All Outputs (92)

The old and familiar meets the new and unknown: patient and clinician perceptions on e-cigarettes for smoking reduction in UK general practice, a qualitative interview study (2021)
Journal Article

Background and Aims: Clinicians could promote e-cigarettes for harm reduction to people who smoke but cannot stop, but many clinicians feel uneasy doing so. In a randomized controlled trial (RCT), primary care clinicians offered free e-cigarettes and... Read More about The old and familiar meets the new and unknown: patient and clinician perceptions on e-cigarettes for smoking reduction in UK general practice, a qualitative interview study.

Understanding the barriers and enablers of pharmacogenomic testing in primary care: a qualitative systematic review with meta-aggregation synthesis (2021)
Journal Article

Introduction: Pharmacogenomic testing can indicate which drugs may have limited therapeutic action or lead to adverse effects, hence guiding rational and safe prescribing. However, in the UK and other countries, there are still significant barriers t... Read More about Understanding the barriers and enablers of pharmacogenomic testing in primary care: a qualitative systematic review with meta-aggregation synthesis.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection (2021)
Journal Article

Although myocarditis and pericarditis were not observed as adverse events in coronavirus disease 2019 (COVID-19) vaccine trials, there have been numerous reports of suspected cases following vaccination in the general population. We undertook a self-... Read More about Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection.

Determining propensity for sub-optimal low-density lipoprotein cholesterol response to statins and future risk of cardiovascular disease (2021)
Journal Article

Background: Variability in low-density lipoprotein cholesterol (LDL-C) response to statins is underappreciated. We characterised patients by their statin response (SR), baseline risk of cardiovascular disease (CVD) and 10-year CVD outcomes. Method... Read More about Determining propensity for sub-optimal low-density lipoprotein cholesterol response to statins and future risk of cardiovascular disease.

Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): Study protocol (2021)
Journal Article

Background In the UK, postnatal depression is more common in British South Asian women than White Caucasion women. Cognitive-behavioural therapy (CBT) is recommended as a first-line treatment, but there is little evidence for the adaptation of CBT fo... Read More about Multicentre randomised controlled trial of a group psychological intervention for postnatal depression in British mothers of South Asian origin (ROSHNI-2): Study protocol.

Ethnicity and suicide risk: A population-based study from England (2021)
Journal Article

Using multiple linked electronic health databases, we conducted a large case-control study in England from 2001 through 2019 to examine the association between ethnicity and suicide risk. Asian, Black and Other ethnic groups had a significantly lower... Read More about Ethnicity and suicide risk: A population-based study from England.

Managing medicines at the end of life: a position paper for health policy and practice (2021)
Journal Article

Purpose: The impact of population ageing is significant, multifaceted and characterised by frailty and multi-morbidity. The COVID-19 pandemic has accelerated care pathways and policies promoting self-management and home-based care. One under-research... Read More about Managing medicines at the end of life: a position paper for health policy and practice.

Managing medicines at the end of life: a position paper for health policy and practice (2021)
Journal Article

Purpose The impact of population aging is significant, multifaceted and characterised by frailty and multi-morbidity. The COVID-19 pandemic has accelerated care pathways and policies promoting self-management and home-based care. One under-researched... Read More about Managing medicines at the end of life: a position paper for health policy and practice.

International consensus on clinical severity scale use in evaluating Niemann–Pick disease Type C in paediatric and adult patients: results from a Delphi Study (2021)
Journal Article

Background: Several scales have been developed in the past two decades to evaluate Niemann–Pick disease Type C (NPC) severity in clinical practice and trials. However, a lack of clarity concerning which scale to use in each setting is preventing the... Read More about International consensus on clinical severity scale use in evaluating Niemann–Pick disease Type C in paediatric and adult patients: results from a Delphi Study.

Barriers and Facilitators to Staying Smoke-Free after Having a Baby, a Qualitative Study: Women’s Views on Support Needed to Prevent Returning to Smoking Postpartum (2021)
Journal Article

Background: Postpartum return to smoking (PPRS) is a common and important public health problem. Interventions to prevent PPRS have not been shown to be effective. We aimed to qualitatively explore the barriers and facilitators to staying smoke-free... Read More about Barriers and Facilitators to Staying Smoke-Free after Having a Baby, a Qualitative Study: Women’s Views on Support Needed to Prevent Returning to Smoking Postpartum.

Statin treatment and LDL-cholesterol treatment goal attainment among individuals with familial hypercholesterolaemia in primary care (2021)
Journal Article

Objectives: Guidance recommends statin treatment in Familial Hypercholesterolaemia (FH) achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). We assessed statin prescribing rates and LDL-cholesterol treatment goal attainmen... Read More about Statin treatment and LDL-cholesterol treatment goal attainment among individuals with familial hypercholesterolaemia in primary care.

Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection (2021)
Journal Article

Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate hospital admission... Read More about Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.

Earlier detection facilitates skilled responses to deceptive actions (2021)
Journal Article

High-skilled and recreational rugby players were placed in a semi-immersive CAREN Lab environment to examine susceptibility to, and detection of, deception. To achieve this, a broad window of seven occlusion times was used in which participants respo... Read More about Earlier detection facilitates skilled responses to deceptive actions.

Understanding and addressing vaccine hesitancy in the context of COVID-19: development of a digital intervention (2021)
Journal Article

Objectives: Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) was identified in late 2019, spreading to over 200 countries and resulting in almost two million deaths worldwide. The emergence of safe and effective vaccines provides a route out of th... Read More about Understanding and addressing vaccine hesitancy in the context of COVID-19: development of a digital intervention.

Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease (2021)
Journal Article

Background: Globally, about 6% of children are born with a serious birth defect of genetic or partially genetic origin. Carrier screening or testing is one way to identify couples at increased risk of having a child with an autosomal recessive condit... Read More about Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

Comparing the performance of the novel FAMCAT algorithms and established case-finding criteria for familial hypercholesterolaemia in primary care (2021)
Journal Article

Objective Familial hypercholesterolaemia (FH) is a common inherited disorder causing premature coronary heart disease (CHD) and death. We have developed the novel Familial Hypercholesterolaemia Case Ascertainment Tool (FAMCAT 1) case-finding algorith... Read More about Comparing the performance of the novel FAMCAT algorithms and established case-finding criteria for familial hypercholesterolaemia in primary care.

Effectiveness of offering tailored text message, self‐help smoking cessation support to pregnant women who want information on stopping smoking: MiQuit3 randomised controlled trial (RCT) and meta‐analysis (2021)
Journal Article

Aims: To test efficacy of “MiQuit’, a tailored, self-help, text message stop smoking programme for pregnancy, as an adjunct to usual care (UC) for smoking cessation in pregnancy. Design: Multicentre, open, two-arm, parallel-group, superiority rand... Read More about Effectiveness of offering tailored text message, self‐help smoking cessation support to pregnant women who want information on stopping smoking: MiQuit3 randomised controlled trial (RCT) and meta‐analysis.

Strategies for screening for familial hypercholesterolaemia in primary care and other community settings (2021)
Journal Article

Background: Familial hypercholesterolaemia is a common inherited condition that is associated with premature cardiovascular disease. The increased cardiovascular morbidity and mortality, resulting from high levels of cholesterol since birth, can be p... Read More about Strategies for screening for familial hypercholesterolaemia in primary care and other community settings.

Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study (2021)
Journal Article

Background: Oral prednisolone is the mainstay treatment for bullous pemphigoid, an autoimmune blistering skin disorder affecting older people. Treatment with moderate-to-high doses is often initiated in secondary care, but then continued in primary c... Read More about Long-term oral prednisolone exposure in primary care for bullous pemphigoid: population-based study.

Effectiveness of cascade testing strategies in relatives for familial hypercholesterolemia: A systematic review and meta-analysis (2021)
Journal Article

Background and aims: Cascade testing in relatives of index cases is the most cost-effective approach to identifying people with familial hypercholesterolemia (FH); however, it is currently unclear which strategy to contact relatives would be the most... Read More about Effectiveness of cascade testing strategies in relatives for familial hypercholesterolemia: A systematic review and meta-analysis.