Skip to main content

Research Repository

Advanced Search

All Outputs (77)

A review of standard pharmacological therapy for adult asthma - Steps 1 to 5 (2015)
Journal Article
Patel, M. D. K., & Shaw, D. E. (2015). A review of standard pharmacological therapy for adult asthma - Steps 1 to 5. Chronic Respiratory Disease, 12(2), https://doi.org/10.1177/1479972315573529

The aim of pharmacological therapy for asthma is to improve symptoms and lung function and minimise the risk of asthma attacks. The intensity of treatment is based on the level of asthma control and the potential risk of future deterioration. In th... Read More about A review of standard pharmacological therapy for adult asthma - Steps 1 to 5.

A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA) (2015)
Journal Article
Hodgson, D., Anderson, J., Reynolds, C., Meakin, G., Bailey, H., Pavord, I., …Harrison, T. W. (2015). A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA). Thorax, 70(6), 559-565. https://doi.org/10.1136/thoraxjnl-2014-206481

Background: Some patients with refractory asthma have evidence of uncontrolled eosinophilic inflammation in the distal airways. While traditional formulations of inhaled steroids settle predominantly in the large airways, newer formulations with an e... Read More about A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA).

A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work (2015)
Journal Article
Brown, M., Shaw, D. E., Sharples, S., Le Jeune, I., & Blakey, J. (2015). A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work. BMJ Open, 5(2), Article e006102. https://doi.org/10.1136/bmjopen-2014-006102

Objectives: The skill set required for junior doctors to work efficiently and safely Out of Hours (OoH) in hospitals has not been established. This is despite the OoH period representing 75% of the year and it being the time of highest mortality. We... Read More about A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work.

The use of ?2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis (2015)
Journal Article
Patel, M., Pilcher, J., Hancox, R. J., Sheahan, D., Pritchard, A., Braithwaite, I., …Beasley, R. (2015). The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis. npj Primary Care Respiratory Medicine, 25, 1-9. https://doi.org/10.1038/npjpcrm.2014.99

Background: Patterns of inhaled β2-agonist therapy use during severe asthma exacerbations before hospital attendance are poorly understood. Aims: To assess β2-agonist use prior to hospital attendance. Methods: We undertook an exploratory pos... Read More about The use of ?2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis.

Predictors of Severe Exacerbations, Poor Asthma Control, and ?-Agonist Overuse for Patients with Asthma (2014)
Journal Article
Beasley, R., Weatherall, M., Black, P., Shaw, D., Tranquilino, T., Mackey, B., …Black, P. (2014). Predictors of Severe Exacerbations, Poor Asthma Control, and β-Agonist Overuse for Patients with Asthma. Journal of Allergy and Clinical Immunology: In Practice, 2(6), 751-758.e1. https://doi.org/10.1016/j.jaip.2014.06.001

Background: Predictors of asthma exacerbations, poor asthma control, or extreme β-agonist overuse may be of clinical utility in the management of asthma. Objective: To investigate characteristics that predict subsequent adverse outcomes in asthm... Read More about Predictors of Severe Exacerbations, Poor Asthma Control, and ?-Agonist Overuse for Patients with Asthma.

The impact of azithromycin therapy on the airway microbiota in asthma (2014)
Journal Article
Slater, M., Rivett, D. W., Williams, L., Martin, M., Harrison, T. W., Sayers, I., …Shaw, D. E. (2014). The impact of azithromycin therapy on the airway microbiota in asthma. Thorax, 69(7), https://doi.org/10.1136/thoraxjnl-2013-204517

There is interest in the use of macrolide antibiotics in asthma. Macrolides have been shown to improve airway hyperresponsiveness (AHR) and measures of airway inflammation.The degree of AHR may relate to the microbiota present in the airways, with a... Read More about The impact of azithromycin therapy on the airway microbiota in asthma.

Respiratory muscle specific warm-up and elite swimming performance (2014)
Journal Article
Wilson, E. E., McKeever, T. M., Lobb, C., Sherriff, T., Gupta, L., Hearson, G., …Shaw, D. E. (2014). Respiratory muscle specific warm-up and elite swimming performance. British Journal of Sports Medicine, 48(9), https://doi.org/10.1136/bjsports-2013-092523

Background: Inspiratory muscle training has been shown to improve performance in elite swimmers, when used as part of routine training, but its use as a respiratory warm-up has yet to be investigated. Aim: To determine the influence of inspiratory m... Read More about Respiratory muscle specific warm-up and elite swimming performance.

Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma (2014)
Journal Article
Rogers, N. K., Clements, D., Dongre, A., Harrison, T. W., Shaw, D. E., & Johnson, S. R. (2014). Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma. PLoS ONE, 9(2), Article e90565. https://doi.org/10.1371/journal.pone.0090565

Airway remodelling describes the histopathological changes leading to fixed airway obstruction in patients with asthma and includes extra-cellular matrix (ECM) deposition. Matrix metalloproteinase-1 (MMP-1) is present in remodelled airways but its re... Read More about Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma.

Electronic monitoring of adherence to inhaled medication in asthma (2014)
Journal Article
Howard, S., Lang, A., Patel, M. D. K., Sharples, S., & Shaw, D. E. (2014). Electronic monitoring of adherence to inhaled medication in asthma. Current Respiratory Medicine Reviews, 10(1), https://doi.org/10.2174/1573398X10666140429005007

The main treatment of asthma is inhaled corticosteroids. However adherence to these medications in asthma is often poor, with low adherence associated with excessive health care costs and an increased risk of emergency room visits and mortality. Alth... Read More about Electronic monitoring of adherence to inhaled medication in asthma.

Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications (2013)
Journal Article
Hughes-Riley, T., Six, J. S., Lilburn, D., Stupic, K. F., Dorkes, A. C., Shaw, D. E., …Meersmann, T. (2013). Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications. Journal of Magnetic Resonance, 237, https://doi.org/10.1016/j.jmr.2013.09.008

As an alternative to cryogenic gas handling, hyperpolarized (hp) gas mixtures were extracted directly from the spin exchange optical pumping (SEOP) process through expansion followed by compression to ambient pressure for biomedical MRI applications.... Read More about Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications.

Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr (2013)
Journal Article
Six, J. S., Hughes-Riley, T., Lilburn, D. M., Dorkes, A. C., Stupic, K. F., Shaw, D. E., …Meersmann, T. (2014). Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr. Magnetic Resonance Imaging, 32(1), 48-53. https://doi.org/10.1016/j.mri.2013.08.007

Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarizati... Read More about Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr.

Metrics of salbutamol use as predictors of future adverse outcomes in asthma (2013)
Journal Article
Patel, M., Pilcher, J., Reddel, H. K., Pritchard, A., Corin, A., Helm, C., …Beasley, R. (2013). Metrics of salbutamol use as predictors of future adverse outcomes in asthma. Clinical and Experimental Allergy, 43(10), https://doi.org/10.1111/cea.12166

Background Beta-agonist overuse is associated with adverse outcomes in asthma, however, the relationships between different metrics of salbutamol use and future risk are uncertain. Objective To investigate the relationship between metrics of s... Read More about Metrics of salbutamol use as predictors of future adverse outcomes in asthma.

What drives the 'August effect'?: an observational study of the effect of junior doctor changeover on out of hours work (2013)
Journal Article
Blakey, J., Fearn, A., & Shaw, D. E. (2013). What drives the 'August effect'?: an observational study of the effect of junior doctor changeover on out of hours work. JRSM Short Reports, 4(8), https://doi.org/10.1177/2042533313489823

Objective: To investigate whether measurements of junior doctor on-call workload and performance can clarify the mechanisms underlying the increase in morbidity and mortality seen after junior doctor changeover: the ‘August effect’. Design: Quanti... Read More about What drives the 'August effect'?: an observational study of the effect of junior doctor changeover on out of hours work.

Short-acting ?-agonist use as a marker of current asthma control (2013)
Journal Article
Patel, M., Pilcher, J., Munro, C., Hosking, A., Pritchard, A., Shaw, D., …Beasley, R. (in press). Short-acting β-agonist use as a marker of current asthma control. Journal of Allergy and Clinical Immunology: In Practice, 1(4), https://doi.org/10.1016/j.jaip.2013.04.008

Background The relationship between current asthma symptoms and rescue bronchodilator (reliever) use is uncertain, leading to different recommendations about the preferred reliever metric to use when assessing asthma control. In a 6-month randomiz... Read More about Short-acting ?-agonist use as a marker of current asthma control.

Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial (2013)
Journal Article
Patel, M., Pilcher, J., Pritchard, A., Perrin, K., Travers, J., Shaw, D., …Beasley, R. (2013). Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial. Lancet Respiratory Medicine, 1(1), 32-42. https://doi.org/10.1016/S2213-2600%2813%2970007-9

Background The Single combination budesonide–formoterol inhaler Maintenance And Reliever Therapy (SMART) regimen reduces severe asthma exacerbations in patients, but whether the high doses of corticosteroid and β agonist increase the risk of adverse... Read More about Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial.

Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial (2012)
Journal Article
Patel, M., Pilcher, J., Travers, J., Perrin, K., Shaw, D., Black, P., …Beasley, R. (2013). Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial. Journal of Allergy and Clinical Immunology: In Practice, 1(1), https://doi.org/10.1016/j.jaip.2012.08.004

Background Electronic monitoring of inhaled asthma medications is one method to measure medication adherence and patterns of use. Information on the performance of monitors in a randomized controlled trial allows researchers and clinicians to unde... Read More about Use of metered-dose inhaler electronic monitoring in a real-world asthma randomized controlled trial.