Skip to main content

Research Repository

Advanced Search

Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging

Lam, Ching; Sanders, David; Lanyon, Peter; Garsed, Klara; Foley, Stephen; Pritchard, Susan; Marciani, Luca; Hoad, Caroline L.; Costigan, Carolyn; Gowland, Penny; Spiller, Robin

Authors

Ching Lam

David Sanders

Peter Lanyon

Klara Garsed

Stephen Foley

Susan Pritchard

Profile Image

LUCA MARCIANI LUCA.MARCIANI@NOTTINGHAM.AC.UK
Professor of Gastrointestinal Imaging

CAROLINE HOAD CAROLINE.L.HOAD@NOTTINGHAM.AC.UK
Senior Research Fellow

Carolyn Costigan

Profile Image

ROBIN SPILLER ROBIN.SPILLER@NOTTINGHAM.AC.UK
Professor of Gastroenterology



Abstract

Background and aims: The regular overnight migrating motor complex (MMC) ensures that the normal fasting small bowel water content (SBWC) is minimised. We have applied our recently validated non-invasive magnetic resonance technique to assess SBWC in newly diagnosed coeliac disease (CD), scleroderma (SCD) and irritable bowel syndrome (IBS) conditions, possibly associated with small intestinal bacterial overgrowth (SIBO).

Methods: 20 CD and 15 SCD patients with gastrointestinal symptoms were compared to 20 healthy volunteers (HV) and 26 IBS with diarrhoea (IBS-D) patients as previously reported. All underwent a fasting, magnetic resonance imaging (MRI) scan on a 1.5 T Philips Achieva MRI scanner to assess fasting SBWC and colonic volumes. Stool and symptom diaries were completed for 1 week.

Results: Median (Interquartile range, IQR)
Compared to healthy volunteers, all the patients had significantly increased stool frequency and Bristol stool form score. SBWC was significantly increased in CD 109(53-224) vs. 53(31-98) mL in HV, p [less than] 0.01 and 42 (28-67) in IBS-D, p [less than] 0.01. Variable increase in SBWC was also found in SCD, median 77(39-158) but this was not significant, p=0.2. Colonic volumes were similar for all groups being 547 (442-786) for CD, 511 (453-789) for SCD, 612 (445-746) for HV and 521 (428-757) mL for IBS-D. When CD patients were subdivided according to the Marsh classification, the higher grades had larger colonic volumes.

Conclusion: Fasting SBWC as assessed by MRI is significantly increased in newly diagnosed CD and SCD but decreased in IBS-D. Future studies should test whether increased resting fluid predisposes to SIBO.

Citation

Lam, C., Sanders, D., Lanyon, P., Garsed, K., Foley, S., Pritchard, S., …Spiller, R. (2019). Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging. United European Gastroenterology Journal, 7(10), 1353-1360. https://doi.org/10.1177/2050640619860372

Journal Article Type Article
Acceptance Date May 28, 2019
Online Publication Date Jun 21, 2019
Publication Date Dec 1, 2019
Deposit Date Jun 14, 2019
Publicly Available Date Mar 28, 2024
Journal United European Gastroenterology Journal
Print ISSN 2050-6406
Electronic ISSN 2050-6414
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 7
Issue 10
Pages 1353-1360
DOI https://doi.org/10.1177/2050640619860372
Keywords Small bowel; Magnetic resonance imaging; Irritable bowel syndrome; Coeliac disease; Scleroderma
Public URL https://nottingham-repository.worktribe.com/output/2188020
Publisher URL https://journals.sagepub.com/doi/full/10.1177/2050640619860372
Additional Information Lam, C., Sanders, D. S., Lanyon, P., Garsed, K., Foley, S., Pritchard, S., … Spiller, R. (2019). Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging. United European Gastroenterology Journal. https://doi.org/10.1177/2050640619860372