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Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia (2021)
Journal Article
Lillywhite, A., Woodhams, S. G., Gonçalves, S. V., Watson, D. J. G., Li, L., Burston, J. J., …Chapman, V. (2021). Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia. PAIN Reports, 6(4), Article e956. https://doi.org/10.1097/PR9.0000000000000956

Introduction: Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises.... Read More about Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia.

Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Zhang, W., …Abhishek, A. (2022). Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology, 61(7), 2783-2791. https://doi.org/10.1093/rheumatology/keab790

OBJECTIVE: To develop and validate a prognostic model for LEF discontinuation with abnormal blood test results. METHODS: Data from the Clinical Practice Research Datalink Gold and Aurum were used for model development and external validation, respect... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.

Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study (2021)
Journal Article
Bradshaw, L. E., Haines, R. H., Thomas, K. S., Chalmers, J. R., Irvine, A. D., Williams, H. C., & Brown, S. J. (2021). Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study. Clinical and Experimental Allergy, 51(11), 1421-1428. https://doi.org/10.1111/cea.14025

Background: Palmar hyperlinearity is a feature of ichthyosis vulgaris, the monogenic skin disorder caused by FLG loss-of-function mutations. Objective: To investigate how well the presence or absence of hyperlinear palms (HLP) detect FLG genotype in... Read More about Clinical examination for hyperlinear palms to determine filaggrin genotype: A diagnostic test accuracy study.

Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation (2021)
Journal Article
Al-Awadi, A., Grove, J., Taylor, M., Valdes, A., Vijay, A., Bawden, S., …Aithal, G. (2021). Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation. BMJ Open, 11(10), Article e045802. https://doi.org/10.1136/bmjopen-2020-045802

Introduction A Low Glycaemic Index (LGI) diet is a proposed lifestyle intervention in non-alcoholic fatty liver diseases (NAFLD) which is designed to reduce circulating blood glucose levels, hepatic glucose influx, insulin resistance and de novo lipo... Read More about Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): A study protocol of an efficacy mechanism evaluation.

Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study (2021)
Journal Article
Persson, M. S., Harman, K. E., Thomas, K. S., Chalmers, J. R., Vinogradova, Y., Langan, S. M., …Gran, S. (2021). Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study. British Journal of General Practice, 71(713), e904-e911. https://doi.org/10.3399/BJGP.2020.0870

Background: Oral prednisolone is the mainstay treatment for bullous pemphigoid, an autoimmune blistering skin disorder affecting older people. Treatment with moderate-to-high doses is often initiated in secondary care, but then continued in primary c... Read More about Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study.

Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs (2021)
Journal Article
Collier, F., Howes, R., Rodrigues, J., Thomas, K. S., Leighton, P., & Ingram, J. R. (2021). Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs. BJGP Open, 5(5), 1-8. https://doi.org/10.3399/BJGPO.2021.0051

Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that causes painful discharging nodules and skin tunnels. HS has associations with several systemic diseases, including cardiovascular disease (CVD), anxiety, and depress... Read More about Primary care management of hidradenitis suppurativa: a cross-sectional survey of UK GPs.

A Systematic Review of the Biological Effects of Cordycepin (2021)
Journal Article
Radhi, M., Ashraf, S., Lawrence, S., Tranholm, A. A., Wellham, P. A. D., Hafeez, A., …De Moor, C. H. (2021). A Systematic Review of the Biological Effects of Cordycepin. Molecules, 26(19), Article 5886. https://doi.org/10.3390/molecules26195886

We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 Fe... Read More about A Systematic Review of the Biological Effects of Cordycepin.

Exploring the challenges of accessing medication for patients with cystic fibrosis (2021)
Journal Article
Herbert, S., Rowbotham, N., Smith, S., Wilson, P., Elliott, Z., Leighton, P., …Smyth, A. R. (2022). Exploring the challenges of accessing medication for patients with cystic fibrosis. Thorax, 77(3), 295-297. https://doi.org/10.1136/thoraxjnl-2021-217140

Reducing treatment burden in cystic fibrosis (CF) is the top research priority for patients and clinicians. Difficulty accessing medication is one aspect of treatment burden. We investigated this with an online survey available globally for patients... Read More about Exploring the challenges of accessing medication for patients with cystic fibrosis.

Infections in CSF shunts and External Ventricular Drainage (2021)
Book Chapter
Bayston, R. (2022). Infections in CSF shunts and External Ventricular Drainage. In P. Kuru Bektaşoğlu, & B. Gürer (Eds.), Cerebrospinal Fluid. InTech. https://doi.org/10.5772/intechopen.98910

Infection in those with hydrocephalus shunts or external drains (EVDs) can cause serious central nervous system damage with lasting sequelae. The infections usually involve bacterial colonisation and biofilm formation in the catheters. The nature and... Read More about Infections in CSF shunts and External Ventricular Drainage.

The global incidence of bullous pemphigoid: a systematic review and meta-analysis (2021)
Journal Article
Persson, M. S., Begum, N., Grainge, M. J., Harman, K. E., Grindlay, D., & Gran, S. (2022). The global incidence of bullous pemphigoid: a systematic review and meta-analysis. British Journal of Dermatology, 186(3), 414-425. https://doi.org/10.1111/bjd.20743

Background: Bullous pemphigoid (BP) is an autoimmune blistering disorder that mainly affects older people. Although the disease is associated with considerable morbidity and mortality, the burden of disease worldwide is unclear. Objectives: The study... Read More about The global incidence of bullous pemphigoid: a systematic review and meta-analysis.

Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women (2021)
Journal Article
Renz, S., Chinnery, F., Stuart, B., Day, L., Muller, I., Soulsby, I., …Santer, M. (2021). Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women. BMJ Open, 11(8), Article e053876. https://doi.org/10.1136/bmjopen-2021-053876

Introduction Acne is one of the most common inflammatory skin diseases worldwide and can have significant psychosocial impact and cause permanent scarring. Spironolactone, a potassium-sparing diuretic, has antiandrogenic properties, potentially reduc... Read More about Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women.

Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection (2021)
Journal Article
Urbanowicz, R. A., Tsoleridis, T., Jackson, H. J., Cusin, L., Duncan, J. D., Chappell, J. G., …Ollivere, B. J. (2021). Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection. Science Translational Medicine, 13(609), Article eabj0847. https://doi.org/10.1126/scitranslmed.abj0847

Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necess... Read More about Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection.

What can we learn from the experiences and expectations of patients on growing waiting lists for planned care in the COVID-19 pandemic? (2021)
Journal Article
Kulkarni, K., Shah, R., Armaou, M., Leighton, P., Mangwani, J., & Dias, J. (2021). What can we learn from the experiences and expectations of patients on growing waiting lists for planned care in the COVID-19 pandemic?. Bone & Joint Open, 2(8), 583-593. https://doi.org/10.1302/2633-1462.28.bjo-2021-0056.r1

COVID-19 has compounded a growing waiting list problem, with over 4.5 million patients now waiting for planned elective care in the UK. Views of patients on waiting lists are rarely considered in prioritization. Our primary aim was to understand how... Read More about What can we learn from the experiences and expectations of patients on growing waiting lists for planned care in the COVID-19 pandemic?.

Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study (2021)
Journal Article
Nomikos, P. A., Hall, M., Fuller, A., Millar, B., Ogollah, R., Valdes, A., …Abhishek, A. (2021). Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study. BMJ Open, 11(7), Article e045242. https://doi.org/10.1136/bmjopen-2020-045242

Objectives To evaluate fidelity of delivery of a nurse-led non-pharmacological complex intervention for knee pain. Setting Secondary care. Single-centre study. Study design Mixed methods study. Participants Eighteen adults with chronic knee pain. Inc... Read More about Fidelity assessment of nurse-led non-pharmacological package of care for knee pain in the package development phase of a feasibility randomised controlled trial based in secondary care: A mixed methods study.

Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites (2021)
Journal Article
Vijay, A., Astbury, S., Panayiotis, L., Marques, F., Spector, T. D., Menni, C., & Valdes, A. M. (2021). Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites. Frontiers in Cardiovascular Medicine, 8, Article 691564. https://doi.org/10.3389/fcvm.2021.691564

Aims: The current study investigates the role of diet in mediating the gut microbiome-cardiovascular association which has not yet been explored in humans. Methods and results: Using a two-arm dietary intervention study in healthy participants (N=7... Read More about Dietary interventions reduce traditional and novel cardiovascular risk markers by altering the gut microbiome and their metabolites.

Safety of topical corticosteroids in atopic eczema: an umbrella review (2021)
Journal Article
Axon, E., Chalmers, J. R., Santer, M., Ridd, M. J., Lawton, S., Langan, S. M., …Thomas, K. S. (2021). Safety of topical corticosteroids in atopic eczema: an umbrella review. BMJ Open, 11(7), Article e046476. https://doi.org/10.1136/bmjopen-2020-046476

Objective An umbrella review summarising all safety data from systematic reviews of topical corticosteroids (TCS) in adults and children with atopic eczema. Methods Embase, MEDLINE, PubMed, Cochrane Database of Systematic Reviews and the Centre of Ev... Read More about Safety of topical corticosteroids in atopic eczema: an umbrella review.

The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis (2021)
Journal Article
McWilliams, D. F., Thankaraj, D., Jones-Diette, J., Morgan, R., Ifesemen, O. S., Shenker, N. G., & Walsh, D. A. (2022). The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis. Rheumatology, 61(1), 76-89. https://doi.org/10.1093/rheumatology/keab503

Objectives: Glucocorticosteroids (GCs) are recommended to suppress inflammation in people with active RA. This systematic review and meta-analysis aimed to quantify the effects of systemic GCs on RA pain. Methods: A systematic literature review of ra... Read More about The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis.

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model (2021)
Journal Article
Markides, H., Foster, N. C., McLaren, J. S., Hopkins, T., Black, C., Oreffo, R. O. C., …El Haj, A. J. (2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Cells, 10(7), Article 1776. https://doi.org/10.3390/cells10071776

The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based therapies is understanding th... Read More about Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model.

Protocol for surgical and non-surgical treatment for metacarpal shaft fractures in adults: an observational feasibility study (2021)
Journal Article
Taha, R., Leighton, P., Bainbridge, C., Montgomery, A., Davis, T., & Karantana, A. (2021). Protocol for surgical and non-surgical treatment for metacarpal shaft fractures in adults: an observational feasibility study. BMJ Open, 11, Article 046913. https://doi.org/10.1136/bmjopen-2020-046913

Introduction Metacarpal shaft fractures (MSF) are common traumatic hand injuries that usually affect young people of working age. They place a significant burden on healthcare resources and society, however there is a lack of evidence to guide thei... Read More about Protocol for surgical and non-surgical treatment for metacarpal shaft fractures in adults: an observational feasibility study.