Skip to main content

Research Repository

Advanced Search

All Outputs (545)

Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection (2014)
Journal Article
Elliker, K. R., Armstrong, S., Sommerville, B. A., Broom, D. M., Neal, D. E., & Williams, H. C. (2014). Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection. BMC Urology, 14(1), 1-9. https://doi.org/10.1186/1471-2490-14-22

Background: Cancer detection using sniffer dogs is a potential technology for clinical use and research. Our study sought to determine whether dogs could be trained to discriminate the odour of urine from men with prostate cancer from controls, using... Read More about Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection.

Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials. (2014)
Journal Article
Mason, J. M., Thomas, K., Crook, A. M., Foster, K. A., Chalmers, J., Nunn, A. J., & Williams, H. C. (2014). Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials. PLoS ONE, 9(2), https://doi.org/10.1371/journal.pone.0082694

Background Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. We assessed the cost-effectiveness of prophylactic antibiotic treatment to prevent the recurrence of cellulitis using low dose... Read More about Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials..

1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study (2014)
Journal Article
Ratib, S., Fleming, K. M., Crooks, C. J., Aithal, G. P., & West, J. (2014). 1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study. Journal of Hepatology, 60(2), https://doi.org/10.1016/j.jhep.2013.09.027

BACKGROUND & AIMS: Large, population-based studies that have included the full spectrum of cirrhosis estimating survival, taking into account time-at-risk are lacking. We aimed to report 1- and 5-year average survival rates for people with cirrhosis... Read More about 1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: a large population study.

Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer (2014)
Journal Article
Ratib, S., West, J., Crooks, C. J., & Fleming, K. M. (2014). Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer. American Journal of Gastroenterology, 109(2), https://doi.org/10.1038/ajg.2013.405

OBJECTIVES: There is no routine registration of the occurrence of newly diagnosed cases of cirrhosis in the United Kingdom. This study seeks to determine precise estimates and trends of the incidence of cirrhosis in England, and directly compare the... Read More about Occurrence of liver cirrhosis in England, a cohort study, 1998-2009: a comparison with cancer.

Rising burden of gout in the UK but continuing suboptimal management: A nationwide population study (2014)
Journal Article
Kuo, C. F., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2015). Rising burden of gout in the UK but continuing suboptimal management: A nationwide population study. Annals of the Rheumatic Diseases, 74(4), 661-667. https://doi.org/10.1136/annrheumdis-2013-204463

Objectives: To describe trends in the epidemiology of gout and patterns of urate-lowering treatment (ULT) in the UK general population from 1997 to 2012. Methods: We used the Clinical Practice Research Datalink to estimate the prevalence and incidenc... Read More about Rising burden of gout in the UK but continuing suboptimal management: A nationwide population study.

Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial (2013)
Journal Article
Bath-Hextall, F., Ozolins, M., Armstrong, S. J., Colver, G. B., Perkins, W., Miller, P. S., & Williams, H. C. (2014). Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial. Lancet Oncology, 15(1), 96-105. https://doi.org/10.1016/S1470-2045%2813%2970530-8

Background: Basal-cell carcinoma is the most common form of skin cancer and its incidence is increasing worldwide. We aimed to assess the effectiveness of imiquimod cream versus surgical excision in patients with low-risk basal-cell carcinoma. Method... Read More about Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial.

Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan (2013)
Journal Article
Kuo, C., Grainge, M. J., See, L., Yu, K., Luo, S., Valdes, A. M., …Doherty, M. (2015). Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the Rheumatic Diseases, 74(2), 369-374. https://doi.org/10.1136/annrheumdis-2013-204067

© 2015, BMJ Publishing Group. All rights reserved. Objective: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. Methods: Using data from the Nati... Read More about Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.

Work disability and state benefit claims in early rheumatoid arthritis: the ERAN cohort (2013)
Journal Article
McWilliams, D. F., Varughese, S., Young, A., Kiely, P. D., & Walsh, D. A. (2014). Work disability and state benefit claims in early rheumatoid arthritis: the ERAN cohort. Rheumatology, 53(3), 473-481. https://doi.org/10.1093/rheumatology/ket373

Objective. RA is an important cause of work disability. This study aimed to identify predictive factors for work disability and state benefit claims in a cohort with early RA. Methods. The Early RA Network (ERAN) inception cohort recruited from 22... Read More about Work disability and state benefit claims in early rheumatoid arthritis: the ERAN cohort.

Association between low cortical bone mineral density, soft-tissue calcification, vascular calcification and chondrocalcinosis: a case-control study (2013)
Journal Article
Doherty, S., Doherty, M., Maciewicz, R., Abhishek, A., Muir, K., & Zhang, W. (2014). Association between low cortical bone mineral density, soft-tissue calcification, vascular calcification and chondrocalcinosis: a case-control study. Annals of the Rheumatic Diseases, 73(11), 1997-2002. https://doi.org/10.1136/annrheumdis-2013-203400

Baseline factors predicting change from the initial DMARD treatment during the first 2?years of rheumatoid arthritis: experience in the ERAN inception cohort (2013)
Journal Article
McWilliams, D. F., Kiely, P. D., Young, A., & Walsh, D. A. (2013). Baseline factors predicting change from the initial DMARD treatment during the first 2?years of rheumatoid arthritis: experience in the ERAN inception cohort. BMC Musculoskeletal Disorders, 14(May), Article 7. https://doi.org/10.1186/1471-2474-14-153

Background Outcomes in early Rheumatoid Arthritis (RA) may be improved by rapidly establishing a stable and effective disease modifying anti-rheumatic drug (DMARD) treatment regimen. We aimed to investigate whether baseline factors and initial treat... Read More about Baseline factors predicting change from the initial DMARD treatment during the first 2?years of rheumatoid arthritis: experience in the ERAN inception cohort.

Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGF?1) gene in knee and hip osteoarthritis (2013)
Journal Article
Muthuri, S. G., Doherty, S., Zhang, W., Maciewicz, R. A., Muir, K. R., & Doherty, M. (2013). Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGF?1) gene in knee and hip osteoarthritis. Arthritis Research and Therapy, 15(2), Article R52. https://doi.org/10.1186/ar4214

Introduction: The objective was to investigate potential gene-environment interaction between body mass index (BMI) and each of eight TGF?1 polymorphisms in knee and hip osteoarthritis (OA). Methods: We conducted a case-control study of Caucasian me... Read More about Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGF?1) gene in knee and hip osteoarthritis.

Examining the role of oral contraceptive users as an experimental and/or control group in athletic performance studies (2012)
Journal Article
Elliott-Sale, K. J., Smith, S., Bacon, J., Clayton, D., McPhilimey, M., Goutianos, G., …Sale, C. (2013). Examining the role of oral contraceptive users as an experimental and/or control group in athletic performance studies. Contraception, 88(3), 408-412. https://doi.org/10.1016/j.contraception.2012.11.023

Background This study was conducted to examine the effect of oral contraceptives on endogenous reproductive hormone levels in order to assess the suitability of oral contraceptive users as experimental and/or control groups in human performance st... Read More about Examining the role of oral contraceptive users as an experimental and/or control group in athletic performance studies.

Quantitative sensory testing in painful osteoarthritis: A systematic review and meta-analysis (2012)
Journal Article
Suokas, A. K., Walsh, D. A., McWilliams, D. F., Condon, L., Moreton, B., Wylde, V., …Zhang, W. (2012). Quantitative sensory testing in painful osteoarthritis: A systematic review and meta-analysis. Osteoarthritis and Cartilage, 20(10), 1075-1085. https://doi.org/10.1016/j.joca.2012.06.009

Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA). Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, PubMed, Web of Science) were searche... Read More about Quantitative sensory testing in painful osteoarthritis: A systematic review and meta-analysis.

The use of the ASET in the diagnosis of ventriculoatrial shunt infection: a case report (2012)
Journal Article
Reaper, J., Collins, S. A., & Bayston, R. (2012). The use of the ASET in the diagnosis of ventriculoatrial shunt infection: a case report. BMJ Case Reports, https://doi.org/10.1136/bcr.2012.006164

A 38yr-old male with a ventriculoatrial shunt presented with nonspecific symptoms (headache, back pain, night sweats) and inconclusive laboratory results. He showed an extremely high titre of antibody to Staphylococcus epidermidis which proved diagno... Read More about The use of the ASET in the diagnosis of ventriculoatrial shunt infection: a case report.

Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro (2012)
Journal Article
Bayston, R., Ullas, G., & Ashraf, W. (2012). Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro. Antimicrobial Agents and Chemotherapy, 56(6), https://doi.org/10.1128/AAC.06326-11

Cerebrospinal fluid (CSF) shunts used to treat hydrocephalus have an overall infection rate of about 10% of operations. The commonest causative bacteria are Staphylococcus epidermidis, followed by Staphylococcus aureus and enterococci. Major difficul... Read More about Action of linezolid or vancomycin on biofilms in ventriculoperitoneal shunts in vitro.

Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study (2012)
Journal Article
McWilliams, D. F., Zhang, W., Mansell, J. S., Kiely, P. D., Young, A., & Walsh, D. A. (2012). Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study. Arthritis Care and Research, 64(10), https://doi.org/10.1002/acr.21723

Objective: To investigate possible predictors for lack of pain improvement after 1 year of treatment for early rheumatoid arthritis (RA). Methods: The Early Rheumatoid Arthritis Network (ERAN) database was used for analysis of baseline and 1-year... Read More about Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study.