All Outputs (582)

IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma (2019)
Presentation / Conference Contribution
Budd, W., Mukherjee, A., Lobo, D., & Zaitoun, A. (2019). IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma. In Supplement: Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 2–4 July 2019 (S1-S59). https://doi.org/10.1002/path.5345

Purpose of the study: IgG4, a member of the immunoglobulin family, has been implicated in the pathobiology of inflammatory disease (including autoimmune pancreatitis) and cancers. Its role in pancreatic cancers however remains to be elucidated. This... Read More about IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma.

Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact (2019)
Journal Article
Herrod, P., Adimah, A., Boyd-Carson, H., Daliya, P., El-Sharkawy, A., Sarmah, P., …Lobo, D. (2019). Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact. BMJ Open, 9, Article e028753. https://doi.org/10.1136/bmjopen-2018-028753

Objectives: To quantify the economic and psychological impact of the cancellation of operations due to winter pressures on patients, their families and the economy. Design: This questionnaire study was designed with the help of patient groups. Dat... Read More about Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact.

Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact (2019)
Journal Article
Herrod, P. J. J., Adiamah, A., Boyd-Carson, H., Daliya, P., El-Sharkawy, A. M., Sarmah, P. B., …Lobo, D. N. (2019). Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact. BMJ Open, 9(9), 1-8. https://doi.org/10.1136/bmjopen-2018-028753

Objectives To quantify the economic and psychological impact of the cancellation of operations due to winter pressures on patients, their families and the economy. Design This questionnaire study was designed with the help of patient groups. Data... Read More about Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact.

Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection (2019)
Journal Article
Monaghan, T. M., Pučić-Baković, M., Vučković, F., Lee, C., Kao, D., & Human Glycome Project. (2020). Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection. Gastroenterology, 157(6), 1676-1678.e3. https://doi.org/10.1053/j.gastro.2019.08.034

Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2019)
Journal Article
Chowdhury, A., Adiamah, A., Kushairi, A., Varadhan, K. K., Krznaric, Z., Kulkarni, A. D., …Lobo, D. N. (2020). Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Annals of Surgery, 271(6), 1036-1047. https://doi.org/10.1097/sla.0000000000003581

This meta-analysis of 34 randomized controlled trials reporting on 2723 participants has shown that perioperative administration of either probiotics or synbiotics was well tolerated and significantly reduced the risk of infectious complications foll... Read More about Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Obesity is the most common risk factor for chronic liver disease: Results from risk stratification pathway using transient elastography (2019)
Journal Article
Harris, R., Card, T. R., Delahooke, T., Aithal, G. P., & Guha, I. N. (2019). Obesity is the most common risk factor for chronic liver disease: Results from risk stratification pathway using transient elastography. American Journal of Gastroenterology, 114(11), 1744-1752. https://doi.org/10.14309/ajg.0000000000000357

Introduction Obesity has been associated with liver fibrosis yet guidelines do not emphasise it as an independent risk factor in which to have a high index of suspicion of advanced disease. We aimed to elucidate the effect of a raised body mass inde... Read More about Obesity is the most common risk factor for chronic liver disease: Results from risk stratification pathway using transient elastography.

Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis (2019)
Journal Article
Sebastian, S., Myers, S., Argyriou, K., Martin, G., Los, L., Fiske, J., …Raine, T. (2019). Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis. Alimentary Pharmacology and Therapeutics, 50(6), 675-683. https://doi.org/10.1111/apt.15456

Background: Accelerated induction regimens of infliximab have been proposed to improve response rates in patients with steroid refractory acute severe colitis. Aims: We aimed to determine differences in outcome for acute severe ulcerative colit... Read More about Infliximab induction regimens in steroid refractory acute severe colitis: a multi-centre retrospective cohort study with propensity score analysis.

Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia (2019)
Journal Article
Serra-Burriel, M., Graupera, I., Torán, P., Thiele, M., Roulot, D., Wai-Sun Wong, V., …Lammert, F. (2019). Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia. Journal of Hepatology, 71(6), 1141-1151. https://doi.org/10.1016/j.jhep.2019.08.019

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) pose an important challenge to current clinical healthcare pathways due to a large number of at-risk patients. Therefore, we aimed to explore the cost-effec... Read More about Transient elastography for screening of liver fibrosis: cost-effectiveness analysis from six prospective cohorts in Europe and Asia.

Practice pattern variability in the management of acute severe colitis: A UK provider survey (2019)
Journal Article
Sebastian, S., Lisle, J., Subramanian, S., Dhar, A., Shenoy, A., Limdi, J., …Kennedy, N. A. (2019). Practice pattern variability in the management of acute severe colitis: A UK provider survey. Frontline Gastroenterology, https://doi.org/10.1136/flgastro-2019-101277

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Introduction: Lack of comparative trial data on dosing regimens of infliximab in patients with acute severe ulcerative colitis (ASUC) failing... Read More about Practice pattern variability in the management of acute severe colitis: A UK provider survey.

Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla (2019)
Preprint / Working Paper
Al-hadyan, K., Storr, S., Zaitoun, A., Lobo, D., & Martin, S. Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla

Background: Pancreatic cancer (PC), including the ampulla and bile duct, is very aggressive, and thus difficult to treat with effective therapies. The current treatment options have failed to improve PC five-year survival rates over the last 30 to 40... Read More about Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla.

Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans (2019)
Journal Article
Alyami, J., Whitehouse, E., Yakubov, G. E., Pritchard, S. E., Hoad, C. L., Blackshaw, E., …Marciani, L. (2019). Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans. British Journal of Nutrition, https://doi.org/10.1017/S0007114519001880

Whole grain cereal breakfast consumption has been associated with beneficial effects on glucose and insulin metabolism as well as satiety. Pearl millet is a popular ancient grain variety that can be grown in hot, dry regions. However, little is known... Read More about Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans.

How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery) (2019)
Journal Article
Pauwels, A., Boecxstaens, V., Andrews, C., Attwood, S. E., Berrisford, R., Bisschops, R., …Tack, J. F. (2019). How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery). Gut, 68(11), 1928-1941. https://doi.org/10.1136/gutjnl-2019-318260

Objective: Anti-reflux surgery can be proposed in patients with gastro-esophageal reflux disease, especially when proton pump inhibitor use leads to incomplete symptom improvement. However, to date, international consensus guidelines on the clinical... Read More about How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery).

Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron (2019)
Journal Article
Gunn, D., Garsed, K., Lam, C., Singh, G., Lingaya, M., Wahl, V., …Spiller, R. (2019). Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron. Alimentary Pharmacology and Therapeutics, 50(5), 538-546. https://doi.org/10.1111/apt.15420

Background Irritable bowel syndrome with diarrhoea (IBS‐D) is a common condition, greatly reducing the quality of life with few effective treatment options available. Aims To report the beneficial response shown in our trial with the 5‐hydroyxtr... Read More about Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron.

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques (2019)
Journal Article
Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P., …Tack, J. (2019). First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nature Reviews Gastroenterology and Hepatology, 16(9), 559-579. https://doi.org/10.1038/s41575-019-0167-1

Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminol... Read More about First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.

Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery (2019)
Journal Article
Rollins, K., Mathias, N., & Lobo, D. (2019). Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery. BJS Open, 3(5), 606-616. https://doi.org/10.1002/bjs5.50188

Background: Intraoperative goal-directed fluid therapy (GDFT) is recommended for intraoperative fluid management for elective colorectal surgery in most perioperative guidelines. However, the evidence in elective colorectal surgery alone is not welle... Read More about Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery.

Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study (2019)
Journal Article
West, J., Otete, H., Sultan, A. A., & Crooks, C. J. (2019). Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study. Epidemiology, 30(4), e23-e24. https://doi.org/10.1097/EDE.0000000000001006

The diagnosis rates of coeliac disease differ substantially between countries. Intriguingly, there has been recent evidence from Olmstead County, USA and Finland that in the last 5-10 years incidence has plateaued or even declined. In most population... Read More about Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study.

A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy (2019)
Journal Article
Daliya, P., Gemmill, E. H., Lobo, D. N., & Parsons, S. L. (2019). A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy. Hepatobiliary Surgery and Nutrition, 8(3), 228-245. https://doi.org/10.21037/hbsn.2019.03.16

Background Patient Reported Outcome Measures (PROMs) provide a valuable means of measuring outcomes subjectively from a patient's perspective, facilitating the assessment of service quality across healthcare providers, and assisting patients and clin... Read More about A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy.

Development and implementation of a commissioned pathway for the identification and stratification of liver disease in the community (2019)
Journal Article
Chalmers, J., Wilkes, E., Harris, R., Kent, L., Kinra, S., Aithal, G., …Guha, I. N. (2020). Development and implementation of a commissioned pathway for the identification and stratification of liver disease in the community. Frontline Gastroenterology, 11(2), 86-92. https://doi.org/10.1136/flgastro-2019-101177

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Objective: To describe the development of the Nottingham liver disease stratification pathway, present a 12-month evaluation of uptake and stratification results... Read More about Development and implementation of a commissioned pathway for the identification and stratification of liver disease in the community.

Caffeine exposure induces browning features in adipose tissue in vitro and in vivo (2019)
Journal Article
Velickovic, K., Wayne, D., Lugo Leija, H. A., Bloor, I., Morris, D. E., Law, J., …Sottile, V. (2019). Caffeine exposure induces browning features in adipose tissue in vitro and in vivo. Scientific Reports, 9(1), Article 9104. https://doi.org/10.1038/s41598-019-45540-1

Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1). Diet can modulate UCP1 function but the capacity of individual nut... Read More about Caffeine exposure induces browning features in adipose tissue in vitro and in vivo.

Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging (2019)
Journal Article
Lam, C., Sanders, D., Lanyon, P., Garsed, K., Foley, S., Pritchard, S., …Spiller, R. (2019). Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging. United European Gastroenterology Journal, 7(10), 1353-1360. https://doi.org/10.1177/2050640619860372

Background and aims: The regular overnight migrating motor complex (MMC) ensures that the normal fasting small bowel water content (SBWC) is minimised. We have applied our recently validated non-invasive magnetic resonance technique to assess SBWC... Read More about Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging.