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Effective health care for older people living and dying in care homes: a realist review (2016)
Journal Article
Goodman, C., Dening, T., Gordon, A. L., Davies, S. L., Meyer, J., Martin, F. C., …Zubair, M. (in press). Effective health care for older people living and dying in care homes: a realist review. BMC Health Services Research, 16(269), https://doi.org/10.1186/s12913-016-1493-4

Background: Care home residents in England have variable access to health care services. There is currently no coherent policy or consensus about the best arrangements to meet these needs. The purpose of this review was to explore the evidence for ho... Read More about Effective health care for older people living and dying in care homes: a realist review.

Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition (2016)
Journal Article
Mitchell, W. K., Wilkinson, D. J., Phillips, B. E., Lund, J. N., Smith, K., & Atherton, P. J. (2016). Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition. Advances in Nutrition, 7(4), 828S-838S. doi:10.3945/an.115.011650

Healthy individuals maintain remarkably constant skeletal muscle mass across much of adult life, suggesting the existence of robust homeostatic mechanisms. Muscle exists in dynamic equilibrium whereby the influx of amino acids (AAs) and the resulting... Read More about Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition.

Adequacy of Online Patient Information Resources on Gout and Potentially Curative Urate-Lowering Treatment (2016)
Journal Article
Jimenez-Liñan, L. M., Edwards, L., Abhishek, A., & Doherty, M. (2017). Adequacy of Online Patient Information Resources on Gout and Potentially Curative Urate-Lowering Treatment. Arthritis Care and Research, 69(5), 748-752. https://doi.org/10.1002/acr.22981

© 2016, American College of Rheumatology Objective: To assess the content and readability of online patient information resources against the current understanding of gout. Methods: An online survey was undertaken using Google UK, USA, Australia, and... Read More about Adequacy of Online Patient Information Resources on Gout and Potentially Curative Urate-Lowering Treatment.

Human blood autoantibodies in the detection of colorectal cancer (2016)
Journal Article
Negm, O. H., Hamed, M. R., Schoen, R. E., Whelan, R. L., Steele, R. J., Scholefield, J., …Sewell, H. F. (2016). Human blood autoantibodies in the detection of colorectal cancer. PLoS ONE, 11(7), 1-14. https://doi.org/10.1371/journal.pone.0156971

Colorectal cancer (CRC) is the second most common malignancy in the western world. Early detection and diagnosis of all cancer types is vital to improved prognosis by enabling early treatment when tumours should be both resectable and curable. Sera f... Read More about Human blood autoantibodies in the detection of colorectal cancer.

An overview of technical considerations for Western blotting applications to physiological research (2016)
Journal Article
Bass, J. J., Wilkinson, D. J., Rankin, D., Phillips, B. E., Szewczyk, N. J., Smith, K., & Atherton, P. J. (in press). An overview of technical considerations for Western blotting applications to physiological research. Scandinavian Journal of Medicine and Science in Sports, 27(1), https://doi.org/10.1111/sms.12702

The applications of Western/immuno-blotting (WB) techniques have reached multiple layers of the scientific community and are now considered routine procedures in the field of physiology. This is none more so than in relation to skeletal muscle physio... Read More about An overview of technical considerations for Western blotting applications to physiological research.

A simple care bundle for use in acute kidney injury: a propensity score-matched cohort study (2016)
Journal Article
Kolhe, N. V., Reilly, T., Leung, J., Fluck, R. J., Swinscoe, K. E., Selby, N. M., & Taal, M. W. (2016). A simple care bundle for use in acute kidney injury: a propensity score-matched cohort study. Nephrology Dialysis Transplantation, 31(11), https://doi.org/10.1093/ndt/gfw087

Background Consensus guidelines for acute kidney injury (AKI) have recommended prompt treatment including attention to fluid balance, drug dosing and avoidance of nephrotoxins. These simple measures can be incorporated in a care bundle to facilita... Read More about A simple care bundle for use in acute kidney injury: a propensity score-matched cohort study.

Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development (2016)
Journal Article
Mora-Lorca, J. A., Sáenz-Narciso, B., Gaffney, C. J., Naranjo-Galindo, F. J., Pedrajas, J. R., Guerrero-Gómez, D., …Miranda-Vizuete, A. (in press). Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development. Free Radical Biology and Medicine, 96, https://doi.org/10.1016/j.freeradbiomed.2016.04.017

Glutathione is the most abundant thiol in the vast majority of organisms and is maintained in its reduced form by the flavoenzyme glutathione reductase. In this work, we describe the genetic and functional analysis of the Caenorhabditis elegans gsr-1... Read More about Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development.

iGEMS: an integrated model for identification of alternative exon usage events (2016)
Journal Article
Sood, S., Szkop, K. J., Nakhuda, A., Gallagher, I. J., Murie, C., Brogan, R. J., …Timmons, J. A. (2016). iGEMS: an integrated model for identification of alternative exon usage events. Nucleic Acids Research, 44(11), e109. https://doi.org/10.1093/nar/gkw263

DNA microarrays and RNAseq are complementary methods for studying RNA molecules. Current computational methods to determine alternative exon usage (AEU) using such data require impractical visual inspection and still yield high false-positive rates.... Read More about iGEMS: an integrated model for identification of alternative exon usage events.

The development and evaluation of mini-GEMs: a short, focused, online e-learning videos in geriatric medicine (2016)
Journal Article
Garside, M. J., Fisher, J. M., Blundell, A. G., & Gordon, A. L. (in press). The development and evaluation of mini-GEMs: a short, focused, online e-learning videos in geriatric medicine. Gerontology and Geriatrics Education, https://doi.org/10.1080/02701960.2016.1165217

Mini Geriatric E-Learning Modules (Mini-GEMs) are short, focused, e-learning videos on geriatric medicine topics, hosted on YouTube, which are targeted at junior doctors working with older people. This study aimed to explore how these resources are a... Read More about The development and evaluation of mini-GEMs: a short, focused, online e-learning videos in geriatric medicine.

The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review (2016)
Journal Article
Mohamed, A. A., Al-Hussaini, T. K., Fathalla, M. M., El Shamy, T. T., Abdelaal, I. I., & Amer, S. A. (2016). The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review. American Journal of Obstetrics and Gynecology, 215(2), https://doi.org/10.1016/j.ajog.2016.03.045

Background Benign nonendometriotic ovarian cysts are very common and often require surgical excision. However, there has been a growing concern over the possible damaging effect of this surgery on ovarian reserve. Objective The aim of this m... Read More about The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review.

A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia (2016)
Journal Article
Pannérec, A., Springer, M., Migliavacca, E., Ireland, A., Piasecki, M., Karaz, S., …Feige, J. N. (2016). A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia. Aging, 8(4), 712-728. https://doi.org/10.18632/aging.100926

Declining muscle mass and function is one of the main drivers of loss of independence in the elderly. Sarcopenia is associated with numerous cellular and endocrine perturbations, and it remains challenging to identify those changes that play a causal... Read More about A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia.

Sex differences in the effects of 12?weeks sprint interval training on body fat mass and the rates of fatty acid oxidation and VO2max during exercise (2016)
Journal Article
Bagley, L., Slevin, M., Bradburn, S., Liu, D., Murgatroyd, C., Morrissey, G., …McPhee, J. S. (2016). Sex differences in the effects of 12 weeks sprint interval training on body fat mass and the rates of fatty acid oxidation and VO2max during exercise. BMJ Open Sport and Exercise Medicine, 2(1), Article e000056. https://doi.org/10.1136/bmjsem-2015-000056

Anaesthetists stress is induced by patient ASA grade and may impair non-technical skills during intubation (2016)
Journal Article
Doleman, B., Blackwell, J., Karangizi, A., Butt, W., Bhalla, A., Lund, J. N., & Williams, J. P. (2016). Anaesthetists stress is induced by patient ASA grade and may impair non-technical skills during intubation. Acta Anaesthesiologica Scandinavica, 60(7), 910-916. https://doi.org/10.1111/aas.12716

Background The aims of this study were to determine if patient ASA grade was associated with increased stress in anaesthetists with a subsequent effect on non-technical skills. Methods Stress was measured using a validated objective (heart rat... Read More about Anaesthetists stress is induced by patient ASA grade and may impair non-technical skills during intubation.

New horizons in the implementation and research of comprehensive geriatric assessment: knowing, doing and the “know-do” gap (2016)
Journal Article
Gladman, J. R., Conroy, S. P., Ranhoff, A. H., & Gordon, A. L. (2016). New horizons in the implementation and research of comprehensive geriatric assessment: knowing, doing and the “know-do” gap. Age and Ageing, 45(2), 194-200. https://doi.org/10.1093/ageing/afw012

In this paper we outline the relationship between the need to put existing applied health research knowledge into practice (the “know-do gap”) and the need to improve the evidence base (the “know gap”) with respect to the health care process used for... Read More about New horizons in the implementation and research of comprehensive geriatric assessment: knowing, doing and the “know-do” gap.

Safety of Levetiracetam in paediatrics: a systematic review (2016)
Journal Article
Egunsola, O., Choonara, I., & Sammons, H. M. (2016). Safety of Levetiracetam in paediatrics: a systematic review. PLoS ONE, 11(3), Article e0149686. https://doi.org/10.1371/journal.pone.0149686

Objective To identify adverse events (AEs) associated with Levetiracetam (LEV) in children. Methods Databases EMBASE (1974-February 2015) and Medline (1946-February 2015) were searched for articles in which paediatric patients (?18 years) received... Read More about Safety of Levetiracetam in paediatrics: a systematic review.

The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts (2016)
Journal Article
Aleskandarany, M. A., Agarwal, D., Negm, O. H., Ball, G., Elmouna, A., Ashankyty, I., …Rakha, E. A. (2016). The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts. Breast Cancer Research and Treatment, 156(1), 9-20. https://doi.org/10.1007/s10549-016-3709-z

Signal transducer and activator of transcription (STAT) transcription factors family are involved in diverse cellular biological functions. Reports regarding the prognostic impact of STAT3 expression in breast cancer (BC) are variable whether being a... Read More about The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts.

Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men (2016)
Journal Article
Phillips, B. E., Atherton, P. J., Varadhan, K., Limb, M. C., Williams, J. P., & Smith, K. (in press). Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men. Applied Physiology, Nutrition, and Metabolism, 41(5), https://doi.org/10.1139/apnm-2015-0543

The anabolic effects of nutrition on skeletal muscle may depend on adequate skeletal muscle perfusion, which is impaired in older people. Cocoa flavanols have been shown to improve flow-mediated dilation, an established measure of endothelial functio... Read More about Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men.

Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome (2016)
Journal Article
Cadagan, D., Khan, R., & Amer, S. A. (2016). Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome. Reproductive Biology -Olsztyn-, 16(1), https://doi.org/10.1016/j.repbio.2015.12.006

This study examined whether a defect of steroid synthesis in ovarian theca cells may lead to the development of PCOS, through contributions to excess androgen secretion. Polycystic ovarian syndrome (PCOS) is one of the leading causes of infertilit... Read More about Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome.