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Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms: A Unique Invasive Tumor With Indolent Behavior

Foschini, Maria P.; Asioli, Sofia; Foreid, Susan; Cserni, Gabor; Ellis, Ian O.; Eusebi, Vincenzo; Rosai, Juan

Authors

Maria P. Foschini

Sofia Asioli

Susan Foreid

Gabor Cserni

Vincenzo Eusebi

Juan Rosai



Abstract

Thirteen cases of invasive solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (BPTC) are reported here. Some cases had long-term follow-up. BPTC is a special type of primary breast neoplasm showing a triple-negative profile but low aggressive potential. Knowledge on BPTC is still scanty; therefore, the aim of the present paper was to report on the features of an additional 13 cases. All the patients were female individuals, and the mean age at presentation was 62.6 years; nodule sizes ranged from 0.6 to 2.5 cm (average, 1.6 cm). All the cases were characterized on histology by papillary, follicular as well as solid structures. The cells were columnar, eosinophilic mostly with granular cytoplasms, rich in mitochondria, with the features of oncocytes in no fewer than 7 cases. Estrogen and progesterone receptors as well as HER2 were consistently negative. The Ki67 proliferative index was low. Markers consistent with thyroid origin, such as TTF1 and thyroglobulin, were negative. Five cases stained for mammoglobin and GATA 3 were positive. All cases proved to be invasive and 2 cases each experienced metastases to 1 lymph node (axillary and intramammary). One case of the latter had a local recurrence. Nevertheless, all the patients are alive, free of disease 24 to 132 months after surgery, of which 8 are without further treatment The present series confirms that BPTC is a primary breast tumor of low malignant potential.

Journal Article Type Article
Publication Date 2017-07
Journal The American Journal of Surgical Pathology
Print ISSN 0147-5185
Electronic ISSN 1532-0979
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 41
Issue 7
Pages 887-895
APA6 Citation Foschini, M. P., Asioli, S., Foreid, S., Cserni, G., Ellis, I. O., Eusebi, V., & Rosai, J. (2017). Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms: A Unique Invasive Tumor With Indolent Behavior. American Journal of Surgical Pathology, 41(7), 887-895. doi:10.1097/pas.0000000000000853
DOI https://doi.org/10.1097/pas.0000000000000853
Publisher URL https://journals.lww.com/ajsp/Abstract/2017/07000/Solid_Papillary_Breast_Carcinomas_Resembling_the.3.aspx
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