexander; Bath, Phillip M; Forbes, Kirsten; Quinn, Terence; Broomfield, Niall M; Dani, Krishna; Doney, Alex; Muir, Keith W; Struthers, Allan; Walters, Matthew; Barber, Mark; Bhalla, Ajay; Cameron, Alan; Guyler, Paul; Hassan, Ahamad; Kearney, Mark; Keegan, Breffni; Lakshmanan, Sekaran; Macleod, Mary Joan; Randall, Marc; Shaw, Louise; Subramanian, Ganesh; Werring, David; Dawson, Jesse

Abstract

Blood Pressure Variability (BPV) is associated with cardiovascular risk and serum uric acid level. We investigated whether BPV was lowered by allopurinol and whether it was related to neuroimaging markers of cerebral small vessel disease (CSVD) and cognition. We used data from a randomised, double-blind, placebo-controlled trial of two years allopurinol treatment after recent ischemic stroke or transient ischemic attack. Visit-to-visit BPV was assessed using brachial blood pressure (BP) recordings. Short-term BPV was assessed using ambulatory BP monitoring (ABPM) performed at 4 weeks and 2 years. Brain MRI was performed at baseline and 2 years. BPV measures were compared between the allopurinol and placebo groups, and with CSVD and cognition. 409 participants (205 allopurinol; 204 placebo) were included in the visit-to-visit BPV analyses. There were no significant differences found between placebo and allopurinol groups for any measure of visit-to-visit BPV. 196 participants were included in analyses of short-term BPV at week 4. Two measures were reduced by allopurinol: the standard deviation (SD) of systolic BP (by 1.30 mmHg (95% confidence interval (CI) 0.18–2.42, p = 0.023)); and the average real variability (ARV) of systolic BP (by 1.31 mmHg (95% CI 0.31–2.32, p = 0.011)). There were no differences in other measures at week 4 or in any measure at 2 years, and BPV was not associated with CSVD or cognition. Allopurinol treatment did not affect visit-to-visit BPV in people with recent ischemic stroke or TIA. Two BPV measures were reduced at week 4 by allopurinol but not at 2 years.

Citation

MacDonald, A. S., McConnachie, A., Dickie, D. A., Bath, P. M., Forbes, K., Quinn, T., Broomfield, N. M., Dani, K., Doney, A., Muir, K. W., Struthers, A., Walters, M., Barber, M., Bhalla, A., Cameron, A., Guyler, P., Hassan, A., Kearney, M., Keegan, B., Lakshmanan, S., …Dawson, J. (2024). Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST. Journal of Human Hypertension, 38, 307-313. https://doi.org/10.1038/s41371-024-00906-5

• Journal Article Type: Article
• Acceptance Date: Feb 22, 2024
• Online Publication Date: Mar 4, 2024
• Publication Date: 2024-04
• Deposit Date: Feb 19, 2024
• Publicly Available Date: Feb 19, 2024
• Journal: Journal of Human Hypertension
• Print ISSN: 0950-9240
• Electronic ISSN: 1476-5527
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 38
• Pages: 307-313
• DOI: https://doi.org/10.1038/s41371-024-00906-5
• Public URL: https://nottingham-repository.worktribe.com/output/22726886
• Publisher URL: https://www.nature.com/articles/s41371-024-00906-5