All Outputs (21)

Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry (2014)
Journal Article

Background Barrett's oesophagus (BE) is a pre-malignant condition leading to oesophageal adenocarcinoma (OAC). Treatment of neoplasia at an early stage is desirable. Combined endoscopic mucosal resection (EMR) followed by radiofrequency ablation (RFA... Read More about Improvement over time in outcomes for patients undergoing endoscopic therapy for Barrett's oesophagus-related neoplasia: 6-year experience from the first 500 patients treated in the UK patient registry.

Preoperative carbohydrate supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression (2014)
Journal Article

Human leukocyte antigen genetic risk factors of drug-induced liver toxicology (2014)
Journal Article

Introduction: Drug-induced liver injury (DILI) is a rare adverse drug reaction, which impacts significantly on patients. Human leukocyte antigen (HLA) risk alleles have been found to be associated with DILI supporting an immunological basis to DILI p... Read More about Human leukocyte antigen genetic risk factors of drug-induced liver toxicology.

Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus (2014)
Journal Article

Toll-like receptor expression in crypt epithelial cells, putative stem cells and intestinal myofibroblasts isolated from controls and patients with inflammatory bowel disease (2014)
Journal Article

Magnetic resonance spectroscopy measurements of intragastric fat fraction of oil emulsions in humans (2014)
Journal Article

Functional recovery is considered the most important target: a survey of dedicated professionals (2014)
Journal Article

Background: The aim of this study was to survey the relative importance of postoperative recovery targets and perioperative care items, as perceived by a large group of international dedicated professionals. Methods: A questionnaire with eight posto... Read More about Functional recovery is considered the most important target: a survey of dedicated professionals.

Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of splitvssingle dose (2014)
Journal Article

Gut reactions (2014)
Journal Article

Effect of a Perioperative, Cardiac Output–Guided Hemodynamic Therapy Algorithm on Outcomes Following Major Gastrointestinal Surgery: A Randomized Clinical Trial and Systematic Review (2014)
Journal Article

A Randomized, Controlled, Double-Blind Crossover Study on the Effects of 1-L Infusions of 6% Hydroxyethyl Starch Suspended in 0.9% Saline (Voluven) and a Balanced Solution (Plasma Volume Redibag) on Blood Volume, Renal Blood Flow Velocity, and Renal Cortical Tissue Perfusion in Healthy Volunteers (2014)
Journal Article

Objective: We compared the effects of intravenous administration of 6% hydroxyethyl starch (maize-derived) in 0.9% saline (Voluven; Fresenius Kabi, Runcorn, United Kingdom) and a “balanced” preparation of 6% hydroxyethyl starch (potato-derived) [Plas... Read More about A Randomized, Controlled, Double-Blind Crossover Study on the Effects of 1-L Infusions of 6% Hydroxyethyl Starch Suspended in 0.9% Saline (Voluven) and a Balanced Solution (Plasma Volume Redibag) on Blood Volume, Renal Blood Flow Velocity, and Renal Cortical Tissue Perfusion in Healthy Volunteers.

Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus (2014)
Journal Article

RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands. Its ability to remodel replication forks and to genetically interact wi... Read More about Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus.

Phenotypic Features of Crohn's Disease Associated With Failure of Medical Treatment (2014)
Journal Article

Radiofrequency Ablation vs Endoscopic Surveillance for Patients With Barrett Esophagus and Low-Grade Dysplasia: A Randomized Clinical Trial (2014)
Journal Article

Importance Barrett esophagus containing low-grade dysplasia is associated with an increased risk of developing esophageal adenocarcinoma, a cancer with a rapidly increasing incidence in the western world. Objective To investigate whether end... Read More about Radiofrequency Ablation vs Endoscopic Surveillance for Patients With Barrett Esophagus and Low-Grade Dysplasia: A Randomized Clinical Trial.

A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach (2014)
Journal Article

Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gastric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and... Read More about A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach.

Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease (2014)
Journal Article

Non-alcohol-related fatty liver disease (NAFLD) encompasses a wide spectrum, ranging from steatosis alone to steatohepatitis and fibrosis. Presence of steatohepatitis and fibrosis are key hallmarks of disease progression. Previous studies have demons... Read More about Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease.

Venous thromboembolism in children with cancer – a population-based cohort study (2014)
Journal Article

Introduction: Cancer is a known risk factor for venous thromboembolism (VTE) in adults, but population-based data in children are scarce. Materials and methods: We conducted a cohort study utilising linkage of the Clinical Practice Research Datab... Read More about Venous thromboembolism in children with cancer – a population-based cohort study.

Novel concepts in inflammatory bowel disease (2014)
Journal Article

CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa (2014)
Journal Article

Background Helicobacter pylori-induced peptic ulceration is less likely to occur in patients with a strong gastric anti-inflammatory regulatory T cell (Treg) response. Migration of Tregs into the gastric mucosa is therefore important. Objective To... Read More about CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa.

Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells (2014)
Journal Article

Persistent Helicobacter pylori infection induces chronic inflammation in the human gastric mucosa, which is associated with development of peptic ulceration, gastric atrophy, and gastric adenocarcinoma. It has been postulated that secretion of immuno... Read More about Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells.