Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplat... Read More about Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.
All Outputs (64)
4th symposium on primary breast cancer in older women. Theme: putting personalized care into practice (held: 3 March 2017) (2017)
Journal Article
Following the inception in 2010, the University of Nottingham hosted the 4th Symposium on Primary Breast Cancer in Older Women, under the auspices of the International Society of Geriatric Oncology, in March 2017, at East Midlands Conference Centre.... Read More about 4th symposium on primary breast cancer in older women. Theme: putting personalized care into practice (held: 3 March 2017).
Feed thickener for infants up to six months of age with gastro-oesophageal reflux (Review) (2017)
Journal Article
Background Gastro-oesophageal reflux (GOR) is common in infants, and feed thickeners are often used to manage it in infants as they are simple to use and perceived to be harmless. However, conflicting evidence exists to support the use of feed thick... Read More about Feed thickener for infants up to six months of age with gastro-oesophageal reflux (Review).
A continuing mission to optimize the care of older women with breast cancer (2017)
Journal Article
The majority of cases of breast cancer occur in the older population who are often un-represented in clinical trials. Given the growing ageing population globally, it becomes urgent and important to identify an optimal approach so that older women wi... Read More about A continuing mission to optimize the care of older women with breast cancer.
Tumour boards in geriatric oncology (2017)
Journal Article
Multidisciplinary tumour board (MDT) is an integral part of cancer treatment planning. Although no definite survival benefits have yet been shown by mostly observational studies, other benefits of MDT have been identified. Traditionally the MDT invol... Read More about Tumour boards in geriatric oncology.
OA 06.08 Is Lung Cancer Screening Associated with a Negative Psychological Impact? (2017)
Journal Article
Accessing scientific information (2017)
Journal Article
Practising evidence based medicine is recognised as essential to ensure that patients receive the best possible treatment. For health professionals to be able to practice evidence based medicine, they need to be able to access scientific information.... Read More about Accessing scientific information.
Optimal NHS service delivery to care homes: a realist evaluation of the features and mechanisms that support effective working for the continuing care of older people in residential settings (2017)
Journal Article
Background: Care homes are the institutional providers of long-term care for older people. The OPTIMAL study argued that it is probable that there are key activities within different models of health-care provision that are important for residents’ h... Read More about Optimal NHS service delivery to care homes: a realist evaluation of the features and mechanisms that support effective working for the continuing care of older people in residential settings.
Indentifying published studies of care home research: an international survey of researchers (2017)
Journal Article
Collating the published research around institutional, long term care is confounded by the differing terminologies used to describe this health-care setting. We aimed to collate the descriptors used by researchers to inform the future development of... Read More about Indentifying published studies of care home research: an international survey of researchers.
Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men (2017)
Journal Article
Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the e... Read More about Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.
Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon (2017)
Journal Article
Objective: We sought to quantify the anti-inflammatory effects of two cannabinoid drugs, cannabidiol (CBD) and palmitoylethanolamide (PEA), in cultured cell lines and compared this effect with experimentally inflamed explant human colonic tissue. The... Read More about Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon.
The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study (2017)
Journal Article
© 2017 Shardlow et al. Background: To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK and international guidelines recommend that cystatin-C-bas... Read More about The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study.
Introduction Care home residents are relatively high users of healthcare resources and may have complex needs. Comprehensive geriatric assessment (CGA) may benefit care home residents and improve efficiency of care delivery. This is an approach t... Read More about Using comprehensive geriatric assessment for quality improvements in healthcare of older people in UK care homes: protocol for realist review within Proactive Healthcare of Older People in Care Homes (PEACH) study.
Medication errors in infants at home (2017)
Journal Article
The study by Solanki and colleagues involved interviewing 166 parents/grandparents at home regarding the medications that had been prescribed at discharge to their infants, by the hospital staff [1]. As part of the study, the parents were also asked... Read More about Medication errors in infants at home.
Effects of obesity on metabolic and cardiovascular outcomes following insulin initiation in patients with type 2 diabetes (2017)
Journal Article
Objectives Insulin therapy induces weight gain but whether it causes long term adverse metabolic and CV outcomes in obese patients remains unclear. Methods A retrospective cohort study of 12,725 insulin initiators with T2D derived from UK Genera... Read More about Effects of obesity on metabolic and cardiovascular outcomes following insulin initiation in patients with type 2 diabetes.
Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease (2017)
Journal Article
Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2*), and microstructure (diffusion, T1 mapping)... Read More about Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease.
A 4-week, lifestyle-integrated, home-based exercise training programme elicits improvements in physical function and lean mass in older men and women: a pilot study (2017)
Journal Article
Background: Developing alternative exercise programmes that can alleviate certain barriers to exercise such as psychological, environmental or socio-economical barriers, but provide similar physiological benefits e.g. increases in muscle mass and str... Read More about A 4-week, lifestyle-integrated, home-based exercise training programme elicits improvements in physical function and lean mass in older men and women: a pilot study.
A practical and time-efficient high-intensity interval training program modifies cardio-metabolic risk factors in adults with risk factors for type ii diabetes (2017)
Journal Article
Introduction: Regular physical activity (PA) can reduce the risk of developing type 2 diabetes, but adherence to time-orientated (150 min week−1 or more) PA guidelines is very poor. A practical and time-efficient PA regime that was equally efficaciou... Read More about A practical and time-efficient high-intensity interval training program modifies cardio-metabolic risk factors in adults with risk factors for type ii diabetes.