All Outputs (3)

Cten promotes epithelial-mesenchymal transition through post-transcriptional stabilization of Snail (2017)
Journal Article
Thorpe, H., Asiri, A., Akhlaq, M., & Ilyas, M. (in press). Cten promotes epithelial-mesenchymal transition through post-transcriptional stabilization of Snail. Molecular Carcinogenesis, 56(12), https://doi.org/10.1002/mc.22704

Cten promotes cell migration however the knowledge of underlying signalling pathways is sparse. We have shown that Cten downregulates E-cadherin, a feature of epithelial to mesenchymal transition (EMT). This prompted us to investigate whether Cten fu... Read More about Cten promotes epithelial-mesenchymal transition through post-transcriptional stabilization of Snail.

A refined method to study gene dosage changes in-vitro using CRISPR/Cas9 (2017)
Journal Article
Raposo, T., Ebili, H., & Ilyas, M. (in press). A refined method to study gene dosage changes in-vitro using CRISPR/Cas9. Journal of Clinical Pathology, 71(3), https://doi.org/10.1136/jclinpath-2017-204558

Aims: Gene dosage can have a major impact on cell biology although, hitherto, is has been difficult to study using in-vitro models. We sought to refine and accelerate the development of “gene dosage” models through using CRISPR/Cas9 (a gene-editing t... Read More about A refined method to study gene dosage changes in-vitro using CRISPR/Cas9.

HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues (2017)
Journal Article
Qaiser, T., Mukherjee, A., Reddy Pb, C., Munugoti, S. D., Tallam, V., Pitkäaho, T., …Rajpoot, N. (2018). HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues. Histopathology, 72(2), 227-238. https://doi.org/10.1111/his.13333

Aims Evaluating expression of the Human epidermal growth factor receptor 2 (Her2) by visual examination of immunohistochemistry (IHC) on invasive breast cancer (BCa) is a key part of the diagnostic assessment of BCa due to its recognised importanc... Read More about HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues.