All Outputs (3)

The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely turned system for modulating available E7 and E2 proteins (2009)
Journal Article
Smal, C., Wetzler, D. E., Dantur, K. I., Chemes, L. B., Garcia-Alai, M. M., Dellarole, M., …de Prat Gay, G. (2009). The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely turned system for modulating available E7 and E2 proteins. Biochemistry, 48(50), 11939-11949. https://doi.org/10.1021/bi901415k

Transcription of the human papillomavirus E7 oncoprotein is negatively controlled by the viral E2 protein, and loss of this repression leads to irreversible transformation and carcinogenesis. Here we show that interaction of the HPV16 E7 protein with... Read More about The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely turned system for modulating available E7 and E2 proteins.

CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding (2009)
Journal Article
Soufi, A., Noy, P., Buckle, M., Sawasdichai, A., Gaston, K., & Jayaraman, P. (2009). CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding. Nucleic Acids Research, 37(10), 3288-3300. doi:10.1093/nar/gkp197

The proline-rich homeodomain protein (PRH/Hex) regulates transcription by binding to specific DNA sequences and regulates mRNA transport by binding to translation initiation factor eIF4E. Protein kinase CK2 plays multiple roles in the regulation of g... Read More about CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding.

The regulation of cell proliferation by the papillomavirus early proteins (2009)
Journal Article
Abdul Hamid, N., Brown, C., & Gaston, K. (2009). The regulation of cell proliferation by the papillomavirus early proteins. Cellular and Molecular Life Sciences, 66(10), 1700-1717. doi:10.1007/s00018-009-8631-7

The human papillomavirus (HPV) E6 and E7 oncogenes have direct effects on host cell proliferation. The viral E2 protein regulates transcription of E6 and E7 and thereby has an indirect effect on cell proliferation. In HPV-induced tumours, misappropri... Read More about The regulation of cell proliferation by the papillomavirus early proteins.