Skip to main content

Research Repository

Advanced Search

All Outputs (46)

Translating lung function genome-wide association study (GWAS) findings: new insights for lung biology (2016)
Journal Article
Kheirallah, A. K., Miller, S., Hall, I. P., & Sayers, I. (2016). Translating lung function genome-wide association study (GWAS) findings: new insights for lung biology. Current Advances in Genetics and Molecular Biology, 93, https://doi.org/10.1016/bs.adgen.2015.12.002

Chronic respiratory diseases are a major cause of worldwide mortality and morbidity. Although hereditary severe deficiency of ?1 antitrypsin (A1AD) has been established to cause emphysema, A1AD accounts for only ?1% of Chronic Obstructive Pulmonary D... Read More about Translating lung function genome-wide association study (GWAS) findings: new insights for lung biology.

The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma (2016)
Journal Article
Ketelaar, M. E., Nawijn, M. C., Shaw, D. E., Koppelman, G. H., & Sayers, I. (2016). The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma. Clinical and Experimental Allergy, 46(6), 884-887. https://doi.org/10.1111/cea.12718

Background Interleukin-33 (IL-33) has been subject of extensive study in the context of inflammatory disorders, particularly in asthma. Many human biological samples, including serum, have been used to determine the protein levels of IL-33, aiming t... Read More about The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma.

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12 (2016)
Journal Article
Jackson, V. E., Ntalla, I., Sayers, I., Morris, R., Whincup, P., Casas, J., …Wain, L. V. (in press). Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. Thorax, 71(6), https://doi.org/10.1136/thoraxjnl-2015-207876

Background Several regions of the genome have shown to be associated with COPD in genome-wide association studies of common variants. Objective To determine rare and potentially functional single nucleotide polymorphisms (SNPs) associated... Read More about Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Statistics of highly heterogeneous flow fields confined to three-dimensional random porous media (2016)
Journal Article
Jin, C., Langston, P. A., Pavlovskaya, G. E., Hall, M. R., & Rigby, S. P. (2016). Statistics of highly heterogeneous flow fields confined to three-dimensional random porous media. Physical Review E, 93(1), 1-10. https://doi.org/10.1103/PhysRevE.93.013122

© 2016 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and t... Read More about Statistics of highly heterogeneous flow fields confined to three-dimensional random porous media.

A predictive computational framework for direct reprogramming between human cell types (2016)
Journal Article
Rackham, O. J. L., Firas, J., Fang, H., Oates, M. E., Holmes, M. L., Knaupp, A. S., …KNOX, A. (2016). A predictive computational framework for direct reprogramming between human cell types. Nature Genetics, 48(3), 331-335. https://doi.org/10.1038/ng.3487

Transdifferentiation, the process of converting from one cell type to another without going through a pluripotent state, has great promise for regenerative medicine. The identification of key transcription factors for reprogramming is currently limit... Read More about A predictive computational framework for direct reprogramming between human cell types.