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Metabolic signatures of osteoarthritis in urine using liquid chromatography‐high resolution tandem mass spectrometry (2021)
Journal Article
Abdelrazig, S., Ortori, C. A., Doherty, M., Valdes, A. M., Chapman, V., & Barrett, D. A. (2021). Metabolic signatures of osteoarthritis in urine using liquid chromatography‐high resolution tandem mass spectrometry. Metabolomics, 17(3), Article 29. https://doi.org/10.1007/s11306-021-01778-3

Introduction: Osteoarthritis (OA) is a common cause of disability in older people, but its aetiology is not yet fully understood. Biomarkers of OA from metabolomics studies have shown potential use in understanding the progression and pathophysiology... Read More about Metabolic signatures of osteoarthritis in urine using liquid chromatography‐high resolution tandem mass spectrometry.

Promoting Evidence-based Veterinary Medicine through the online resource ‘EBVM Learning’: User feedback (2021)
Journal Article
Sellers, E., Baillie, S., Dean, R., Warman, S., Janicke, H., Arlt, S. P., Boulton, C., Brennan, M., Brodbelt, D., Brown, F., Buckley, L., Du, M., Gallop, E., Goran, G., Grindlay, D. J., Haddock, L., Ireland, J., McGowan, C., Moberly, H. K., Place, E., …Verheyen, K. (2021). Promoting Evidence-based Veterinary Medicine through the online resource ‘EBVM Learning’: User feedback. Veterinary Evidence, 6(1), 1-17. https://doi.org/10.18849/ve.v6i1.392

‘EBVM Learning’ is a freely available resource created in 2015 by an international team with the support of RCVS Knowledge. The resource comprises a series of online modules teaching the fundamental concepts of evidence-based veterinary medicine (EBV... Read More about Promoting Evidence-based Veterinary Medicine through the online resource ‘EBVM Learning’: User feedback.

Skin care interventions in infants for preventing eczema and food allergy: a Cochrane systematic review and individual participant data meta‐analysis (2021)
Journal Article
Kelleher, M. M., Cro, S., Van Vogt, E., Cornelius, V., Lodrup Carlsen, K. C., Skjerven, H. O., Rehbinder, E. M., Lowe, A., Dissanayake, E., Shimojo, N., Yonezawa, K., Ohya, Y., Yamamoto‐Hanada, K., Morita, K., Cork, M., Cooke, A., Simpson, E. L., McClanahan, D., Weidinger, S., Schmitt, J., …Boyle, R. J. (2021). Skin care interventions in infants for preventing eczema and food allergy: a Cochrane systematic review and individual participant data meta‐analysis. Clinical and Experimental Allergy, 51(3), 402-418. https://doi.org/10.1111/cea.13847

The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain (2021)
Journal Article
Akin-Akinyosoye, K., James, R. J. E., Mcwilliams, D. F., Millar, B., Das Nair, R., Ferguson, E., & Walsh, D. A. (2021). The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain. Osteoarthritis and Cartilage, 29(6), 802-814. https://doi.org/10.1016/j.joca.2021.02.562

OBJECTIVES: Pain is the prevailing symptom of knee osteoarthritis. Central sensitisation creates discordance between pain and joint pathology. We previously reported a central pain mechanisms trait derived from 8 discrete characteristics: neuropathic... Read More about The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain.

Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19 (2021)
Journal Article
Yan, H., Vijay, A., Jiang, F., Zheng, N., Hu, Y., Ye, H., Ollivere, B., Cai, T., Valdes, A. M., & Aithal, G. P. (2021). Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19. Endocrinology, Diabetes and Metabolism, 4(2), Article e00215. https://doi.org/10.1002/edm2.215

Background: COVID-19 has a broad clinical specturm. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity.
Methods: Clinical and la... Read More about Serum glucose, lactate dehydrogenase and hypertension are mediators of the 1 effect of body mass index on severity of COVID-19.

Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis (2021)
Journal Article
Kirby, L., Gran, S., Kreuser-Genis, I., Owen, C., & Simpson, R. (2021). Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis. Skin Health and Disease, 1(1), Article e13. https://doi.org/10.1002/ski2.13

Background
Lichen sclerosus (LS) is a scarring chronic inflammatory disease with a predilection for genital skin in both sexes. The aetiology of LS is controversial, but evidence increasingly suggests that the occluded exposure of susceptible epith... Read More about Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis.

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome (2021)
Journal Article
Menni, C., Louca, P., Berry, S. E., Vijay, A., Astbury, S., Leeming, E. R., Gibson, R., Asnicar, F., Piccinno, G., Wolf, J., Davies, R., Mangino, M., Segata, N., Spector, T. D., & Valdes, A. M. (2021). High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome. BMC Medicine, 19, 1-10. https://doi.org/10.1186/s12916-021-01913-w

Background: Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19.
Methods: Here, we assessed th... Read More about High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome.

Skin care interventions in infants for preventing eczema and food allergy (2021)
Journal Article
Kelleher, M. M., Cro, S., Cornelius, V., Lodrup Carlsen, K. C., Skjerven, H. O., Rehbinder, E. M., Lowe, A. J., Dissanayake, E., Shimojo, N., Yonezawa, K., Ohya, Y., Yamamoto-Hanada, K., Morita, K., Axon, E., Surber, C., Cork, M., Cooke, A., Tran, L., Van Vogt, E., Schmitt, J., …Boyle, R. J. (2021). Skin care interventions in infants for preventing eczema and food allergy. Cochrane Library, 2021(2), Article CD013534. https://doi.org/10.1002/14651858.cd013534.pub2

Background

Eczema and food allergy are common health conditions that usually begin in early childhood and often occur together in the same people. They can be associated with an impaired skin barrier in early infancy. It is unclear whether trying... Read More about Skin care interventions in infants for preventing eczema and food allergy.

Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers (2021)
Journal Article
Muller, I., Stuart, B., Sach, T., Hooper, J., Wilczynska, S., Steele, M., Greenwell, K., Sivyer, K., Yardley, L., Williams, H. C., Chalmers, J. R., Leighton, P., Howells, L. M., Ridd, M. J., Lawton, S., Griffiths, G., Nuttall, J., Langan, S. M., Roberts, A., Ahmed, A., …Santer, M. (2021). Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers. BMJ Open, 11(2), Article e045583. https://doi.org/10.1136/bmjopen-2020-045583

Introduction Eczema care requires management of triggers and various treatments. We developed two online behavioural interventions to support eczema care called ECO (Eczema Care Online) for young people and ECO for families. This protocol describes t... Read More about Supporting self-care for eczema: protocol for two randomised controlled trials of ECO (Eczema Care Online) interventions for young people and parents/carers.

Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England (2021)
Journal Article
Persson, M., Harman, K., Thomas, K., Chalmers, J., Vinogradova, Y., Langan, S., Hippisley-Cox, J., & Gran, S. (2021). Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England. BMC Medical Research Methodology, 21(1), Article 22. https://doi.org/10.1186/s12874-021-01212-1

Background
Trials of novel agents are required to improve the care of patients with rare diseases, but trial feasibility may be uncertain due to concerns over insufficient patient numbers. We aimed to determine the size of the pool of potential part... Read More about Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England.

Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review (2021)
Journal Article
Deshmukh, S. R., Mousoulis, C., Marson, B. A., Grindlay, D., Karantana, A., the Core Outcome Set for Hand Fractures and Joint Injuries in Adults Group, Leighton, P., & Montgomery, A. A. (2021). Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review. Journal of Hand Surgery (European Volume), 46(5), 488-495. https://doi.org/10.1177/1753193420983719

© The Author(s) 2021. This study identifies the treatment outcome domains used in recently published studies on the treatment of hand fractures and joint injuries with the aim to inform development of a core outcome set. Seven databases were searched... Read More about Developing a core outcome set for hand fractures and joint injuries in adults: a systematic review.

The German RECAP questionnaire: linguistic validation and cognitive debriefing in German adults with self-reported atopic eczema and parents of affected children (2021)
Journal Article
Gabes, M., Tischer, C., Herrmann, A., Howells, L., & Apfelbacher, C. (2021). The German RECAP questionnaire: linguistic validation and cognitive debriefing in German adults with self-reported atopic eczema and parents of affected children. Journal of Patient-Reported Outcomes, 5(1), Article 13. https://doi.org/10.1186/s41687-021-00285-2

Background
Recap of atopic eczema (RECAP) is a patient-reported outcome measure (PROM) assessing eczema control. Long-term control of eczema is one of the four core outcome domains for atopic eczema trials. This instrument has been recently develope... Read More about The German RECAP questionnaire: linguistic validation and cognitive debriefing in German adults with self-reported atopic eczema and parents of affected children.

Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative (2021)
Journal Article
Aso, K., Shahtaheri, S. M., McWilliams, D. F., & Walsh, D. A. (2021). Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Research and Therapy, 23, Article 35. https://doi.org/10.1186/s13075-021-02422-0

© 2021, The Author(s). Background: Subchondral bone marrow lesions (BMLs) detected on MRI in knee osteoarthritis (OA) are associated with knee pain. The prevalence and progression of subchondral BMLs are increased by mechanical knee load. However, as... Read More about Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative.

Test‐guided dietary management of eczema in children: A randomized controlled feasibility trial (TEST) (2021)
Journal Article
Ridd, M. J., Webb, D., Roberts, K., Santer, M., Chalmers, J. R., Gilbertson, A., Marriage, D., Blair, P. S., Turner, N. L., Garfield, K., Coast, J., Selman, L. E., Clement, C., Shaw, A. R., Muller, I., Waddell, L., Angier, E., Taylor, J., Kai, J., & Boyle, R. J. (2021). Test‐guided dietary management of eczema in children: A randomized controlled feasibility trial (TEST). Clinical and Experimental Allergy, 51(3), 452-462. https://doi.org/10.1111/cea.13816

Background
Parents commonly ask about food allergy tests, to find a cause for their child's eczema, yet the value of routine testing is uncertain.

Objective
To determine whether a clinical trial comparing test‐guided dietary advice versus usual... Read More about Test‐guided dietary management of eczema in children: A randomized controlled feasibility trial (TEST).

Can patient characteristics explain variance in ultrasound strain elastography measures of the quadratus femoris and patellar tendons? (2021)
Journal Article
Dickson, D. M., Smith, S. L., & Hendry, G. J. (2021). Can patient characteristics explain variance in ultrasound strain elastography measures of the quadratus femoris and patellar tendons?. Knee, 28, 282-293. https://doi.org/10.1016/j.knee.2020.12.011

Objectives To explore the associations between participant characteristics and magnitudes of difference in paired elastography measures of knee tendon from different ultrasound systems, and to compare strain elastography pattern description. Material... Read More about Can patient characteristics explain variance in ultrasound strain elastography measures of the quadratus femoris and patellar tendons?.

Using a comprehensive audit to identify local context prior to care bundle design and implementation for inadvertent perioperative hypothermia in colorectal surgery (2021)
Journal Article
Tanner, J., Timmons, S., Bayston, R., Adams, K., & Baxendale, B. (2021). Using a comprehensive audit to identify local context prior to care bundle design and implementation for inadvertent perioperative hypothermia in colorectal surgery. BMJ Open Quality, 10(1), Article e001132. https://doi.org/10.1136/bmjoq-2020-001132

© Background The first step in bundle design or implementation is to identify the problem being addressed. Several validated approaches are recommended to facilitate this. These include using systematic reviews, adverse event triggers and risk asses... Read More about Using a comprehensive audit to identify local context prior to care bundle design and implementation for inadvertent perioperative hypothermia in colorectal surgery.

Efficacy and safety of multiple intra-articular corticosteroid injections for osteoarthritis—a systematic review and meta-analysis of randomized controlled trials and observational studies (2021)
Journal Article
Ayub, S., Kaur, J., Espahbodi, S., Hall, M., Doherty, M., & Zhang, W. (2021). Efficacy and safety of multiple intra-articular corticosteroid injections for osteoarthritis—a systematic review and meta-analysis of randomized controlled trials and observational studies. Rheumatology, 60(4), 1629–1639. https://doi.org/10.1093/rheumatology/keaa808

Objectives
To investigate the efficacy and safety of multiple intra-articular corticosteroid (IACS) injections for the treatment of OA.

Methods
We conducted electronic searches of several databases for randomized controlled trials (RCTs) and obs... Read More about Efficacy and safety of multiple intra-articular corticosteroid injections for osteoarthritis—a systematic review and meta-analysis of randomized controlled trials and observational studies.

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals (2021)
Journal Article
Asnicar, F., Berry, S. E., Valdes, A. M., Nguyen, L. H., Piccinno, G., Drew, D. A., Leeming, E., Gibson, R., Le Roy, C., Khatib, H. A., Francis, L., Mazidi, M., Mompeo, O., Valles-Colomer, M., Tett, A., Beghini, F., Dubois, L., Bazzani, D., Thomas, A. M., Mirzayi, C., …Segata, N. (2021). Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nature Medicine, 27, 321–332. https://doi.org/10.1038/s41591-020-01183-8

The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Perso... Read More about Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.

Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting (2021)
Journal Article
Thomas, K., Apfelbacher, C., Chalmers, J., Simpson, E., Spuls, P., Gerbens, L., Williams, H., Schmitt, J., Gabes, M., Howells, L., Stuart, B., Grinich, E., Pawlitschek, T., Burton, T., Howie, L., Gadkari, A., Eckert, L., Ebata, T., Boers, M., Saeki, H., …Katoh, N. (2021). Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting. British Journal of Dermatology, 185(1), 139-146. https://doi.org/10.1111/bjd.19751

Background: The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains for atopic eczema (AE) clinical trials. Previous consensus meetings have agreed on preferred instruments for clinician-reported si... Read More about Recommended core outcome instruments for health‐related quality of life, long‐term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.