All Outputs (5)

A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes. (2023)
Journal Article
Ng, C., Dellschaft, N. S., Hoad, C., Marciani, L., Spiller, R., Crooks, C., …Smyth, A. R. (2023). A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes. NIHR Open Research, 3(65), 1-16. https://doi.org/10.3310/nihropenres.13510.1

Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung fun... Read More about A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes..

Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies (2021)
Journal Article
Dellschaft, N., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2022). Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies. Alimentary Pharmacology and Therapeutics, 55(3), 327-338. https://doi.org/10.1111/apt.16673

Background: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). Aims: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide dat... Read More about Small bowel water content assessed by MRI in health and disease: a collation of single-centre studies.

Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers (2019)
Journal Article
Wilkinson-Smith, V., Dellschaft, N., Ansell, J., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2019). Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers. Alimentary Pharmacology and Therapeutics, 49(6), 759-768. https://doi.org/10.1111/apt.15127

Background: Chronic constipation affects approximately 17% of the population worldwide and remains an important unmet need since patients are often dissatisfied with treatment. Kiwifruit may offer an alternative to traditional laxatives and have been... Read More about Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers.

Tissue cell stress response to obesity and its interaction with late gestational diet (2017)
Journal Article
Saroha, V., Dellschaft, N. S., Keisler, D. H., Gardner, D. S., Budge, H., Sebert, S. P., & Symonds, M. E. (2018). Tissue cell stress response to obesity and its interaction with late gestational diet. Reproduction, Fertility and Development, 30, https://doi.org/10.1071/RD16494

Intra-uterine growth restriction in late pregnancy can contribute to adverse long term metabolic health in the offspring. We utilised an animal (sheep) model of maternal dietary manipulation in late pregnancy, combined with exposure of the offspring... Read More about Tissue cell stress response to obesity and its interaction with late gestational diet.

Beyond obesity - thermogenic adipocytes and cardiometabolic health (2017)
Journal Article
Aldiss, P., Dellschaft, N. S., Sacks, H., Budge, H., & Symonds, M. E. (in press). Beyond obesity - thermogenic adipocytes and cardiometabolic health. Hormone Molecular Biology and Clinical Investigation, 31(2), https://doi.org/10.1515/hmbci-2017-0007

The global prevalence of obesity and related cardiometabolic disease continues to increase through the 21st century. Whilst multi-factorial, obesity is ultimately caused by chronic caloric excess. However, despite numerous interventions focussing on... Read More about Beyond obesity - thermogenic adipocytes and cardiometabolic health.