All Outputs (1131)

MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial (2022)
Journal Article
Rodriguez, D., Calmon, R., Aliaga, E. S., Warren, D., Warmuth-Metz, M., Jones, C., …Jaspan, T. (2022). MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial. Radiology, 304(1), 174-182. https://doi.org/10.1148/radiol.211464

Background Diffuse midline gliomas (DMG) are characterized by a high incidence of H3 K27 mutations and poorer outcome. The HERBY trial has provided one of the largest cohorts of pediatric DMGs with available radiologic, histologic-genotypic, and surv... Read More about MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial.

Amide proton transfer imaging in stroke (2022)
Journal Article
Heo, H. Y., Tee, Y. K., Harston, G., Leigh, R., & Chappell, M. A. (2022). Amide proton transfer imaging in stroke. NMR in Biomedicine, Article e4734. https://doi.org/10.1002/nbm.4734

Amide proton transfer (APT) imaging, a variant of chemical exchange saturation transfer MRI, has shown promise in detecting ischemic tissue acidosis following impaired aerobic metabolism in animal models and in human stroke patients due to the sensit... Read More about Amide proton transfer imaging in stroke.

Determining the Effects of Transcranial Direct Current Stimulation on Tinnitus, Depression, and Anxiety: A Systematic Review (2022)
Journal Article
Labree, B., Hoare, D. J., Gascoyne, L. E., Scutt, P., Del Giovane, C., & Sereda, M. (2022). Determining the Effects of Transcranial Direct Current Stimulation on Tinnitus, Depression, and Anxiety: A Systematic Review. Brain Sciences, 12(4), Article 484. https://doi.org/10.3390/brainsci12040484

Background: Tinnitus is the awareness of a sound in the absence of an external source. It affects around 10–15% of people, a significant proportion of whom also experience symptoms such as depression or anxiety that negatively affect their quality of... Read More about Determining the Effects of Transcranial Direct Current Stimulation on Tinnitus, Depression, and Anxiety: A Systematic Review.

Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research (2022)
Journal Article
Senekowitsch, S., Schick, P., Abrahamsson, B., Augustijns, P., Gießmann, T., Lennernäs, H., …Koziolek, M. (2022). Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research. Pharmaceutics, 14(4), Article 801. https://doi.org/10.3390/pharmaceutics14040801

Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Un... Read More about Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research.

Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic (2022)
Journal Article
Ali, W., Elsahn, A., Ting, D. S. J., Dua, H. S., & Mohammed, I. (2022). Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic. Antibiotics, 11(4), Article 475. https://doi.org/10.3390/antibiotics11040475

One of the greatest challenges facing the medical community today is the ever-increasing trajectory of antimicrobial resistance (AMR), which is being compounded by the decrease in our antimicrobial armamentarium. From their initial discovery to the c... Read More about Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic.

Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments (2022)
Journal Article
Brosnan, M. B., Shalev, N., Ramduny, J., Sotiropoulos, S. N., & Chechlacz, M. (2022). Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments. Brain Communications, 4(2), Article fcac080. https://doi.org/10.1093/braincomms/fcac080

Exposure to enriched environments throughout a lifetime, providing so-called reserve, protects against cognitive decline in later years. It has been hypothesized that high levels of alertness necessitated by enriched environments might strengthen the... Read More about Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments.

The association between inadequate sleep and accelerated brain ageing (2022)
Journal Article
Ramduny, J., Bastiani, M., Huedepohl, R., Sotiropoulos, S. N., & Chechlacz, M. (2022). The association between inadequate sleep and accelerated brain ageing. Neurobiology of Aging, 114, 1-14. https://doi.org/10.1016/j.neurobiolaging.2022.02.005

Numerous studies indicate large heterogeneity in brain ageing, which can be attributed to modifiable lifestyle factors, including sleep. Inadequate sleep has been previously linked to gray (GM) and white (WM) matter changes. However, the reported fin... Read More about The association between inadequate sleep and accelerated brain ageing.

Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial (2022)
Journal Article
Pszczolkowski, S., Sprigg, N., Woodhouse, L. J., Gallagher, R., Swienton, D., Law, Z. K., …Dineen, R. A. (2022). Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial. JAMA Neurology, 79(5), 468-477. https://doi.org/10.1001/jamaneurol.2022.0217

Importance: Hyperintense foci on diffusion-weighted imaging (DWI) that are spatially remote from the acute hematoma occur in 20% of people with acute spontaneous intracerebral hemorrhage (ICH). Tranexamic acid, a hemostatic agent that is under invest... Read More about Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial.

Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study (2022)
Journal Article
Weaver, L., Das, A., Saffaran, S., Yehya, N., Chikhani, M., Scott, T. E., …Bates, D. G. (2022). Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study. British Journal of Anaesthesia, https://doi.org/10.1016/j.bja.2022.02.037

Background: Optimal respiratory support in early COVID-19 pneumonia is controversial and remains unclear. Using computational modelling, we examined whether lung injury might be exacerbated in early COVID-19 by assessing the impact of conventional ox... Read More about Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study.

Consensus Definition of Misophonia: A Delphi Study (2022)
Journal Article
Swedo, S., Baguley, D. M., Denys, D., Dixon, L. J., Erfanian, M., Fioretti, A., …Raver, S. M. (2022). Consensus Definition of Misophonia: A Delphi Study. Frontiers in Neuroscience, 16, Article 841816. https://doi.org/10.3389/fnins.2022.841816

Misophonia is a disorder of decreased tolerance to specific sounds or their associated stimuli that has been characterized using different language and methodologies. The absence of a common understanding or foundational definition of misophonia hind... Read More about Consensus Definition of Misophonia: A Delphi Study.

Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection (2022)
Journal Article
Dhillon, P. S., Butt, W., Podlasek, A., McConachie, N., Lenthall, R., Nair, S., …England, T. J. (2023). Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection. Journal of NeuroInterventional Surgery, 15(4), 336-342. https://doi.org/10.1136/neurintsurg-2021-018564

Background: The effectiveness and safety of endovascular thrombectomy (EVT) in the late window (6-24 hours) for acute ischemic stroke (AIS) patients selected without advanced imaging is undetermined. We aimed to assess clinical outcomes and the relat... Read More about Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection.

Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis (2022)
Journal Article
Althubeati, S., Avery, A., Tench, C., Lobo, D. N., Salter, A., & Eldeghaidy, S. (2022). Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis. Neuroscience and Biobehavioral Reviews, 136, Article 104603. https://doi.org/10.1016/j.neubiorev.2022.104603

Understanding how neurohormonal gut-brain signaling regulates appetite and satiety is vital for the development of therapies for obesity and altered eating behavior. However, reported brain areas associated with appetite or satiety regulators show in... Read More about Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis.

Experiences of receiving a diagnosis of multiple sclerosis: a meta-synthesis of qualitative studies (2022)
Journal Article
Topcu, G., Mhizha-Murira, J. R., Griffiths, H., Bale, C., Drummond, A., Fitzsimmons, D., …das Nair, R. (2023). Experiences of receiving a diagnosis of multiple sclerosis: a meta-synthesis of qualitative studies. Disability and Rehabilitation, 45(5), 772-783. https://doi.org/10.1080/09638288.2022.2046187

Purpose: This meta-synthesis aimed to synthesise qualitative evidence on experiences of people with Multiple Sclerosis (MS) in receiving a diagnosis, to derive a conceptual understanding of adjustment to MS diagnosis. Methods: Five electronic databas... Read More about Experiences of receiving a diagnosis of multiple sclerosis: a meta-synthesis of qualitative studies.

Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke (2022)
Journal Article
Msayib, Y., Harston, G. W., Ray, K. J., Larkin, J. R., Sutherland, B. A., Sheerin, F., …Chappell, M. A. (2022). Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke. Magnetic Resonance in Medicine, 88(1), 341-356. https://doi.org/10.1002/mrm.29187

Purpose: In chemical exchange saturation transfer imaging, saturation effects between (Formula presented.) 2 to (Formula presented.) 5 ppm (nuclear Overhauser effects, NOEs) have been shown to exhibit contrast in preclinical stroke models. Our previo... Read More about Quantitative chemical exchange saturation transfer imaging of nuclear overhauser effects in acute ischemic stroke.

Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC) (2022)
Journal Article
Tench, C., Tanasescu, R., Constantinescu, C., Auer, D., & Cottam, W. (2022). Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC). Journal of Neuroscience Methods, 372, Article 109556. https://doi.org/10.1016/j.jneumeth.2022.109556

Background: Functional MRI and voxel-based morphometry are important in neuroscience. They are technically challenging with no globally optimal analysis method, and the multiple approaches have been shown to produce different results. It is useful to... Read More about Easy to interpret Coordinate Based Meta-Analysis of neuroimaging studies: Analysis of Brain Coordinates (ABC).

Dataset of British English speech recordings for psychoacoustics and speech processing research: The clarity speech corpus (2022)
Journal Article
Graetzer, S., Akeroyd, M. A., Barker, J., Cox, T. J., Culling, J. F., Naylor, G., …Viveros-Muñoz, R. (2022). Dataset of British English speech recordings for psychoacoustics and speech processing research: The clarity speech corpus. Data in Brief, 41, Article 107951. https://doi.org/10.1016/j.dib.2022.107951

This paper presents the Clarity Speech Corpus, a publicly available, forty speaker British English speech dataset. The corpus was created for the purpose of running listening tests to gauge speech intelligibility and quality in the Clarity Project, w... Read More about Dataset of British English speech recordings for psychoacoustics and speech processing research: The clarity speech corpus.

Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space (2022)
Preprint / Working Paper
Warrington, S., Thompson, E., Bastiani, M., Dubois, J., Baxter, L., Slater, R., …Sotiropoulos, S. N. Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space

Developmental and evolutionary effects on brain organisation are complex, yet linked, as evidenced by the striking correspondence in cortical expansion changes. However, it is still not possible to study concurrently the ontogeny and phylogeny of cor... Read More about Concurrent mapping of brain ontogeny and phylogeny within a common connectivity space.

Smartphone App–Based Noncontact Ecological Momentary Assessment With Experienced and Naïve Older Participants: Feasibility Study (2022)
Journal Article
Burke, L., & Naylor, G. (2022). Smartphone App–Based Noncontact Ecological Momentary Assessment With Experienced and Naïve Older Participants: Feasibility Study. JMIR Formative Research, 6(3), Article e27677. https://doi.org/10.2196/27677

Background:
Smartphone app–based ecological momentary assessment (EMA) without face-to-face contact between researcher and participant (app-based noncontact EMA) potentially provides a valuable data collection tool when geographic, time, and situati... Read More about Smartphone App–Based Noncontact Ecological Momentary Assessment With Experienced and Naïve Older Participants: Feasibility Study.

Complementary and Alternative Medicine and Tinnitus (2022)
Book Chapter
Crundwell, G., & Baguley, D. M. (2022). Complementary and Alternative Medicine and Tinnitus. In A. K. Deshpande, & J. W. Hall III (Eds.), Tinnitus: Advances in Prevention, Assessment, and Management. Plural Publishing

An Exploratory Investigation of Pupillometry As a Measure of Tinnitus Intrusiveness on a Test of Auditory Short-Term Memory (2022)
Journal Article
Barrett, D. J., Souto, D., Pilling, M., & Baguley, D. M. (2022). An Exploratory Investigation of Pupillometry As a Measure of Tinnitus Intrusiveness on a Test of Auditory Short-Term Memory. Ear and Hearing, 43(5), 1540-1548. https://doi.org/10.1097/AUD.0000000000001214

Objectives: The purpose of the current study was to investigate the potential of pupillometry to provide an objective measure of competition between tinnitus and external sounds during a test of auditory short-term memory. Design: Twelve participants... Read More about An Exploratory Investigation of Pupillometry As a Measure of Tinnitus Intrusiveness on a Test of Auditory Short-Term Memory.