All Outputs (76)

The enigmatic origin of papillomavirus protein domains (2017)
Journal Article
Puustusmaa, M., Kirsip, H., Gaston, K., & Abroi, A. (2017). The enigmatic origin of papillomavirus protein domains. Viruses, 9(9), Article 240. https://doi.org/10.3390/v9090240

Almost a century has passed since the discovery of papillomaviruses. A few decades of research have given a wealth of information on the molecular biology of papillomaviruses. Several excellent studies have been performed looking at the long- and sho... Read More about The enigmatic origin of papillomavirus protein domains.

Rho-GTPase activating protein 18: a biomarker associated with good prognosis in invasive breast cancer (2017)
Journal Article
Aleskandarany, M. A., Sonbul, S. N., Surridge, R., Mukherjee, A., Caldas, C., Diez-Rodriguez, M., Ashankyty, I., Albrahim, K. I., Elmouna, A. M., Aneja, R., Martin, S. G., Ellis, I. O., Green, A. R., & Rakha, E. A. (2017). Rho-GTPase activating protein 18: a biomarker associated with good prognosis in invasive breast cancer. British Journal of Cancer, 117(8), 1176-1184. https://doi.org/10.1038/bjc.2017.261

Background: The prognostic value of lymphovascular invasion (LVI) in breast cancer (BC) has been demonstrated in several independent studies. However, identification of driver molecules for LVI remains a challenging task. Large-scale transcriptomic p... Read More about Rho-GTPase activating protein 18: a biomarker associated with good prognosis in invasive breast cancer.

Differential expression of VEGF-Axxx isoforms is critical for development of pulmonary fibrosis (2017)
Journal Article
Barratt, S. L., Blythe, T., Jarrett, C., Ourradi, K., Shelley-Fraser, G., Day, M. J., Qiu, Y., Harper, S., Maher, T. M., Oltean, S., Hames, T. J., Scotton, C. J., Welsh, G. I., Bates, D. O., & Millar, A. B. (2017). Differential expression of VEGF-Axxx isoforms is critical for development of pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine, 196(4), https://doi.org/10.1164/rccm.201603-0568OC

RATIONALE

Fibrosis after lung injury is related to poor outcome, and idiopathic pulmonary fibrosis (IPF) can be regarded as an exemplar. Vascular endothelial growth factor (VEGF)-A has been implicated in this context, but there are conflicting rep... Read More about Differential expression of VEGF-Axxx isoforms is critical for development of pulmonary fibrosis.

A refined method to study gene dosage changes in-vitro using CRISPR/Cas9 (2017)
Journal Article
Raposo, T., Ebili, H., & Ilyas, M. (in press). A refined method to study gene dosage changes in-vitro using CRISPR/Cas9. Journal of Clinical Pathology, 71(3), https://doi.org/10.1136/jclinpath-2017-204558

Aims: Gene dosage can have a major impact on cell biology although, hitherto, is has been difficult to study using in-vitro models. We sought to refine and accelerate the development of “gene dosage” models through using CRISPR/Cas9 (a gene-editing t... Read More about A refined method to study gene dosage changes in-vitro using CRISPR/Cas9.

Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells (2017)
Journal Article
Alharbi, R. A., Pandha, H. S., Simpson, G. R., Pettengell, R., Poterlowicz, K., Thompson, A., Harrington, K., El-Tanani, M., & Morgan, R. (2017). Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells. Oncotarget, 8(52), https://doi.org/10.18632/oncotarget.20023

The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic cell death in a range of... Read More about Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells.

Pharmacovigilance in hospice/palliative care: net effect of haloperidol for nausea or vomiting (2017)
Journal Article
Digges, M., Hussein, A., Wilcock, A., Crawford, G. B., Boland, J. W., Agar, M. R., Sinnarajah, A., Currow, D. C., & Johnson, M. J. (2018). Pharmacovigilance in hospice/palliative care: net effect of haloperidol for nausea or vomiting. Journal of Palliative Medicine, 21(1), 37-43. https://doi.org/10.1089/jpm.2017.0159

Background: Haloperidol is widely prescribed as an antiemetic in patients receiving palliative care, but there is limited evidence to support and refine its use.

Objective: To explore the immediate and short-term net clinical effects of haloperido... Read More about Pharmacovigilance in hospice/palliative care: net effect of haloperidol for nausea or vomiting.

HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues (2017)
Journal Article
Qaiser, T., Mukherjee, A., Reddy Pb, C., Munugoti, S. D., Tallam, V., Pitkäaho, T., Lehtimäki, T., Naughton, T., Berseth, M., Pedraza, A., Mukundan, R., Smith, M., Bhalerao, A., Rodner, E., Simon, M., Denzler, J., Huang, C.-H., Bueno, G., Snead, D., Ellis, I. O., …Rajpoot, N. (2018). HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues. Histopathology, 72(2), 227-238. https://doi.org/10.1111/his.13333

Aims

Evaluating expression of the Human epidermal growth factor receptor 2 (Her2) by visual examination of immunohistochemistry (IHC) on invasive breast cancer (BCa) is a key part of the diagnostic assessment of BCa due to its recognised importanc... Read More about HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues.

Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations (2017)
Journal Article
El Ansari, R., McIntyre, A., Craze, M. L., Ellis, I. O., Rakha, E. A., & Green, A. R. (in press). Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations. Histopathology, https://doi.org/10.1111/his.13334

Cancer cells must alter their metabolism in order to satisfy the demands of necessary energy and cellular building blocks. These metabolic alterations are mediated by many oncogenic changes that affect cellular signalling pathways, which result in su... Read More about Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations.

Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms: A Unique Invasive Tumor With Indolent Behavior (2017)
Journal Article
Foschini, M. P., Asioli, S., Foreid, S., Cserni, G., Ellis, I. O., Eusebi, V., & Rosai, J. (2017). Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms: A Unique Invasive Tumor With Indolent Behavior. American Journal of Surgical Pathology, 41(7), 887-895. https://doi.org/10.1097/pas.0000000000000853

Thirteen cases of invasive solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (BPTC) are reported here. Some cases had long-term follow-up. BPTC is a special type of primary breast neoplasm showing a tri... Read More about Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms: A Unique Invasive Tumor With Indolent Behavior.

Current trials to reduce surgical intervention in ductal carcinoma in situ of the breast: critical review (2017)
Journal Article
Toss, M., Miligy, I., Thompson, A., Khout, H., Green, A., Ellis, I., & Rakha, E. (2017). Current trials to reduce surgical intervention in ductal carcinoma in situ of the breast: critical review. Breast, 35, 151-156. https://doi.org/10.1016/j.breast.2017.07.012

The high proportion of ductal carcinoma in situ (DCIS) presented in mammographic screening and the relatively low risk of progression to invasive disease have raised questions related to overtreatment. Following a review of current DCIS management pr... Read More about Current trials to reduce surgical intervention in ductal carcinoma in situ of the breast: critical review.

MicroRNA regulation of glycolytic metabolism in glioblastoma multiforme (2017)
Journal Article
Alfardus, H., McIntyre, A., & Smith, S. J. (2017). MicroRNA regulation of glycolytic metabolism in glioblastoma multiforme. BioMed Research International, 2017, https://doi.org/10.1155/2017/9157370

Glioblastoma multiforme (GBM) is the most aggressive and common malignant brain and central nervous system tumour. A well-known hallmark of GMB, and many other tumours, is aerobic glycolysis. microRNAs (miRNAs) are a class of short non-protein coding... Read More about MicroRNA regulation of glycolytic metabolism in glioblastoma multiforme.

Novel immunohistochemistry-based signatures to predict metastatic site of triple-negative breast cancers (2017)
Journal Article
Klimov, S., Rida, P. C., Aleskandarany, M. A., Green, A. R., Ellis, I. O., Janssen, E. A., Rakha, E. A., & Aneja, R. (2017). Novel immunohistochemistry-based signatures to predict metastatic site of triple-negative breast cancers. British Journal of Cancer, 117(6), 826-834. https://doi.org/10.1038/bjc.2017.224

Background: Although distant metastasis (DM) in breast cancer (BC) is the most lethal form of recurrence and the most common
underlying cause of cancer related deaths, the outcome following the development of DM is related to the site of metastasis.... Read More about Novel immunohistochemistry-based signatures to predict metastatic site of triple-negative breast cancers.

TLDc proteins: new players in the oxidative stress response and neurological disease (2017)
Journal Article
Finelli, M. J., & Oliver, P. L. (2017). TLDc proteins: new players in the oxidative stress response and neurological disease. Mammalian Genome, 28(9-10), 395-406. https://doi.org/10.1007/s00335-017-9706-7

Oxidative stress (OS) arises from an imbalance in the cellular redox state, which can lead to intracellular damage and ultimately cell death. OS occurs as a result of normal ageing, but it is also implicated as a common etiological factor in neurolog... Read More about TLDc proteins: new players in the oxidative stress response and neurological disease.

Immunostaining for DNA modifications: computational analysis of confocal images (2017)
Journal Article
Ramsawhook, A., Lewis, L. C., Eleftheriou, M., Abakir, A., Durczak, P. M., Markus, R., Rajini, S., Hannan, N. R., Coyle, B., & Ruzov, A. (2017). Immunostaining for DNA modifications: computational analysis of confocal images. Journal of Visualized Experiments, Article e56318. https://doi.org/10.3791/56318

For several decades, 5-methylcytosine (5mC) has been thought to be the only DNA modification with a functional significance in metazoans. The discovery of enzymatic oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carb... Read More about Immunostaining for DNA modifications: computational analysis of confocal images.

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids (2017)
Journal Article
Sampaziotis, F., Justin, A. W., Tysoe, O. C., Sawiak, S., Godfrey, E. M., Upponi, S. S., Gieseck, R. L., de Brito, M. C., Berntsen, N. L., Gómez-Vázquez, M. J., Ortmann, D., Yiangou, L., Ross, A., Bargehr, J., Bertero, A., Zonneveld, M. C., Pedersen, M. T., Pawlowski, M., Valestrand, L., Madrigal, P., …Vallier, L. (2017). Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine, 23(8), 954-963. https://doi.org/10.1038/nm.4360

© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. The treatment of common bile duct (CBD) disorders, such as biliary atresia or ischemic strictures, is restricted by the lack of biliary tissue from healthy donors suitable for... Read More about Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.

Expression of a SOX1 overlapping transcript in neural differentiation and cancer models (2017)
Journal Article
Azaz, A., Strohbuecker, S., Tufarelli, C., & Sottile, V. (2017). Expression of a SOX1 overlapping transcript in neural differentiation and cancer models. Cellular and Molecular Life Sciences, 74(22),

SOX1 is a member of the SOXB1 subgroup of transcription factors involved in early embryogenesis, CNS development and maintenance of neural stem cells. The structure and regulation of the human SOX1 locus has been less studied than that of SOX2, anoth... Read More about Expression of a SOX1 overlapping transcript in neural differentiation and cancer models.

VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney (2017)
Journal Article
Stevens, M., Neal, C. R., Salmon, A. H., Bates, D. O., Harper, S. J., & Oltean, S. (2017). VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney. Journal of Physiology, 595(19), 6281-6298. https://doi.org/10.1113/jp274481

Chronic kidney disease (CKD) is strongly associated with a decrease in the expression of VEGF-A. However, little is known about the contribution of VEGF-A splice isoforms to kidney physiology and pathology. Previous studies suggest that the splice is... Read More about VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney.

Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy (2017)
Journal Article
Hay, J. F., Lappin, K., Liberante, F., Kettyle, L. M., Matchett, K. B., Thompson, A., & Mills, K. I. (2017). Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy. Oncotarget, 8(40), https://doi.org/10.18632/oncotarget.18910

Several histone deacetylase inhibitors including Vorinostat have received FDA approval for the treatment of haematological malignancies. However, data from these trials indicate that Vorinostat has limited efficacy as a monotherapy, prompting the nee... Read More about Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy.

Multicomponent analysis of the tumour microenvironment reveals low CD8 T cell number, low stromal caveolin-1 and high tenascin-C and their combination as significant prognostic markers in non-small cell lung cancer (2017)
Journal Article
Onion, D., Isherwood, M., Shridhar, N., Xenophontos, M., Craze, M. L., Day, L. J., Gárcia-Marquez, M. A., Pineda, R. G., Reece-Smith, A. M., Saunders, J. H., Duffy, J. P., Argent, R. H., & Grabowska, A. M. (2018). Multicomponent analysis of the tumour microenvironment reveals low CD8 T cell number, low stromal caveolin-1 and high tenascin-C and their combination as significant prognostic markers in non-small cell lung cancer. Oncotarget, 9(2), 1760-1771. https://doi.org/10.18632/oncotarget.18880

The complex interplay of the tumour microenvironment (TME) and its role in disease progression and response to therapy is poorly understood. The majority of studies to date focus on individual components or molecules within the TME and so lack the po... Read More about Multicomponent analysis of the tumour microenvironment reveals low CD8 T cell number, low stromal caveolin-1 and high tenascin-C and their combination as significant prognostic markers in non-small cell lung cancer.

The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1 (2017)
Journal Article
Pruszko, M., Milano, E., Forcato, M., Donzelli, S., Ganci, F., Di Agostino, S., De Panfilis, S., Fazi, F., Bates, D. O., Bicciato, S., Zylicz, M., Żylicz, A., Blandino, G., & Fontemaggi, G. (in press). The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1. EMBO Reports, Article e201643370. https://doi.org/10.15252/embr.201643370

The abundant, nuclear-retained, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been associated with a poorly differentiated and aggressive phenotype of mammary carcinomas. This long non-coding RNA (lncRNA) localizes to nuclear... Read More about The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1.