Skip to main content

Research Repository

Advanced Search

All Outputs (106)

The effect of collagen fibril orientation on the biphasic mechanics of articular cartilage (2016)
Journal Article
Meng, Q., An, S., Damion, R. A., Jin, Z., Wilcox, R., Fisher, J., & Jones, A. (2017). The effect of collagen fibril orientation on the biphasic mechanics of articular cartilage. Journal of the Mechanical Behavior of Biomedical Materials, 65, 439-453. https://doi.org/10.1016/j.jmbbm.2016.09.001

The highly inhomogeneous distribution of collagen fibrils may have important effects on the biphasic mechanics of articular cartilage. However, the effect of the inhomogeneity of collagen fibrils has mainly been investigated using simplified three-la... Read More about The effect of collagen fibril orientation on the biphasic mechanics of articular cartilage.

Neuroanatomical Alterations in Tinnitus Assessed with Magnetic Resonance Imaging (2016)
Journal Article
Allan, T. W., Besle, J., Langers, D. R., Davies, J., Hall, D. A., Palmer, A. R., & Adjamian, P. (2016). Neuroanatomical Alterations in Tinnitus Assessed with Magnetic Resonance Imaging. Frontiers in Aging Neuroscience, 8, Article 221. https://doi.org/10.3389/fnagi.2016.00221

Previous studies of anatomical changes associated with tinnitus have provided inconsistent results, with some showing significant cortical and subcortical changes, while others have found effects due to hearing loss, but not tinnitus. In this study,... Read More about Neuroanatomical Alterations in Tinnitus Assessed with Magnetic Resonance Imaging.

Domains relating to the everyday impact of hearing loss, as reported by patients or their communication partner(s): protocol for a systematic review (2016)
Journal Article
Vas, V., Akeroyd, M. A., & Hall, D. A. (2016). Domains relating to the everyday impact of hearing loss, as reported by patients or their communication partner(s): protocol for a systematic review. BMJ Open, 6(9), 1-6. https://doi.org/10.1136/bmjopen-2016-011463

INTRODUCTION: Hearing loss is a highly prevalent condition that affects around 1 in 6 people in the UK alone. This number is predicted to rise by the year 2031 to a staggering 14.5 million people due to the ageing population of the UK. Currently, th... Read More about Domains relating to the everyday impact of hearing loss, as reported by patients or their communication partner(s): protocol for a systematic review.

Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease (2016)
Journal Article
Meng, D., Hosseini, A. A., Simpson, R. J., Shaikh, Q., Tench, C. R., Dineen, R. A., & Auer, D. P. (2017). Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease. Radiology, 282(2), 502-515. https://doi.org/10.1148/radiol.2016152685

Purpose: To investigate associations between neuroimaging markers of cerebrovascular disease, including lesion topography and extent and severity of strategic and global cerebral tissue injury, and cognition in carotid artery disease (CAD). Material... Read More about Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease.

Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730) (2016)
Journal Article
Sprigg, N., O’Connor, R., Woodhouse, L. J., Krishnan, K., England, T. J., Connell, L. A., …Bath, P. M. (2016). Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730). PLoS ONE, 11(9), Article e0161359. https://doi.org/10.1371/journal.pone.0161359

Background Granulocyte-colony stimulating factor (G-CSF) mobilises endogenous haematopoietic stem cells and enhances recovery in experimental stroke. Recovery may also be dependent on an enriched environment and physical activity. G-CSF may have the... Read More about Granulocyte Colony Stimulating Factor and Physiotherapy after Stroke: Results of a Feasibility Randomised Controlled Trial: Stem Cell Trial of Recovery EnhanceMent after Stroke-3 (STEMS-3 ISRCTN16714730).

Imaging central veins in brain lesions with 3-T T2*-weighted magnetic resonance imaging differentiates multiple sclerosis from microangiopathic brain lesions (2016)
Journal Article
Mistry, N., Abdel-Fahim, R., Samaraweera, A., Mougin, O., Tallantyre, E., Tench, C., …Evangelou, N. (2016). Imaging central veins in brain lesions with 3-T T2*-weighted magnetic resonance imaging differentiates multiple sclerosis from microangiopathic brain lesions. Multiple Sclerosis Journal, 22(10), 1289-1296. https://doi.org/10.1177/1352458515616700

Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity (2016)
Journal Article
Li, X., Zhang, Y., Yan, Y., Ciric, B., Ma, C. G., Gran, B., …Zhang, G. X. (2016). Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity. Molecular Therapy, 24(8), 1456-1469. https://doi.org/10.1038/mt.2016.104

© The American Society of Gene and Cell Therapy. Treatment of chronic neurodegenerative diseases such as multiple sclerosis (MS) remains a major challenge. Here we genetically engineer neural stem cells (NSCs) to produce a triply therapeutic cocktail... Read More about Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity.

On the (un)importance of working memory in speech-in-noise processing for listeners with normal hearing thresholds (2016)
Journal Article
Füllgrabe, C., & Rosen, S. (2016). On the (un)importance of working memory in speech-in-noise processing for listeners with normal hearing thresholds. Frontiers in Psychology, 7, Article 1268. https://doi.org/10.3389/fpsyg.2016.01268

With the advent of cognitive hearing science, increased attention has been given to individual differences in cognitive functioning and their explanatory power in accounting for inter-listener variability in the processing of speech in noise (SiN). T... Read More about On the (un)importance of working memory in speech-in-noise processing for listeners with normal hearing thresholds.

Animated educational video to prepare children for MRI without sedation: evaluation of the appeal and value (2016)
Journal Article
Szeszak, S., Man, R., Love, A., Langmack, G., Wharrad, H., & Dineen, R. A. (2016). Animated educational video to prepare children for MRI without sedation: evaluation of the appeal and value. Pediatric Radiology, 46(12), 1744-1750. https://doi.org/10.1007/s00247-016-3661-4

Background: MRI scans can be distressing for children and often require sedation. Educating children about what to expect reduces anxiety and increases likelihood of successful non-sedated MRI scans. Multimedia tools are a popular means of education.... Read More about Animated educational video to prepare children for MRI without sedation: evaluation of the appeal and value.

Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults (2016)
Journal Article
Kitterick, P. T., Smith, S. N., & Lucas, L. (2016). Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults. Ear and Hearing, 37(5), https://doi.org/10.1097/AUD.0000000000000313

Objectives: A systematic review of the literature and meta-analysis was conducted to assess the nature and quality of the evidence for the use of hearing instruments in adults with a unilateral severe-to-profound sensorineural hearing loss. Design:... Read More about Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults.

Recovery is no laughing matter – or is it? (2016)
Journal Article
Barker, A. B., & Winship, G. (2016). Recovery is no laughing matter – or is it?. Mental Health and Social Inclusion, 20(3), 167-173. https://doi.org/10.1108/MHSI-02-2016-0006

Purpose - The purpose of this paper is to describe an exploratory pilot study to assess the methods used to evaluate an innovative programme of comedy workshops for a small cohort of people recovering from substance misuse problems. The comedy works... Read More about Recovery is no laughing matter – or is it?.

Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study (2016)
Journal Article
Kalladka, D., Sinden, J., Pollock, K., Haig, C., McLean, J., Smith, W., …Muir, K. W. (2016). Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet, 388(10046), 787-796. https://doi.org/10.1016/S0140-6736%2816%2930513-X

Background: CTX0E03 is an immortalised human neural stem-cell line from which a drug product (CTX-DP) was developed for allogeneic therapy. Dose-dependent improvement in sensorimotor function in rats implanted with CTX-DP 4 weeks after middle cerebra... Read More about Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study.

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research (2016)
Journal Article
Dichgans, M., Wardlaw, J., Smith, E., Zietemann, V., Seshadri, S., Sachdev, P., …Yang, Y. (in press). METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimer's and Dementia, https://doi.org/10.1016/j.jalz.2016.06.004

Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuse... Read More about METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: an initiative of the Joint Programme for Neurodegenerative Disease Research.

A taxonomy of fatigue concepts and their relation to hearing loss (2016)
Journal Article
Hornsby, B. W., Naylor, G., & Bess, F. H. (2016). A taxonomy of fatigue concepts and their relation to hearing loss. Ear and Hearing, 37(Supp 1), Article 136S-144S. https://doi.org/10.1097/AUD.0000000000000289

Fatigue is common in individuals with a variety of chronic health conditions and can have significant negative effects on quality of life. Although limited in scope, recent work suggests persons with hearing loss may be at increased risk for fatigue,... Read More about A taxonomy of fatigue concepts and their relation to hearing loss.

Plasticity in bilateral superior temporal cortex: Effects of deafness and cochlear implantation on auditory and visual speech processing (2016)
Journal Article
Anderson, C. A., Lazard, D. S., & Hartley, D. E. (2017). Plasticity in bilateral superior temporal cortex: Effects of deafness and cochlear implantation on auditory and visual speech processing. Hearing Research, 343, 138-149. https://doi.org/10.1016/j.heares.2016.07.013

While many individuals can benefit substantially from cochlear implantation, the ability to perceive and understand auditory speech with a cochlear implant (CI) remains highly variable amongst adult recipients. Importantly, auditory performance with... Read More about Plasticity in bilateral superior temporal cortex: Effects of deafness and cochlear implantation on auditory and visual speech processing.

Speech-evoked activation in adult temporal cortex measured using functional near-infrared spectroscopy (fNIRS): Are the measurements reliable? (2016)
Journal Article
Wiggins, I. M., Anderson, C. A., Kitterick, P. T., & Hartley, D. E. (2016). Speech-evoked activation in adult temporal cortex measured using functional near-infrared spectroscopy (fNIRS): Are the measurements reliable?. Hearing Research, 339, 142-154. https://doi.org/10.1016/j.heares.2016.07.007

Functional near-infrared spectroscopy (fNIRS) is a silent, non-invasive neuroimaging technique that is potentially well suited to auditory research. However, the reliability of auditory-evoked activation measured using fNIRS is largely unknown. The p... Read More about Speech-evoked activation in adult temporal cortex measured using functional near-infrared spectroscopy (fNIRS): Are the measurements reliable?.

Lymphocryptovirus infection of nonhuman primate b cells converts destructive into productive processing of the pathogenic CD8 T Cell epitope in myelin oligodendrocyte glycoprotein (2016)
Journal Article
Jagessar, S. A., Holtman, I. R., Hofman, S., Morandi, E., Heijmans, N., Laman, J. D., …‘t Hart, B. A. (2016). Lymphocryptovirus infection of nonhuman primate b cells converts destructive into productive processing of the pathogenic CD8 T Cell epitope in myelin oligodendrocyte glycoprotein. Journal of Immunology, 197(4), 1074-1088. https://doi.org/10.4049/jimmunol.1600124

Copyright © 2016 by The American Association of Immunologists, Inc. EBVis the major infectious environmental risk factor for multiple sclerosis (MS), but the underlying mechanisms remain obscure. Patient studies do not allow manipulation in vivo. We... Read More about Lymphocryptovirus infection of nonhuman primate b cells converts destructive into productive processing of the pathogenic CD8 T Cell epitope in myelin oligodendrocyte glycoprotein.

The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research (2016)
Journal Article
Bath, P. M., Appleton, J. P., & Sprigg, N. (in press). The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research. International Journal of Stroke, https://doi.org/10.1177/1747493016660099

The prevention of recurrent events after ischaemic stroke and transient ischaemic attack is well established and based on lifestyle changes, antithrombotics, statins, antihypertensives and carotid surgery. The international IRIS trial assessed whethe... Read More about The Insulin Resistance Intervention after Stroke trial: a perspective on future practice and research.

Theoretical issues of validity in the measurement of aided speech reception threshold in noise for comparing nonlinear hearing aid systems (2016)
Journal Article
Naylor, G. (2016). Theoretical issues of validity in the measurement of aided speech reception threshold in noise for comparing nonlinear hearing aid systems. Journal of the American Academy of Audiology, 27(7), https://doi.org/10.3766/jaaa.15093

Background: Adaptive Speech Reception Threshold in noise (SRTn) measurements are often used to make comparisons between alternative hearing aid (HA) systems. Such measurements usually do not constrain the signal-to-noise ratio (SNR) at which testing... Read More about Theoretical issues of validity in the measurement of aided speech reception threshold in noise for comparing nonlinear hearing aid systems.