All Outputs (1126)

The Developing Human Connectome Project Neonatal Data Release (2022)
Journal Article
Edwards, A. D., Rueckert, D., Smith, S. M., Seada, S. A., Alansary, A., Almalbis, J., …Hajnal, J. V. (2022). The Developing Human Connectome Project Neonatal Data Release. Frontiers in Neuroscience, 16, Article 886772. https://doi.org/10.3389/fnins.2022.886772

The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating typical and atypical brain development across the perinatal period. It has collected 1228 multimodal magnetic res... Read More about The Developing Human Connectome Project Neonatal Data Release.

Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia (2022)
Journal Article
Hosseini, A. A., Brown, T., Mannino, L., Gran, B., Junaid, K., & Mukaetova-Ladinska, E. B. (2022). Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia. Journal of Alzheimer's Disease, 87(2), 771-780. https://doi.org/10.3233/JAD-215650

Background: The differentiation of a preclinical or prodromal Alzheimer's disease (AD) is challenging particularly in patients with early onset Alzheimer's or related dementias (EOARD). We report our experience on diagnostic lumbar puncture to diagno... Read More about Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia.

Cogmed training does not generalise to real-world benefits for adult hearing aid users: results of a blinded, active-controlled randomised trial (2022)
Journal Article
Henshaw, H., Heinrich, A., Tittle, A., & Ferguson, M. (2022). Cogmed training does not generalise to real-world benefits for adult hearing aid users: results of a blinded, active-controlled randomised trial. Ear and Hearing, 43(3), 741-763. https://doi.org/10.1097/AUD.0000000000001096

Objectives: Performance on working memory tasks is positively associated with speech-in-noise perception performance, particularly where auditory inputs are degraded. It is suggested that interventions designed to improve working memory capacity may... Read More about Cogmed training does not generalise to real-world benefits for adult hearing aid users: results of a blinded, active-controlled randomised trial.

A Systematic Review and Meta-Analysis of Extended High-Frequency Hearing Thresholds in Tinnitus With a Normal Audiogram (2022)
Journal Article
Jafari, Z., Baguley, D., Kolb, B. E., & Mohajerani, M. H. (2022). A Systematic Review and Meta-Analysis of Extended High-Frequency Hearing Thresholds in Tinnitus With a Normal Audiogram. Ear and Hearing, 43(6), 1643-1652. https://doi.org/10.1097/AUD.0000000000001229

OBJECTIVES: Current evidence supports the growing application of extended high-frequency (EHF: 9 to 20 kHz) audiometry in hearing research, which likely results from the high vulnerability of this frequency region to damage induced by known auditory... Read More about A Systematic Review and Meta-Analysis of Extended High-Frequency Hearing Thresholds in Tinnitus With a Normal Audiogram.

Effectiveness of acceptance and commitment therapy for improving quality of life and mood in individuals with multiple sclerosis: A systematic review and meta-analysis (2022)
Journal Article
Thompson, B., Moghaddam, N., Evangelou, N., Baufeldt, A., & das Nair, R. (2022). Effectiveness of acceptance and commitment therapy for improving quality of life and mood in individuals with multiple sclerosis: A systematic review and meta-analysis. Multiple Sclerosis and Related Disorders, 63, Article 103862. https://doi.org/10.1016/j.msard.2022.103862

Objective: To review the evidence for the effectiveness of Acceptance and Commitment Therapy (ACT) intervention on quality of life and mood, for individuals with Multiple Sclerosis (MS). Method: A systematic search was conducted of PsycINFO, CINAHL,... Read More about Effectiveness of acceptance and commitment therapy for improving quality of life and mood in individuals with multiple sclerosis: A systematic review and meta-analysis.

Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies (2022)
Journal Article
Na, Y., Jung, J. Y., Tench, C. R., Auer, D. P., & Pyun, S. B. (2022). Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies. NeuroImage: Clinical, 35, Article 103038. https://doi.org/10.1016/j.nicl.2022.103038

Background: Aphasia is one of the most common causes of post-stroke disabilities. As the symptoms and impact of post-stroke aphasia are heterogeneous, it is important to understand how topographical lesion heterogeneity in patients with aphasia is as... Read More about Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies.

Association Between Use of a Flying Intervention Team vs Patient Interhospital Transfer and Time to Endovascular Thrombectomy Among Patients With Acute Ischemic Stroke in Nonurban Germany (2022)
Journal Article
Hubert, G. J., Hubert, N. D., Maegerlein, C., Kraus, F., Wiestler, H., Müller-Barna, P., …Haberl, R. L. (2022). Association Between Use of a Flying Intervention Team vs Patient Interhospital Transfer and Time to Endovascular Thrombectomy Among Patients With Acute Ischemic Stroke in Nonurban Germany. Journal of the American Medical Association, 327(18), 1795-1805. https://doi.org/10.1001/jama.2022.5948

Importance: The benefit of endovascular thrombectomy (EVT) for acute ischemic stroke is highly time-dependent, and it is challenging to expedite treatment for patients in remote areas. Objective: To determine whether deployment of a flying interventi... Read More about Association Between Use of a Flying Intervention Team vs Patient Interhospital Transfer and Time to Endovascular Thrombectomy Among Patients With Acute Ischemic Stroke in Nonurban Germany.

UK clinical approaches to address post-stroke fatigue: findings from The Nottingham Fatigue after Stroke study (2022)
Journal Article
Ablewhite, J., Condon, L., das Nair, R., Jones, A., Jones, F., Nouri, F., …Drummond, A. (2022). UK clinical approaches to address post-stroke fatigue: findings from The Nottingham Fatigue after Stroke study. International Journal of Therapy and Rehabilitation, 29(5), 1-12. https://doi.org/10.12968/ijtr.2021.0163

Background/aims Although post-stroke is common and debilitating, there is little published research on how it is managed by clinicians. The aim of this study was to document UK management of post-stroke fatigue and ascertain whether there are any dif... Read More about UK clinical approaches to address post-stroke fatigue: findings from The Nottingham Fatigue after Stroke study.

Does audio-visual information result in improved health-related decision-making compared with audio-only or visual-only information? Protocol for a systematic review and meta-analysis (2022)
Journal Article
Stacey, J. E., Atkin, C., Henshaw, H., Roberts, K. L., Allen, H. A., Justice, L. V., & Badham, S. P. (2022). Does audio-visual information result in improved health-related decision-making compared with audio-only or visual-only information? Protocol for a systematic review and meta-analysis. BMJ Open, 12(4), Article e059599. https://doi.org/10.1136/bmjopen-2021-059599

INTRODUCTION: Making health-related decisions can be difficult due to the amount and complexity of information available. Audio-visual information may improve memory for health information but whether audio-visual information can enhance health-relat... Read More about Does audio-visual information result in improved health-related decision-making compared with audio-only or visual-only information? Protocol for a systematic review and meta-analysis.

Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation (2022)
Journal Article
Mistry, S., Das, A., Saffaran, S., Yehya, N., Scott, T. E., Chikhani, M., …Bates, D. G. (2022). Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation. Respiratory Research, 23, Article 101. https://doi.org/10.1186/s12931-022-01985-z

Background: Airway pressure release ventilation (APRV) is widely available on mechanical ventilators and has been proposed as an early intervention to prevent lung injury or as a rescue therapy in the management of refractory hypoxemia. Driving press... Read More about Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation.

Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors (2022)
Journal Article
Zhou, J., Zaiss, M., Knutsson, L., Sun, P. Z., Ahn, S. S., Aime, S., …Zijl, P. C. M. (2022). Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors. Magnetic Resonance in Medicine, 88(2), 546-574. https://doi.org/10.1002/mrm.29241

Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imag... Read More about Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors.

Inhibition of oxidative stress delays senescence and augments functional capacity of endothelial progenitor cells (2022)
Journal Article
Reskiawan A. Kadir, R., Alwjwaj, M., Ahmad Othman, O., Rakkar, K., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2022). Inhibition of oxidative stress delays senescence and augments functional capacity of endothelial progenitor cells. Brain Research, 1787, Article 147925. https://doi.org/10.1016/j.brainres.2022.147925

Ageing is characterised by a progressive loss of vascular endothelial function and integrity. Endothelial progenitor cells (EPCs) play an integral role in endothelial regeneration but are prone to age-dependent changes which may accelerate their sene... Read More about Inhibition of oxidative stress delays senescence and augments functional capacity of endothelial progenitor cells.

Perceived Listening Difficulties of Adult Cochlear-Implant Users Under Measures Introduced to Combat the Spread of COVID-19 (2022)
Journal Article
Perea Pérez, F., Hartley, D. E., Kitterick, P. T., & Wiggins, I. M. (2022). Perceived Listening Difficulties of Adult Cochlear-Implant Users Under Measures Introduced to Combat the Spread of COVID-19. Trends in Hearing, 26, 1-22. https://doi.org/10.1177/23312165221087011

Following the outbreak of the COVID-19 pandemic, public-health measures introduced to stem the spread of the disease caused profound changes to patterns of daily-life communication. This paper presents the results of an online survey conducted to doc... Read More about Perceived Listening Difficulties of Adult Cochlear-Implant Users Under Measures Introduced to Combat the Spread of COVID-19.

Lessons learned from the COVID-19 pandemic about sample access for research in the UK (2022)
Journal Article
Mai Sims, J., Lawrence, E., Glazer, K., Gander, A., Fuller, B., Garibaldi, J., …Quinlan, P. R. (2022). Lessons learned from the COVID-19 pandemic about sample access for research in the UK. BMJ Open, 12(4), Article e047309. https://doi.org/10.1136/bmjopen-2020-047309

Objective Annotated clinical samples taken from patients are a foundation of translational medical research and give mechanistic insight into drug trials. Prior research by the Tissue Directory and Coordination Centre (TDCC) indicated that researcher... Read More about Lessons learned from the COVID-19 pandemic about sample access for research in the UK.

MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial (2022)
Journal Article
Rodriguez, D., Calmon, R., Aliaga, E. S., Warren, D., Warmuth-Metz, M., Jones, C., …Jaspan, T. (2022). MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial. Radiology, 304(1), 174-182. https://doi.org/10.1148/radiol.211464

Background Diffuse midline gliomas (DMG) are characterized by a high incidence of H3 K27 mutations and poorer outcome. The HERBY trial has provided one of the largest cohorts of pediatric DMGs with available radiologic, histologic-genotypic, and surv... Read More about MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial.

Amide proton transfer imaging in stroke (2022)
Journal Article
Heo, H. Y., Tee, Y. K., Harston, G., Leigh, R., & Chappell, M. A. (2022). Amide proton transfer imaging in stroke. NMR in Biomedicine, Article e4734. https://doi.org/10.1002/nbm.4734

Amide proton transfer (APT) imaging, a variant of chemical exchange saturation transfer MRI, has shown promise in detecting ischemic tissue acidosis following impaired aerobic metabolism in animal models and in human stroke patients due to the sensit... Read More about Amide proton transfer imaging in stroke.

Determining the Effects of Transcranial Direct Current Stimulation on Tinnitus, Depression, and Anxiety: A Systematic Review (2022)
Journal Article
Labree, B., Hoare, D. J., Gascoyne, L. E., Scutt, P., Del Giovane, C., & Sereda, M. (2022). Determining the Effects of Transcranial Direct Current Stimulation on Tinnitus, Depression, and Anxiety: A Systematic Review. Brain Sciences, 12(4), Article 484. https://doi.org/10.3390/brainsci12040484

Background: Tinnitus is the awareness of a sound in the absence of an external source. It affects around 10–15% of people, a significant proportion of whom also experience symptoms such as depression or anxiety that negatively affect their quality of... Read More about Determining the Effects of Transcranial Direct Current Stimulation on Tinnitus, Depression, and Anxiety: A Systematic Review.

Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research (2022)
Journal Article
Senekowitsch, S., Schick, P., Abrahamsson, B., Augustijns, P., Gießmann, T., Lennernäs, H., …Koziolek, M. (2022). Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research. Pharmaceutics, 14(4), Article 801. https://doi.org/10.3390/pharmaceutics14040801

Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST action on “Un... Read More about Application of in vivo imaging techniques and diagnostic tools in oral drug delivery research.

Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic (2022)
Journal Article
Ali, W., Elsahn, A., Ting, D. S. J., Dua, H. S., & Mohammed, I. (2022). Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic. Antibiotics, 11(4), Article 475. https://doi.org/10.3390/antibiotics11040475

One of the greatest challenges facing the medical community today is the ever-increasing trajectory of antimicrobial resistance (AMR), which is being compounded by the decrease in our antimicrobial armamentarium. From their initial discovery to the c... Read More about Host Defence Peptides: A Potent Alternative to Combat Antimicrobial Resistance in the Era of the COVID-19 Pandemic.

Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments (2022)
Journal Article
Brosnan, M. B., Shalev, N., Ramduny, J., Sotiropoulos, S. N., & Chechlacz, M. (2022). Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments. Brain Communications, 4(2), Article fcac080. https://doi.org/10.1093/braincomms/fcac080

Exposure to enriched environments throughout a lifetime, providing so-called reserve, protects against cognitive decline in later years. It has been hypothesized that high levels of alertness necessitated by enriched environments might strengthen the... Read More about Right fronto-parietal networks mediate the neurocognitive benefits of enriched environments.