Skip to main content

Research Repository

Advanced Search

All Outputs (128)

High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study (2021)
Journal Article
Weaver, L., Das, A., Saffaran, S., Yehya, N., Scott, T. E., Chikhani, M., …Bates, D. G. (2021). High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study. Annals of Intensive Care, 11(1), Article 109. https://doi.org/10.1186/s13613-021-00904-7

Background: There is ongoing controversy regarding the potential for increased respiratory effort to generate patient self-inflicted lung injury (P-SILI) in spontaneously breathing patients with COVID-19 acute hypoxaemic respiratory failure. However,... Read More about High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study.

Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T (2021)
Journal Article
Dewey, R. S., Dineen, R. A., Clemence, M., Dick, O., Bowtell, R., & Kitterick, P. T. (2021). Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T. Otology and Neurotology, 42(10), e1449-e1456. https://doi.org/10.1097/MAO.0000000000003281

Background:Brain magnetic resonance imaging in patients with cochlear implants (CIs) is impacted by image artefacts.Hypothesis:The optimal positioning of the CI to minimize artefacts is unknown. This study aimed to characterize the dependence of the... Read More about Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T.

Telehealth rehabilitation for adults with cochlear implants in response to the Covid-19 pandemic: platform selection and case studies (2021)
Journal Article
Carter, J. M., Killan, C. F., & Ridgwell, J. J. (2022). Telehealth rehabilitation for adults with cochlear implants in response to the Covid-19 pandemic: platform selection and case studies. Cochlear Implants International, 23(1), 43-51. https://doi.org/10.1080/14670100.2021.1949524

Background
Effective information giving and goal setting before cochlear implantation and individualised rehabilitation following implantation are both crucial for shaping patients’ expectations and optimising outcomes. The Covid-19 pandemic led to... Read More about Telehealth rehabilitation for adults with cochlear implants in response to the Covid-19 pandemic: platform selection and case studies.

Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes (2021)
Journal Article
Song, A., Deshmukh, R., Lin, H., Ang, M., Mehta, J. S., Chodosh, J., …Ting, D. S. (2021). Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes. Frontiers in Medicine, 8, Article 707242. https://doi.org/10.3389/fmed.2021.707242

Post-keratoplasty infectious keratitis (PKIK) represents a unique clinical entity that often poses significant diagnostic and therapeutic challenges. It carries a high risk of serious complications such as graft rejection and failure, and less common... Read More about Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections [version 1; peer review: 1 approved with reservations] (2021)
Journal Article
Bath, P. M., Coleman, C. M., Gordon, A. L., Lim, W. S., & Webb, A. J. (2021). Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections [version 1; peer review: 1 approved with reservations]. F1000Research, 10, 1-34. https://doi.org/10.12688/f1000research.51270.1

Although the antimicrobial potential of nitric oxide (NO) is widely published, it is little used clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and immune responses. Endogenous antimicrobial activity is largel... Read More about Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections [version 1; peer review: 1 approved with reservations].

The Utility of Economic Measures to Quantify the Burden of Tinnitus in Affected Individuals: A Scoping Review (2021)
Journal Article
Daoud, E., Caimino, C., Akeroyd, M. A., Noreña, A. J., & Baguley, D. M. (2022). The Utility of Economic Measures to Quantify the Burden of Tinnitus in Affected Individuals: A Scoping Review. PharmacoEconomics - Open, 6, 21-32. https://doi.org/10.1007/s41669-021-00273-8

Background and objectives
Tinnitus is a chronic subjective condition that impacts patients’ health-related quality of life (HRQoL) and requires multidisciplinary interventions. In health economics, quality-adjusted life years (QALYs) and willingness... Read More about The Utility of Economic Measures to Quantify the Burden of Tinnitus in Affected Individuals: A Scoping Review.

Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI (2021)
Journal Article
Dewey, R. S., Hall, D. A., Plack, C. J., & Francis, S. T. (2021). Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI. Magnetic Resonance in Medicine, 86(5), 2577-2588. https://doi.org/10.1002/mrm.28902

Purpose
Detecting sound-related activity using functional MRI requires the auditory stimulus to be more salient than the intense background scanner acoustic noise. Various strategies can reduce the impact of scanner acoustic noise, including “sparse... Read More about Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI.

The effects of dual-task interference in predicting turn-ends in speech and music (2021)
Journal Article
Fisher, N. K., Hadley, L. V., Corps, R. E., & Pickering, M. J. (2021). The effects of dual-task interference in predicting turn-ends in speech and music. Brain Research, 1768, Article 147571. https://doi.org/10.1016/j.brainres.2021.147571

Determining when a partner’s spoken or musical turn will end requires well-honed predictive abilities. Evidence suggests that our motor systems are activated during perception of both speech and music, and it has been argued that motor simulation is... Read More about The effects of dual-task interference in predicting turn-ends in speech and music.

Hyperacusis：a mini review (2021)
Journal Article
Zhang, D., Xu, Q., & Baguley, D. (2021). Hyperacusis：a mini review. Journal of Clinical Otorhinolaryngology Head and Neck Surgery (临床耳鼻咽喉头颈外科杂志), 2021(6), 563-566

Hyperacusis refers to the experience of the sound environment being perceived as overwhelming loud or painful, and this can severely affect the patient's quality of life. In China little attention has been paid to hyperacusis, and there has been litt... Read More about Hyperacusis：a mini review.

EPEN-04. SIOP EPENDYMOMA I: FINAL RESULTS, LONG TERM FOLLOW-UP AND MOLECULAR ANALYSIS OF THE TRIAL COHORT: A BIOMECA CONSORTIUM STUDY (2021)
Journal Article
Ritzmann, T. A., Chapman, R. J., Macarthur, D., Mallucci, C., Kilday, J.-P., Thorp, N., …Grundy, R. G. (2021). EPEN-04. SIOP EPENDYMOMA I: FINAL RESULTS, LONG TERM FOLLOW-UP AND MOLECULAR ANALYSIS OF THE TRIAL COHORT: A BIOMECA CONSORTIUM STUDY. Neuro-Oncology, 23(Supplement 1), i14. https://doi.org/10.1093/neuonc/noab090.054

Introduction
Surgery and radiotherapy are established childhood ependymoma treatments. The efficacy of chemotherapy has been debated. We report final results of the SIOP Ependymoma I trial, with 12-year follow-up, in the context of a post-hoc analys... Read More about EPEN-04. SIOP EPENDYMOMA I: FINAL RESULTS, LONG TERM FOLLOW-UP AND MOLECULAR ANALYSIS OF THE TRIAL COHORT: A BIOMECA CONSORTIUM STUDY.

Learning from a successful process evaluation in care homes (2021)
Journal Article
Allen, F., Darby, J., Cook, M., Evley, R., Godfrey, M., Horne, J., …Robinson, K. (2021). Learning from a successful process evaluation in care homes. Age and Ageing, 50(5), 1850-1853. https://doi.org/10.1093/ageing/afab139

Introduction
process evaluations (PE) are increasingly used in parallel with randomised controlled trials (RCT) to inform the implementation of complex health interventions. This paper explores the learning accrued from conducting a PE within the Fa... Read More about Learning from a successful process evaluation in care homes.

Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis (2021)
Journal Article
Ting, D. S. J., Henein, C., Said, D. G., & Dua, H. S. (2021). Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis. Scientific Reports, 11, Article 13007. https://doi.org/10.1038/s41598-021-92366-x

Infectious keratitis (IK) is the 5th leading cause of blindness globally. Broad-spectrum topical antimicrobial treatment is the current mainstay of treatment for IK, though adjuvant treatment or surgeries are often required in refractory cases of IK.... Read More about Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis.

Cognitive measures used in adults with multiple sclerosis: A systematic review (2021)
Journal Article
Elwick, H., Topcu, G., Allen, C. M., Drummond, A., Evangelou, N., & Das Nair, R. (2022). Cognitive measures used in adults with multiple sclerosis: A systematic review. Neuropsychological Rehabilitation, 32(9), 2464-2481. https://doi.org/10.1080/09602011.2021.1936080

Cognitive problems are common in people with Multiple Sclerosis (MS), and researchers and clinicians have used a vast array of measures to assess cognition. Our aim was to systematically identify cognitive measures routinely used in MS research, and... Read More about Cognitive measures used in adults with multiple sclerosis: A systematic review.

Effects of Pharyngeal Electrical Stimulation on Swallow Timings, Clearance and Safety in Post-Stroke Dysphagia: Analysis from the Swallowing Treatment Using Electrical Pharyngeal Stimulation (STEPS) Trial (2021)
Journal Article
Everton, L. F., Benfield, J. K., Michou, E., Hamdy, S., & Bath, P. M. (2021). Effects of Pharyngeal Electrical Stimulation on Swallow Timings, Clearance and Safety in Post-Stroke Dysphagia: Analysis from the Swallowing Treatment Using Electrical Pharyngeal Stimulation (STEPS) Trial. Stroke Research and Treatment, 2021, Article 5520657. https://doi.org/10.1155/2021/5520657

Swallowing impairment (dysphagia) post-stroke results in poorer outcomes. Pharyngeal electrical stimulation (PES) is a potential treatment for post-stroke dysphagia. In a post hoc analysis, we investigated PES using videofluoroscopy swallow studies (... Read More about Effects of Pharyngeal Electrical Stimulation on Swallow Timings, Clearance and Safety in Post-Stroke Dysphagia: Analysis from the Swallowing Treatment Using Electrical Pharyngeal Stimulation (STEPS) Trial.

Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far? (2021)
Journal Article
Chappell, M. A., McConnell, F. A. K., Golay, X., Günther, M., Hernandez-Tamames, J. A., van Osch, M. J., & Asllani, I. (2021). Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far?. NeuroImage, 238, Article 118236. https://doi.org/10.1016/j.neuroimage.2021.118236

The mismatch in the spatial resolution of Arterial Spin Labeling (ASL) MRI perfusion images and the anatomy of functionally distinct tissues in the brain leads to a partial volume effect (PVE), which in turn confounds the estimation of perfusion into... Read More about Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far?.

Associations Between Hearing Health and Well-Being in Unilateral Hearing Impairment (2021)
Journal Article
Pierzycki, R. H., Edmondson-Jones, M., Dawes, P., Munro, K. J., Moore, D. R., & Kitterick, P. T. (2021). Associations Between Hearing Health and Well-Being in Unilateral Hearing Impairment. Ear and Hearing, 42(3), 520-530. https://doi.org/10.1097/AUD.0000000000000969

Objectives: To determine population-based risks of adverse effects on hearing and well-being outcomes associated with unilateral hearing impairment.

Design: A group of 40-69-year-old adults (n = 861) who reported being able to hear only in one ear... Read More about Associations Between Hearing Health and Well-Being in Unilateral Hearing Impairment.

Diagnostic accuracy of the Dysphagia Trained Nurse Assessment tool in acute stroke (2021)
Journal Article
Benfield, J. K., Wilkinson, G., Everton, L. F., Bath, P. M., & England, T. J. (2021). Diagnostic accuracy of the Dysphagia Trained Nurse Assessment tool in acute stroke. European Journal of Neurology, 28(8), 2766-2774. https://doi.org/10.1111/ene.14900

Background and purpose
Comprehensive swallow screening assessments to identify dysphagia and make early eating and drinking recommendations can be used by trained nurses. This study aimed to validate the Dysphagia Trained Nurse Assessment (DTNAx) to... Read More about Diagnostic accuracy of the Dysphagia Trained Nurse Assessment tool in acute stroke.

Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells (2021)
Journal Article
Akhtar, R., Tahir, H., Stewart, E., Wei, R., Mohammed, I., & Amoaku, W. M. (2021). Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells. International Journal of Translational Medicine, 1(1), 25-38. https://doi.org/10.3390/ijtm1010003

Retinal diseases are the leading causes of irreversible blindness worldwide. The role of toll-like receptor (TLR) signalling mechanisms (MyD88 and TRIF) in the production of pro-angiogenic growth factors from human microvascular endothelial cells (HM... Read More about Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells.

Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation (2021)
Journal Article
Sorby-Adams, A. J., Learoyd, A. E., Bath, P. M., Burrows, F., Farr, T. D., Leonard, A. V., …Trueman, R. C. (2021). Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation. Journal of Cerebral Blood Flow and Metabolism, 41(12), 3248-3259. https://doi.org/10.1177/0271678X211018901

Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow and infarct... Read More about Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation.