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Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr

Six, Joseph S.; Hughes-Riley, Theodore; Lilburn, David M.L.; Dorkes, Alan C.; Stupic, Karl F.; Shaw, Dominick E.; Morris, Peter G.; Hall, Ian P.; Pavlovskaya, Galina E.; Meersmann, Thomas

Authors

Joseph S. Six

Theodore Hughes-Riley

David M.L. Lilburn

Alan C. Dorkes

Karl F. Stupic

IAN HALL ian.hall@nottingham.ac.uk
Professor of Molecular Medicine



Abstract

Hyperpolarized 83Kr has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the 83Kr hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched 83Kr, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized 83Kr MRI after krypton inhalation. Different 83Kr relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T1 weighted hyperpolarized 83Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast.

Citation

Six, J. S., Hughes-Riley, T., Lilburn, D. M., Dorkes, A. C., Stupic, K. F., Shaw, D. E., …Meersmann, T. (2014). Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized 83Kr. Magnetic Resonance Imaging, 32(1), https://doi.org/10.1016/j.mri.2013.08.007

Journal Article Type Article
Acceptance Date Aug 20, 2013
Online Publication Date Oct 18, 2013
Publication Date Jan 1, 2014
Deposit Date Feb 5, 2016
Publicly Available Date Feb 5, 2016
Journal Magnetic Resonance Imaging
Print ISSN 0730-725X
Electronic ISSN 1873-5894
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 32
Issue 1
DOI https://doi.org/10.1016/j.mri.2013.08.007
Keywords 83Kr; Krypton-83; Kr-83 hyperpolarization; Hyperpolarized;
Noble gas MRI; Spin polarization; Cryogenic separation; Spin-exchange optical pumping; Nuclear electric quadrupole moment; Quadrupolar relaxation; Surface sensitive contrast;
Pre-clinical MRI;
Public URL http://eprints.nottingham.ac.uk/id/eprint/31547
Publisher URL http://www.sciencedirect.com/science/article/pii/S0730725X13002890
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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