All Outputs (4)

AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development (2009)
Journal Article

Deregulation of the insulin-like growth factor 1 (IGF-1) signaling pathway is a recurrent finding in mouse models and human patients with cerebellar ataxia and thus represents a common pathological cascade in neuronal cell death that may be targeted... Read More about AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development.

The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely turned system for modulating available E7 and E2 proteins (2009)
Journal Article

Transcription of the human papillomavirus E7 oncoprotein is negatively controlled by the viral E2 protein, and loss of this repression leads to irreversible transformation and carcinogenesis. Here we show that interaction of the HPV16 E7 protein with... Read More about The human papillomavirus E7-E2 interaction mechanism in vitro reveals a finely turned system for modulating available E7 and E2 proteins.

CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding (2009)
Journal Article

The proline-rich homeodomain protein (PRH/Hex) regulates transcription by binding to specific DNA sequences and regulates mRNA transport by binding to translation initiation factor eIF4E. Protein kinase CK2 plays multiple roles in the regulation of g... Read More about CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding.

The regulation of cell proliferation by the papillomavirus early proteins (2009)
Journal Article

The human papillomavirus (HPV) E6 and E7 oncogenes have direct effects on host cell proliferation. The viral E2 protein regulates transcription of E6 and E7 and thereby has an indirect effect on cell proliferation. In HPV-induced tumours, misappropri... Read More about The regulation of cell proliferation by the papillomavirus early proteins.