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Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M., Valdes, A., Townsend, N., Mallen, C., Zhang, W., Doherty, M., Mamas, M., & Abhishek, A. (2019). Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink. BMJ Open, 9(8), Article e032050. https://doi.org/10.1136/bmjopen-2019-032050

© Author(s) (or their employer(s)) 2019. Introduction: To investigate if β-adrenoreceptor blocking drug (β-blocker) prescription reduces the risk of knee or hip osteoarthritis, total joint replacement and analgesic prescription. Setting: Primary care... Read More about Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink.

An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study (2019)
Journal Article
Baystson, R., Ashraf, W., Pelegrin, I., Fowkes, K., Bienemann, A. S., Singleton, W. G., & Scott, I. S. (2019). An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study. Journal of Antimicrobial Chemotherapy, 74(10), 2959-2964. https://doi.org/10.1093/jac/dkz293

© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. BACKGROUND: External ventricular drainage (EVD) carries a high risk of ventriculitis, increasingly caused by MDR Gram-negative... Read More about An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against multi-drug-resistant Gram negative bacteria: an in vitro and in vivo study.

Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma (2019)
Journal Article
Dinnes, J., Ferrante Di Ruffano, L., Takwoingi, Y., Cheung, S. T., Nathan, P., Matin, R. N., Chuchu, N., Chan, S. A., Durack, A., Bayliss, S. E., Gulati, A., Patel, L., Davenport, C., Godfrey, K., Subesinghe, M., Traill, Z., Deeks, J. J., & Williams, H. C. (2019). Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma. Cochrane Database of Systematic Reviews, 2019(7), Article CD012806. https://doi.org/10.1002/14651858.CD012806.pub2

© 2019 The Cochrane Collaboration. Background Melanoma is one of the most aggressive forms of skin cancer, with the potential to metastasise to other parts of the body via the lymphatic system and the bloodstream. Melanoma accounts for a small percen... Read More about Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma.

Different strategies for using topical corticosteroids in people with eczema (2019)
Journal Article
Chalmers, J. R., Axon, E., Harvey, J., Santer, M., Ridd, M. J., Lawton, S., Langan, S., Roberts, A., Ahmed, A., Muller, I., Long, C. M., Panda, S., Chernyshov, P., Carter, B., Williams, H. C., & Thomas, K. S. (2019). Different strategies for using topical corticosteroids in people with eczema. Cochrane Database of Systematic Reviews, 2019(6), Article CD013356. https://doi.org/10.1002/14651858.CD013356

© 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To establish the effectiveness and safety of different ways of using topical corticoster... Read More about Different strategies for using topical corticosteroids in people with eczema.

Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis (2019)
Journal Article
Pearson, R. G., Masud, T., Blackshaw, E., Naylor, A., Hinchcliffe, M., Jeffery, K., Jordan, F., Shabir-Ahmed, A., King, G., Lewis, A. L., Illum, L., & Perkins, A. C. (2019). Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis. Pharmaceutics, 11(6), Article 265. https://doi.org/10.3390/pharmaceutics11060265

Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream. Previously, we have published an encouraging bioavailability (78%), relati... Read More about Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis.

Predictors of placebo response to local (intra-articular) therapy in osteoarthritis: An individual patient data meta-analysis protocol (2019)
Journal Article
Yu, S. P. C., Ferreira, M. L., Van Middelkoop, M., Bierma-Zeinstra, S. M., Zhang, W., Deveza, L. A., & Hunter, D. J. (2019). Predictors of placebo response to local (intra-articular) therapy in osteoarthritis: An individual patient data meta-analysis protocol. BMJ Open, 9(5), 1-6. https://doi.org/10.1136/bmjopen-2018-027372

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction Osteoarthritis (OA) is a highly prevalent and disabling condition with limited safe and effecti... Read More about Predictors of placebo response to local (intra-articular) therapy in osteoarthritis: An individual patient data meta-analysis protocol.

Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis (2019)
Journal Article
Goh, S.-L., Persson, M. S., Stocks, J., Hou, Y., Lin, J., Hall, M. C., Doherty, M., & Zhang, W. (2019). Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis. Annals of Physical and Rehabilitation Medicine, 62(5), 356-365. https://doi.org/10.1016/j.rehab.2019.04.006

Background. Exercise is an effective treatment for osteoarthritis. However, the effect may vary from one patient (or study) to another.

Objective. To evaluate the efficacy of exercise and its potential determinants for pain, function, performance,... Read More about Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis.

The outcome of bone graft surgery for nonunion of fractures of the scaphoid (2019)
Journal Article
Ammori, M. B., Elvey, M., Mahmoud, S. S., Nicholls, A. J., Robinson, S., Rowan, C., Spence, S., Wade, R. G., Karantana, A., & Davis, T. R. (2019). The outcome of bone graft surgery for nonunion of fractures of the scaphoid. Journal of Hand Surgery (European Volume), 44(7), 676-684. https://doi.org/10.1177/1753193419841278

© The Author(s) 2019. Data on 806 patients undergoing bone graft surgery for a scaphoid fracture nonunion were retrospectively collected at 19 centres in the United Kingdom. Each centre contributed at least 30 cases. Sufficient data were available in... Read More about The outcome of bone graft surgery for nonunion of fractures of the scaphoid.

Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort (2019)
Journal Article
Chalmers, J., Ban, L., Leena, K., Edwards, K., Grove, J., Aithal, G., & Shenoy, K. (2019). Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort. BMJ Open, 9(5), Article e027244. https://doi.org/10.1136/bmjopen-2018-027244

Purpose
The Trivandrum NAFLD cohort is a population-based study designed to examine the interaction between genetic and lifestyle factors and their association with increased risk of NAFLD within the Indian population.
Participants
Between 201... Read More about Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort.

Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data (2019)
Presentation / Conference Contribution
Stocks, J., Persson, M., van Middelkoop, M., Bierma-Zeinstra, S., Runhaar, J., Sawitzke, A., McAlindon, T., Atchia, I., Lambert, R., Hashem Hasempur, M., Walsh, D., Doherty, M., & Zhang, W. (2019, May). Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data. Presented at 2019 World Congress on Osteoarthritis, Toronto, Canada

Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae (2019)
Presentation / Conference Contribution
McWilliams, D., Rahman, S., James, R., Ferguson, E., Kiely, P., Young, A., & Walsh, D. (2019, April). Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae. Poster presented at Rheumatology 2019, Birmingham, UK

Background
RA flares are common and disabling. They are described in terms of worsening pain, swelling, or other symptoms. We aimed to determine characteristics, antecedants and sequelae of painful and inflammatory flare subtypes during the first 11... Read More about Disease Activity Flares and Pain Flares in an early rheumatoid arthritis inception cohort; characteristics, antecedants and sequelae.

Self-report central mechanisms trait predicts knee pain persistence in the Knee Pain In the Community (KPIC) cohort (2019)
Presentation / Conference Contribution
McWilliams, D., Akin-Akinyosoye, K., Walsh, D., Frowd, N., Swaithes, L., Fernandes, G., Stocks, J., Sarmanova, A., Zhang, W., Doherty, M., Valdes, A., & Ferguson, E. (2019, April). Self-report central mechanisms trait predicts knee pain persistence in the Knee Pain In the Community (KPIC) cohort. Poster presented at Rheumatology 2019, Birmingham, UK

Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M. J., Myles, P., Mallen, C. D., Zhang, W., Doherty, M., Nguyen-Van-Tam, J. S., & Abhishek, A. (2019). Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 78(8), 1122-1126. https://doi.org/10.1136/annrheumdis-2019-215086

Objectives To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis, and unexplained fever in people w... Read More about Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink.

Do antibiotic impregnated calcium sulphate beads improve the healing of neuropathic foot ulcers with osteomyelitis undergoing surgical debridement? (2019)
Journal Article
Dekker, A., Uzoho, C., & Scammell, B. (2019). Do antibiotic impregnated calcium sulphate beads improve the healing of neuropathic foot ulcers with osteomyelitis undergoing surgical debridement?. Wounds, 31(6), 145–150

Background: Neuropathic foot ulcers are common and difficult to treat. Calcium sulphate has been used for antibiotic delivery with success in treating osteomyelitis. Recent case series suggest success in treating osteomyelitis of the foot with a mean... Read More about Do antibiotic impregnated calcium sulphate beads improve the healing of neuropathic foot ulcers with osteomyelitis undergoing surgical debridement?.

Machine-learning for osteoarthritis research (2019)
Journal Article
Kluzek, S., & Mattei, T. (2019). Machine-learning for osteoarthritis research. Osteoarthritis and Cartilage, 27(7), 977-978. https://doi.org/10.1016/j.joca.2019.04.005

Machine learning (ML) algorithms have the ability to automatically learn and improve from experience without being specifically directed. There has been great optimism that such techniques may improve scientific biomedical research in several fields1... Read More about Machine-learning for osteoarthritis research.

Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model (2019)
Journal Article
McLaren, J. S., Macri-Pellizzeri, L., Zakir Hossain, K. M., Patel, U., Grant, D. M., Scammell, B. E., Ahmed, I., & Sottile, V. (2019). Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model. ACS Applied Materials and Interfaces, 11(17), 15436–15446. https://doi.org/10.1021/acsami.9b04603

Phosphate-based glasses (PBG) are bioactive and fully degradable materials with tailorable degradation rates. PBGs can be produced as porous microspheres through a single-step process, using changes in their formulation and geometry to produce varyin... Read More about Porous phosphate-based glass microspheres show biocompatibility, tissue infiltration and osteogenic onset in an ovine bone defect model.