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The regulation of cell proliferation by the papillomavirus early proteins

Abdul Hamid, N.; Brown, C.; Gaston, K.

Authors

N. Abdul Hamid

C. Brown

K. Gaston



Abstract

The human papillomavirus (HPV) E6 and E7 oncogenes have direct effects on host cell proliferation. The viral E2 protein regulates transcription of E6 and E7 and thereby has an indirect effect on cell proliferation. In HPV-induced tumours, misappropriate random integration of the viral genome into the host chromosome often leads to disruption of the E2 gene and the loss of E2 expression. This results in cessation of the virus life cycle and the deregulation of E6 and E7 and is an important step in tumourigenesis. However, prior to these integration events, E2 can interact directly with the E6 and E7 proteins and modulate their activities. E2 also interacts with a variety of host proteins, including the p53 tumour suppressor protein. Here we outline evidence that suggests a role for E2 in the regulation of cell proliferation, and we discuss the importance of this regulation in viral infection and cervical tumourigenesis.

Journal Article Type Article
Publication Date 2009-05
Journal Cellular and Molecular Life Sciences
Print ISSN 1420-682X
Publisher BMC
Peer Reviewed Peer Reviewed
Volume 66
Issue 10
Pages 1700-1717
APA6 Citation Abdul Hamid, N., Brown, C., & Gaston, K. (2009). The regulation of cell proliferation by the papillomavirus early proteins. Cellular and Molecular Life Sciences, 66(10), 1700-1717. doi:10.1007/s00018-009-8631-7
DOI https://doi.org/10.1007/s00018-009-8631-7
Keywords Papillomavirus; cell proliferation; oncogene; transcription; cancer
Publisher URL https://link.springer.com/article/10.1007%2Fs00018-009-8631-7


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