All Outputs (147)

Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke (2023)
Journal Article

BACKGROUND: Dual antiplatelet treatment has been shown to lower the risk of recurrent stroke as compared with aspirin alone when treatment is initiated early (≤24 hours) after an acute mild stroke. The effect of clopidogrel plus aspirin as compared w... Read More about Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke.

Denoising Diffusion MRI: Considerations and implications for analysis (2023)
Journal Article

Development of diffusion MRI (dMRI) denoising approaches has experienced considerable growth over the last years. As noise can inherently reduce accuracy and precision in measurements, its effects have been well characterised both in terms of uncerta... Read More about Denoising Diffusion MRI: Considerations and implications for analysis.

"Far Away from Home": Adolescent inpatient admissions far from home, out- of-area or to adult wards: A national surveillance study.) in collaboration with the CAPSS Scientific Committee (2023)
Journal Article

Background: The increasing prevalence and acuity of mental disorders among children and adolescents have placed pressure on services, including inpatient care, and resulted in young people being admitted at-distance or to adult wards. Little empirica... Read More about "Far Away from Home": Adolescent inpatient admissions far from home, out- of-area or to adult wards: A national surveillance study.) in collaboration with the CAPSS Scientific Committee.

Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke (2023)
Journal Article

Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may determine the extent of post-stroke vascular repair. Given the prevalence of stroke in elderly, this study explored wh... Read More about Analysis of Endothelial Progenitor Cell Subtypes as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke.

Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke (2023)
Journal Article

Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may determine the extent of post-stroke vascular repair. Given the prevalence of stroke in elderly, this study explored wh... Read More about Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke.

Pet ownership and grief - Exploring how pet ownership effects owners' mental wellbeing during times of grief, a qualitative pilot study (2023)
Journal Article

Animal-assisted interventions (AAIs) have exhibited encouraging outcomes in enhancing human mental health. However, research has investigated the potential benefits of untrained pets for human mental wellbeing, as training animals for AAI can be cost... Read More about Pet ownership and grief - Exploring how pet ownership effects owners' mental wellbeing during times of grief, a qualitative pilot study.

Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process (2023)
Journal Article

Background Care Home residents live with frailty and multiple long-term conditions. Their medical management is complex and specialised. We set out to develop a list of core competencies for doctors providing medical care in long-term care homes. M... Read More about Developing a list of core competencies for medical aspects of healthcare delivery in care homes: scoping review and Delphi process.

Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment (2023)
Journal Article

Background Infections and fever after stroke are associated with poor functional outcome or death. We assessed whether prophylactic treatment with anti-emetic, antibiotic, or antipyretic medication would improve functional outcome in older patient... Read More about Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment.

Challenges and Experiences in Multicenter Prehospital Stroke Research: Narrative Data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke Trial-2 (RIGHT-2) (2023)
Journal Article

Background: Ambulance services are increasingly research active and the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) is the largest United Kingdom (UK) ambulance-based randomized controlled trial in stroke. We... Read More about Challenges and Experiences in Multicenter Prehospital Stroke Research: Narrative Data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke Trial-2 (RIGHT-2).

Evaluating artificial intelligence software for delineating hemorrhage extent on CT brain imaging in stroke: AI delineation of ICH on CT. (2023)
Journal Article

Background: : The extent and distribution of intracranial hemorrhage (ICH) directly affects clinical management. Artificial intelligence (AI) software can detect and may delineate ICH extent on brain CT. We evaluated e-ASPECTS software (Brainomix Ltd... Read More about Evaluating artificial intelligence software for delineating hemorrhage extent on CT brain imaging in stroke: AI delineation of ICH on CT..

Neural Plasticity in Tinnitus Mechanisms (2023)
Journal Article

Investigating the feasibility, acceptability, and appropriation of a socially assistive robot among minority youth at-risk of self-harm: Results of 2 Mixed Methods Pilot Studies (2023)
Journal Article

Background: Minority youth are at an increased risk of experiencing self-harmful thoughts and behaviors. However, there is limited evidence of successful interventions to support young people in the moment of their distress. Digital interventions are... Read More about Investigating the feasibility, acceptability, and appropriation of a socially assistive robot among minority youth at-risk of self-harm: Results of 2 Mixed Methods Pilot Studies.

Supporting early‐career dementia researchers: Identifying support needs and ways forward via a European study (2023)
Journal Article

INTRODUCTION Early-career researchers contribute significantly to dementia research and clinical practice. However, a growing group of early-career dementia researchers (ECDRs) lack appropriate support throughout their careers. Thus, we aim to (i) e... Read More about Supporting early‐career dementia researchers: Identifying support needs and ways forward via a European study.

A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches (2023)
Journal Article

Despite the huge potential of magnetic resonance imaging (MRI) in mapping and exploring the brain, MRI measures can often be limited in their consistency, reproducibility and accuracy which subsequently restricts their quantifiability. Nuisance nonbi... Read More about A resource for development and comparison of multimodal brain 3T MRI harmonisation approaches.

BASIL: A Toolbox for Perfusion Quantification using Arterial Spin Labelling (2023)
Journal Article

Arterial Spin Labelling (ASL) MRI is now an established non-invasive method to quantify cerebral blood flow and is increasingly being used in a variety of neuroimaging applications. With standard ASL acquisition protocols widely available, there is a... Read More about BASIL: A Toolbox for Perfusion Quantification using Arterial Spin Labelling.

Relationship between self-reported listening and communication difficulties and executive function: a protocol for a systematic review and meta-analysis (2023)
Journal Article

Introduction: Listening and communication difficulties can limit people’s participation in activity and adversely affect their quality of life. Hearing, as well as listening and communication difficulties, can be measured either by using behavioural... Read More about Relationship between self-reported listening and communication difficulties and executive function: a protocol for a systematic review and meta-analysis.

An umbrella review of adverse effects associated with antipsychotic medications: the need for complementary study designs (2023)
Journal Article

Antipsychotic medications are widely prescribed in psychotic illnesses and other mental disorders. Effectiveness is well-established, particularly for reducing symptoms such as delusions and hallucinations, but can be impacted by tolerability. Advers... Read More about An umbrella review of adverse effects associated with antipsychotic medications: the need for complementary study designs.

Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data (2023)
Journal Article

Background There is an increasing demand for mental health services for young people, which may vary across the year. Objective To determine whether there are seasonal patterns in primary care antidepressant prescribing and mental health issues in... Read More about Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data.

Use of healthcare services before diagnosis of attention-deficit/hyperactivity disorder: a population-based matched case-control study (2023)
Journal Article

Objective: To compare use of healthcare services and reasons for attendance by children and young people (CYP) with attention-deficit/hyperactivity disorder (ADHD) versus non-ADHD controls. Design: Population-based matched case-control study. Setting... Read More about Use of healthcare services before diagnosis of attention-deficit/hyperactivity disorder: a population-based matched case-control study.

A comparative study of GNN and MLP based machine learning for the diagnosis of Alzheimer's Disease involving data synthesis. (2023)
Journal Article

Alzheimer’s Disease (AD) is a neurodegenerative disease that commonly occurs in older people. It is characterized by both cognitive and functional impairment. However, as AD has an unclear pathological cause, it can be hard to diagnose with confidenc... Read More about A comparative study of GNN and MLP based machine learning for the diagnosis of Alzheimer's Disease involving data synthesis..