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Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort

Chalmers, J.; Ban, L.; Leena, K.B.; Edwards, K.L.; Grove, J.I.; Aithal, G.P.; Shenoy, K.T.

Cohort profile: The Trivandrum Non-alcoholic Fatty Liver Disease (NAFLD) Cohort Thumbnail


Authors

J. Chalmers

L. Ban

K.B. Leena

KIMBERLEY EDWARDS KIMBERLEY.EDWARDS@NOTTINGHAM.AC.UK
Professor of Sport, exercise and Nutrition Education

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JANE GROVE jane.grove@nottingham.ac.uk
Assistant Professor

K.T. Shenoy



Abstract

Purpose
The Trivandrum NAFLD cohort is a population-based study designed to examine the interaction between genetic and lifestyle factors and their association with increased risk of NAFLD within the Indian population.
Participants
Between 2013 and 2016, 2222 participants were recruited to this cohort through multi-stage cluster sampling across the whole population of Trivandrum – a district within the state of Kerala, South India. Data was collected from all inhabitants of randomly-selected households over the age of 25.
Findings to date
Full baseline clinical and pathological data was collected from 2158 participants. This included detailed demographic profiles, anthropometric measures and lifestyle data (food frequency, physical activity and anxiety and depression questionnaires). Biochemical profile and ultrasound assessment of the liver were performed and whole blood aliquots were collected for DNA analysis.
The NAFLD prevalence within this population was 49.8% which is significantly higher than the global pooled prevalence of 25%. This highlights the importance of robust, prospective studies like this to enable collection of longitudinal data on risk factors, disease progression and to facilitate future interventional studies.
Future plans
The complete analysis of data collected from this cohort will give valuable insights into the interaction of the phenotypic and genotypic profiles that result in such a dramatic increased risk of NAFLD within the Indian population. The cohort will also form the basis of future lifestyle interventional studies, aimed at improving liver and metabolic health.

Journal Article Type Article
Acceptance Date Apr 2, 2019
Online Publication Date May 5, 2019
Publication Date May 5, 2019
Deposit Date Apr 18, 2019
Publicly Available Date May 10, 2019
Journal BMJ Open
Electronic ISSN 2044-6055
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 9
Issue 5
Article Number e027244
DOI https://doi.org/10.1136/bmjopen-2018-027244
Keywords General Medicine
Public URL https://nottingham-repository.worktribe.com/output/1828925
Publisher URL https://bmjopen.bmj.com/content/9/5/e027244