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Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer (2018)
Journal Article
Kurozumi, S., Joseph, C., Sonbul, S., Aleskandarany, M. A., Pigera, M., Alsaleem, M., …Rakha, E. A. (2018). Clinicopathological and prognostic significance of Ras association and pleckstrin homology domains 1 (RAPH1) in breast cancer. Breast Cancer Research and Treatment, 172(1), 61–68. doi:10.1007/s10549-018-4891-y

BACKGROUND: Ras association and pleckstrin homology domains 1 (RAPH1) is involved in cytoskeleton regulation and re-epithelialisation in invasive carcinoma and therefore may play a key role in carcinogenesis and metastasis. We herein investigated the... Read More

A randomised controlled trial of the compuLsive Exercise Activity TheraPy (LEAP): a new approach to compulsive exercise in anorexia nervosa (2018)
Journal Article
Hay, P., Touyz, S., Arcelus, J., Pike, K., Attia, E., Crosby, R. D., …Meyer, C. (2018). A randomised controlled trial of the compuLsive Exercise Activity TheraPy (LEAP): a new approach to compulsive exercise in anorexia nervosa. International Journal of Eating Disorders, 51(8), 999-1004. doi:10.1002/eat.22920

Objective: To compare the efficacy of the compuLsive Exercise Activity theraPy (LEAP) programme integrated with manualised cognitive behavioural therapy for anorexia nervosa (CBT-AN) compared to CBT-AN alone. Method: Seventy-eight adults were rando... Read More

Refinement and validation of the Social Participation Restrictions Questionnaire: an application of Rasch analysis and traditional psychometric analysis techniques (2018)
Journal Article
Eithne, H., David, M., Johanna, B., & Melanie, F. (in press). Refinement and validation of the Social Participation Restrictions Questionnaire: an application of Rasch analysis and traditional psychometric analysis techniques. Ear and Hearing, doi:10.1097/AUD.0000000000000618

Objectives: The primary aim of this research was to refine and validate the Social Participation Restrictions Questionnaire (SPaRQ). The SPaRQ is a hearing-specific, patient-reported outcome measure that was originally developed through consultation... Read More

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas (2018)
Journal Article
Geyer, F. C., Li, A., Papanastasiou, A. D., Smith, A., Selenica, P., Burke, K. A., …Reis-Filho, J. S. (2018). Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nature Communications, 9, doi:10.1038/s41467-018-04128-5. ISSN 2041-1723

Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial-myoepithelial differentiation, of which a subset will progress to invasive or metastatic cancer. We sought to define the genomic landscape of adenomyoepitheliomas. Massivel... Read More

Development of a multimedia educational programme for first-time hearing aid users: a participatory design (2018)
Journal Article
Ferguson, M. A., Leighton, P., Brandreth, M., & Wharrad, H. (in press). Development of a multimedia educational programme for first-time hearing aid users: a participatory design. International Journal of Audiology, doi:10.1080/14992027.2018.1457803

Objective: To develop content for a series of interactive video tutorials (or reusable learning objects, RLOs) for first-time adult hearing aid users, to enhance knowledge of hearing aids and communication. Design: RLO content was based on an elect... Read More

The concept of compassion within UK media generated discourse: a corpus informed analysis (2018)
Journal Article
Bond, C., Stacey, G., Field-Richards, S., Callaghan, P., Keeley, P., Lymn, J., …Spiby, H. (2018). The concept of compassion within UK media generated discourse: a corpus informed analysis. Journal of Clinical Nursing, 27(15-16), 3081-3090. doi:10.1111/jocn.14496

Aims and objectives: To examine how the concept of compassion is socially constructed within UK discourse, in response to recommendations that aspiring nurses gain care experience prior to entering nurse education. Background: Following a report of... Read More

Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial (2018)
Journal Article
Rowlands, M., Walt, G. V. D., Bradley, J., Mannings, A., Armstrong, S., Bedforth, N. M., …Sahota, O. (2018). Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial. BMJ Open, 8(4), doi:10.1136/bmjopen-2017-019650

Objective Fractured neck of femur is a severely painful condition with significant mortality and morbidity. We investigated whether early and continuous use of femoral nerve block can improve pain on movement and mobility after surgery in older p... Read More

Oral ketamine vs placebo in patients with cancer-related neuropathic pain (2018)
Journal Article
Fallon, M. T., Wilcock, A., Kelly, C. A., Paul, J., Lewsley, L., Norrie, J., & Laird, B. J. A. (2018). Oral ketamine vs placebo in patients with cancer-related neuropathic pain. JAMA Oncology, 4(6), 870-872. doi:10.1001/jamaoncol.2018.0131

Ketamine hydrochloride is used as an adjuvant treatment for cancer-related neuropathic pain, but evidence of its effectiveness is limited.1 Findings of a large trial investigating the use of ketamine for general cancer pain were negative, but the pop... Read More

Characterisation of insulin analogues therapeutically available to patients (2018)
Journal Article
Adams, G. G., Meal, A., Morgan, P. S., Alzahrani, Q. E., Zobel, H., Lithgo, R., …Chayen, N. (2018). Characterisation of insulin analogues therapeutically available to patients. PLoS ONE, 13(3), doi:10.1371/journal.pone.0195010

The structure and function of clinical dosage insulin and its analogues were assessed. This included ‘native insulins’ (human recombinant, bovine, porcine), ‘fast-acting analogues’ (aspart, glulisine, lispro) and ‘slow-acting analogues’ (glargine, de... Read More

Hip precautions after hip operation (HippityHop): protocol for a before and after study evaluating hip precautions following total hip replacement (2018)
Journal Article
Lightfoot, C., Sehat, K., Drury, G., Brewin, C., Coole, C., & Drummond, A. E. (in press). Hip precautions after hip operation (HippityHop): protocol for a before and after study evaluating hip precautions following total hip replacement. British Journal of Occupational Therapy, doi:10.1177/0308022618757183

Introduction Hip precautions are routinely used despite inconclusive evidence that they reduce dislocations, and concern that they impede activities of daily living. HippityHop compares a change in practice locally from implementing routine hip prec... Read More

Levels of depression in transgender people and its predictors: results of a large matched control study with transgender people accessing clinical services (2018)
Journal Article
Witcomb, G. L., Bouman, W. P., Claes, L., Brewin, N., Crawford, J. R., & Arcelus, J. (2018). Levels of depression in transgender people and its predictors: results of a large matched control study with transgender people accessing clinical services. Journal of Affective Disorders, 235, doi:10.1016/j.jad.2018.02.051

Background: Depression is a serious disorder which significantly impacts wellbeing and quality of life. Studies exploring mental wellbeing in the transgender population are mostly limited by small, non-homogenous samples and lack of matched controls.... Read More

Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial (2018)
Journal Article
das Nair, R., Mhizha-Murira, J. R., Anderson, P., Carpenter, H., Clarke, S., Groves, S., …Lincoln, N. B. (2018). Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomised controlled trial. Clinical Rehabilitation, 32(6), 777-789. doi:10.1177/0269215518755426

Objective: To determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty. Design: Multi-centre, mixed-methods feasibi... Read More

Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease (2018)
Journal Article
Sargeant, J. A., Bawden, S., Aithal, G. P., Simpson, E. J., Macdonald, I. A., Turner, M. C., …King, J. A. (2018). Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease. European Journal of Applied Physiology, 118(4), doi:10.1007/s00421-018-3818-y

Purpose: This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral... Read More

Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (TH1, TH2) to immune-mediated tumour c (2018)
Journal Article
Kaewkangsadan, V., Verma, C., Eremin, J. M., Cowley, G. P., Ilyas, M., & Eremin, O. (2018). Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (TH1, TH2) to immune-mediated tumour cell death induced by NAC. BMC Cancer, 18, doi:10.1186/s12885-018-4044-z

Background The tumour microenvironment consists of malignant cells, stroma and immune cells. In women with large and locally advanced breast cancers (LLABCs) undergoing neoadjuvant chemotherapy (NAC), tumour-infiltrating lymphocytes (TILs), variou... Read More

Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility (2018)
Journal Article
Cooper, D. J., Scammell, B. E., Batt, M. E., & Palmer, D. (in press). Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility. BMC Medical Research Methodology, 18(1), doi:10.1186/s12874-017-0464-8

Background: The impracticalities and comparative expense of carrying out a clinical assessment is an obstacle in many large epidemiological studies. The purpose of this study was to develop and validate a series of electronic self-reported line drawi... Read More

Therapeutic benefit for late, but not early, passage mesenchymal stem cells on pain behaviour in an animal model of osteoarthritis (2017)
Journal Article
Chapman, V., Markides, H., Sagar, D. R., Xu, L., Burston, J. J., Mapp, P., …El Haj, A. J. (2017). Therapeutic benefit for late, but not early, passage mesenchymal stem cells on pain behaviour in an animal model of osteoarthritis. Stem Cells International, 2017, doi:10.1155/2017/2905104

Background: Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi... Read More

UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery (2017)
Journal Article
Abbas, Z. S., Latif, M. L., Dovlatova, N., Fox, S. C., Heptinstall, S., Dunn, W. R., & Ralevic, V. (2018). UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascular Pharmacology, 103-105, doi:10.1016/j.vph.2017.12.063

Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y14 receptor is a Gi/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides. In thi... Read More

Results of the FIRST STEPS study: a randomised controlled trial and economic evaluation of the Group Family Nurse Partnership (gFNP) programme compared to routine care in improving outcomes for high-risk mothers and their children and preventing abuse (2017)
Journal Article
Barnes, J., Stuart, J., Allen, E., Petrou, S., Sturgess, J., Barlow, J., …Elbourne, D. (2017). Results of the FIRST STEPS study: a randomised controlled trial and economic evaluation of the Group Family Nurse Partnership (gFNP) programme compared to routine care in improving outcomes for high-risk mothers and their children and preventing abuse. Public Health Research, 5(9), doi:10.3310/phr05090

Background: Family Nurse Partnership (FNP) is a home-based nurse home-visiting programme to support vulnerable parents. Group FNP (gFNP) has similar aims and materials and was demonstrated to be feasible in implementation evaluations. Objectives: To... Read More

Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma (2017)
Journal Article
Fateen, W., Khan, F., O’Neill, R., James, M., Ryder, S., & Aithal, G. (2017). Healthcare costs of transarterial chemoembolization in the treatment of hepatocellular carcinoma. Journal of Hepatocellular Carcinoma, 2017(4), doi:10.2147/JHC.S144068

Background: A meta-analysis comparing drug-eluting beads transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (cTACE) has recently been published. On balance, no significant differences were found in terms of o... Read More