All Outputs (85)

Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network (2021)
Journal Article
Ifesemen, O. S., McWilliams, D. F., Norton, S., Kiely, P. D. W., Young, A., & Walsh, D. A. (2022). Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network. Rheumatology, 61(9), 3737-3745. https://doi.org/10.1093/rheumatology/keab947

OBJECTIVES: Fatigue is a disabling symptom in people with RA. This study aims to describe the prevalence, risk factors and longitudinal course of fatigue in early RA. METHODS: Demographic, clinical, quality of life (QoL), comorbidities and laboratory... Read More about Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network.

Response to ‘The role of curettage as an intervention for basal cell carcinoma’. Re. ‘Interventions for basal cell carcinoma: abridged Cochrane systematic review and GRADE assessments’: reply from the authors (2021)
Journal Article
Bath-Hextall, F. J., Thomson, J., Hogan, S., Leonardi-Bee, J., Williams, H. C., & Bath‐Hextall, F. (2022). Response to ‘The role of curettage as an intervention for basal cell carcinoma’. Re. ‘Interventions for basal cell carcinoma: abridged Cochrane systematic review and GRADE assessments’: reply from the authors. British Journal of Dermatology, 186(4), 751-752. https://doi.org/10.1111/bjd.20950

Working in partnership with the patient community to develop outline trial designs in CF (2021)
Journal Article
Rowbotham, N. J., Smith, S., Davies, G., Leighton, P., Rayner, O., Elliott, Z., …Smyth, A. R. (2022). Working in partnership with the patient community to develop outline trial designs in CF. Journal of Cystic Fibrosis, 21(2), 300-301. https://doi.org/10.1016/j.jcf.2021.12.008

In a collaboration between health professionals and the patient community, we previously identified the Top 10 priorities for clinical research in CF [ [1] ]. Here, we have used a similar approach to explore four of these priorities further and sugge... Read More about Working in partnership with the patient community to develop outline trial designs in CF.

Multifactorial falls prevention programme compared with usual care in UK care homes for older people: Multicentre cluster randomised controlled trial with economic evaluation (2021)
Journal Article
Logan, P. A., Horne, J. C., Gladman, J. R., Gordon, A. L., Robertson, K., Sach, T., …Sims, E. (2021). Multifactorial falls prevention programme compared with usual care in UK care homes for older people: Multicentre cluster randomised controlled trial with economic evaluation. BMJ, 375, Article e066991. https://doi.org/10.1136/bmj-2021-066991

Objectives To determine the clinical and cost effectiveness of a multifactorial fall prevention programme compared with usual care in long term care homes. Design Multicentre, parallel, cluster randomised controlled trial. Setting Long term care home... Read More about Multifactorial falls prevention programme compared with usual care in UK care homes for older people: Multicentre cluster randomised controlled trial with economic evaluation.

Capsule formation around breast implants (2021)
Journal Article
Bayston, R. (2022). Capsule formation around breast implants. Journal of Plastic, Reconstructive and Aesthetic Surgery, 31, 123-128. https://doi.org/10.1016/j.jpra.2021.11.004

All implants are rapidly coated by the host with glycoproteins forming a thin capsule, and this is a normal response. Where an inflammatory stimulus such as infection is present, the capsule can thicken and become microvascularised and sometimes calc... Read More about Capsule formation around breast implants.

Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study) (2021)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., Abdul-Wahab, A., …Thomas, K. S. (2022). Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study). British Journal of Dermatology, 186(2), 341-351. https://doi.org/10.1111/bjd.20689

Background In children, psoriasis can be challenging to diagnose. Difficulties arise from differences in the clinical presentation compared to adults. Objectives To test the diagnostic accuracy of previously agreed consensus criteria and develop... Read More about Identifying the best predictive diagnostic criteria for psoriasis in children (< 18 years): a UK multicentre case–control diagnostic accuracy study (DIPSOC study).

The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids (2021)
Journal Article
Vijay, A., Kouraki, A., Gohir, S., Turnbull, J., Kelly, A., Chapman, V., …Valdes, A. M. (2021). The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids. Gut Microbes, 13(1), Article 1997559. https://doi.org/10.1080/19490976.2021.1997559

The endocannabinoid (EC) system has pleiotropic functions in the body. It plays a key role in energy homeostasis and the development of metabolic disorders being a mediator in the relationship between the gut microbiota and host metabolism. In the cu... Read More about The anti-inflammatory effect of bacterial short chain fatty acids is partially mediated by endocannabinoids.

Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis (2021)
Journal Article
Hasanaj, A., Zaki, F., Harman, K. E., Grindlay, D., & Gran, S. (2022). Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis. British Journal of Dermatology, 186(2), 359-361. https://doi.org/10.1111/bjd.20759

Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are autoimmune blistering skin disorders which are increasing in incidence and are associated with high mortality. 1,2 As people with BP and PV often have comorbidity and require treatment that ha... Read More about Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review and meta-analysis.

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 (2021)
Journal Article
Swadling, L., Diniz, M. O., Schmidt, N. M., Amin, O. E., Chandran, A., Shaw, E., …Investigators, C. (2022). Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2. Nature, 601(7891), 110-117. https://doi.org/10.1038/s41586-021-04186-8

Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells can contribute to the rapid clearance of SARS-CoV-2 and other cor... Read More about Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.

Trends in hospital admissions for childhood fractures in England (2021)
Journal Article
Marson, B. A., Manning, J. C., James, M., Ikram, A., Bryson, D. J., & Ollivere, B. J. (2021). Trends in hospital admissions for childhood fractures in England. BMJ Paediatrics Open, 5(1), Article e001187. https://doi.org/10.1136/bmjpo-2021-001187

Purpose Fractures to the axial and appendicular skeleton are common in children causing loss of opportunities and disability. There are relatively few studies available to quantify the number of children who have their fractures diagnosed in the emer... Read More about Trends in hospital admissions for childhood fractures in England.

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia (2021)
Journal Article
Lillywhite, A., Woodhams, S. G., Gonçalves, S. V., Watson, D. J. G., Li, L., Burston, J. J., …Chapman, V. (2021). Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia. PAIN Reports, 6(4), Article e956. https://doi.org/10.1097/PR9.0000000000000956

Introduction: Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises.... Read More about Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia.

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Zhang, W., …Abhishek, A. (2022). Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology, 61(7), 2783-2791. https://doi.org/10.1093/rheumatology/keab790

OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respect... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.

Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study (2021)
Journal Article
Bradshaw, L. E., Haines, R. H., Thomas, K. S., Chalmers, J. R., Irvine, A. D., Williams, H. C., & Brown, S. J. (2021). Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study. Clinical and Experimental Allergy, 51(11), 1421-1428. https://doi.org/10.1111/cea.14025

Background: Palmar hyperlinearity is a feature of ichthyosis vulgaris, the monogenic skin disorder caused by FLG loss-of-function mutations. Objective: To investigate how well the presence or absence of hyperlinear palms (HLP) detect FLG genotype in... Read More about Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study.

Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation (2021)
Journal Article
Al-Awadi, A., Grove, J., Taylor, M., Valdes, A., Vijay, A., Bawden, S., …Aithal, G. (2021). Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation. BMJ Open, 11(10), Article e045802. https://doi.org/10.1136/bmjopen-2020-045802

Introduction A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipo... Read More about Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation.

Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study (2021)
Journal Article
Persson, M. S., Harman, K. E., Thomas, K. S., Chalmers, J. R., Vinogradova, Y., Langan, S. M., …Gran, S. (2021). Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study. British Journal of General Practice, 71(713), e904-e911. https://doi.org/10.3399/BJGP.2020.0870

Background: Oral prednisolone is the mainstay treatment for bullous pemphigoid, an autoimmune blistering skin disorder affecting older people. Treatment with moderate-to-high doses is often initiated in secondary care, but then continued in primary c... Read More about Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study.

Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs (2021)
Journal Article
Collier, F., Howes, R., Rodrigues, J., Thomas, K. S., Leighton, P., & Ingram, J. R. (2021). Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs. BJGP Open, 5(5), 1-8. https://doi.org/10.3399/BJGPO.2021.0051

Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that causes painful discharging nodules and skin tunnels. HS has associations with several systemic diseases, including cardiovascular disease (CVD), anxiety, and depress... Read More about Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs.

A Systematic Review of the Biological Effects of Cordycepin (2021)
Journal Article
Radhi, M., Ashraf, S., Lawrence, S., Tranholm, A. A., Wellham, P. A. D., Hafeez, A., …De Moor, C. H. (2021). A Systematic Review of the Biological Effects of Cordycepin. Molecules, 26(19), Article 5886. https://doi.org/10.3390/molecules26195886

We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 Fe... Read More about A Systematic Review of the Biological Effects of Cordycepin.

Exploring the challenges of accessing medication for patients with cystic fibrosis (2021)
Journal Article
Herbert, S., Rowbotham, N., Smith, S., Wilson, P., Elliott, Z., Leighton, P., …Smyth, A. R. (2022). Exploring the challenges of accessing medication for patients with cystic fibrosis. Thorax, 77(3), 295-297. https://doi.org/10.1136/thoraxjnl-2021-217140

Reducing treatment burden in cystic fibrosis (CF) is the top research priority for patients and clinicians. Difficulty accessing medication is one aspect of treatment burden. We investigated this with an online survey available globally for patients... Read More about Exploring the challenges of accessing medication for patients with cystic fibrosis.

The global incidence of bullous pemphigoid: a systematic review and meta-analysis (2021)
Journal Article
Persson, M. S., Begum, N., Grainge, M. J., Harman, K. E., Grindlay, D., & Gran, S. (2022). The global incidence of bullous pemphigoid: a systematic review and meta-analysis. British Journal of Dermatology, 186(3), 414-425. https://doi.org/10.1111/bjd.20743

Background: Bullous pemphigoid (BP) is an autoimmune blistering disorder that mainly affects older people. Although the disease is associated with considerable morbidity and mortality, the burden of disease worldwide is unclear. Objectives: The study... Read More about The global incidence of bullous pemphigoid: a systematic review and meta-analysis.

Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women (2021)
Journal Article
Renz, S., Chinnery, F., Stuart, B., Day, L., Muller, I., Soulsby, I., …Santer, M. (2021). Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women. BMJ Open, 11(8), Article e053876. https://doi.org/10.1136/bmjopen-2021-053876

Introduction Acne is one of the most common inflammatory skin diseases worldwide and can have significant psychosocial impact and cause permanent scarring. Spironolactone, a potassium-sparing diuretic, has antiandrogenic properties, potentially reduc... Read More about Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women.