All Outputs (56)

Can machine-learning improve cardiovascular risk prediction using routine clinical data (2017)
Journal Article

Background Current approaches to predict cardiovascular risk fail to identify many people who would benefit from preventive treatment, while others receive unnecessary intervention. Machine-learning offers opportunity to improve accuracy by exploiti... Read More about Can machine-learning improve cardiovascular risk prediction using routine clinical data.

Incorporating cancer risk information into general practice: a qualitative study using focus groups with health professionals (2017)
Journal Article

Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial (2017)
Journal Article

Background: Many developed countries have high mortality rates for fire-related deaths in children aged 0–14 years with steep social gradients. Evidence-based interventions to promote fire safety practices exist, but the impact of implementing a rang... Read More about Evaluating implementation of a fire-prevention injury prevention briefing in children's centres: cluster randomised controlled trial.

Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study (2017)
Journal Article

Background: Cycling can improve health and well-being by reducing inactivity. Concern about collision crashes may be a barrier to participation since collision crashes can lead to significant mortality and morbidity. The conspicuity of cyclists may b... Read More about Use of conspicuity aids by cyclists and risk of crashes involving other road users: population based case-control study.

Understanding the implementation and adoption of a technological intervention to improve medication safety in primary care: a realist evaluation (2017)
Journal Article

Background: Monitoring for potentially hazardous prescribing is increasingly important to improve medication safety. Healthcare information technology can be used to achieve this aim, for example by providing access to prescribing data through survei... Read More about Understanding the implementation and adoption of a technological intervention to improve medication safety in primary care: a realist evaluation.

Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial (2017)
Journal Article

Background: Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the ear... Read More about Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial.

Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal (2017)
Journal Article

As part of its single technology appraisal (STA) process, the UK National Institute for Health and Care Excellence (NICE) invited the manufacturer of evolocumab (Amgen) to submit evidence on the clinical and cost effectiveness of evolocumab. The appr... Read More about Evolocumab for treating primary hypercholesterolaemia and mixed dyslipidaemia: an evidence review group perspective of a NICE single technology appraisal.

Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis (2017)
Journal Article

Objective: To determine whether sickle cell carriers (‘sickle cell trait’) have an increased risk of venous thromboembolism (VTE). Design: Cohort study with nested case-control analysis. Setting: General population with data from 609 UK gener... Read More about Venous thromboembolism in adults screened for Sickle Cell Trait: a population based cohort study with nested case-control analysis.

Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England (2017)
Journal Article

Background: Maternal depression is common and associated with several child health outcomes. The impact on childhood injuries is underexplored, with existing studies relying on maternal reporting of injury occurrences. Using population healthcare dat... Read More about Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England.

Psychosocial interventions for supporting women to stop smoking in pregnancy (2017)
Journal Article

Background: Tobacco smoking remains one of the few preventable factors associated with complications in pregnancy, and has serious long-term implications for women and babies. Smoking in pregnancy is decreasing in high-income countries, but is strong... Read More about Psychosocial interventions for supporting women to stop smoking in pregnancy.

Development, validity and reliability testing of the East Midlands Evaluation Tool (EMET) for measuring impacts on trainees’ confidence and competence following end of life care training (2017)
Journal Article

Objectives: To develop, test and validate a versatile questionnaire, the East Midlands Evaluation Tool (EMET), for measuring effects of end of life care training events on trainees’ self-reported confidence and competence. Methods: A paper-based q... Read More about Development, validity and reliability testing of the East Midlands Evaluation Tool (EMET) for measuring impacts on trainees’ confidence and competence following end of life care training.

Understanding the epidemiology of avoidable significant harm in primary care: protocol for a retrospective cross-sectional study (2017)
Journal Article

Introduction: Most patient safety research has focused on specialist-care settings where there is an appreciation of the frequency and causes of medical errors, and the resulting burden of adverse events. There have, however, been few large-scale rob... Read More about Understanding the epidemiology of avoidable significant harm in primary care: protocol for a retrospective cross-sectional study.

An automated software system to promote anticoagulation and reduce stroke risk: cluster-randomized controlled trial (2017)
Journal Article

Background and Purpose: Oral anticoagulants (OAC) substantially reduce risk of stroke in atrial fibrillation, but uptake is suboptimal. Electronic health records enable automated identification of people at risk but not receiving treatment. We inve... Read More about An automated software system to promote anticoagulation and reduce stroke risk: cluster-randomized controlled trial.

New horizons in the understanding of the causes and management of diabetic foot disease: report from the 2017 Diabetes UK Annual Professional Conference Symposium (2017)
Journal Article

Diabetes-related foot disease remains a common problem. For wounds, classic teaching recommends the treatment of any infection, offloading the wound and ensuring a good blood supply, as well as ensuring that the other modifiable risk factors are addr... Read More about New horizons in the understanding of the causes and management of diabetic foot disease: report from the 2017 Diabetes UK Annual Professional Conference Symposium.

Patient safety incidents involving sick children in primary care in England and Wales: a mixed methods analysis (2017)
Journal Article

Background: The UK performs poorly relative to other economically developed countries on numerous indicators of care quality for children. The contribution of iatrogenic harm to these outcomes is unclear. As primary care is the first point of health... Read More about Patient safety incidents involving sick children in primary care in England and Wales: a mixed methods analysis.

Lessons learned from the London Exercise and Pregnant (LEAP) Smokers randomised controlled trial process evaluation: implications for the design of physical activity for smoking cessation interventions during pregnancy (2017)
Journal Article

Background: The challenges of delivering interventions for pregnant smokers have been poorly documented. Also, the process of promoting a physical activity intervention for pregnant smokers has not been previously recorded. This study describes the e... Read More about Lessons learned from the London Exercise and Pregnant (LEAP) Smokers randomised controlled trial process evaluation: implications for the design of physical activity for smoking cessation interventions during pregnancy.