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Preferential Cochleotoxicity of Cisplatin (2021)
Journal Article
Prayuenyong, P., Baguley, D. M., Kros, C. J., & Steyger, P. S. (2021). Preferential Cochleotoxicity of Cisplatin. Frontiers in Neuroscience, 15, Article 695268. https://doi.org/10.3389/fnins.2021.695268

Cisplatin-induced ototoxicity in humans is more predominant in the cochlea than in the vestibule. Neither definite nor substantial vestibular dysfunction after cisplatin treatment has been consistently reported in the current literature. Inner ear ha... Read More about Preferential Cochleotoxicity of Cisplatin.

Prevalence of Hyperacusis and Its Relation to Health: The Busselton Healthy Ageing Study (2021)
Journal Article
Smit, A. L., Stegeman, I., Eikelboom, R. H., Baguley, D. M., Bennett, R. J., Tegg-Quinn, S., …Atlas, M. D. (2021). Prevalence of Hyperacusis and Its Relation to Health: The Busselton Healthy Ageing Study. Laryngoscope, 131(12), E2887-E2896. https://doi.org/10.1002/lary.29768

Importance The prevalence of hyperacusis and its relationship with mental and general health is unknown in a nonclinical sample. Therefore, we aimed to determine the prevalence of hyperacusis and its relation with hearing, general and mental health... Read More about Prevalence of Hyperacusis and Its Relation to Health: The Busselton Healthy Ageing Study.

Quality of Life and Psychological Distress in Portuguese Older Individuals with Tinnitus (2021)
Journal Article
Haider, H. F., Ribeiro, S. F., Hoare, D. J., Fialho, G., Hall, D. A., Antunes, M., …Paço, J. (2021). Quality of Life and Psychological Distress in Portuguese Older Individuals with Tinnitus. Brain Sciences, 11(7), Article 953. https://doi.org/10.3390/brainsci11070953

Tinnitus is the perception of a sound without an external source, often associated with adverse psychological and emotional effects leading to impaired quality of life (QoL). The present study investigated QoL and psychological distress in tinnitus p... Read More about Quality of Life and Psychological Distress in Portuguese Older Individuals with Tinnitus.

Acceptance-based telephone support around the time of transition to secondary progressive multiple sclerosis: A feasibility randomised controlled trial (2021)
Journal Article
Meek, C., Moghaddam, N. G., Evangelou, N., Oates, L. L., Topcu, G., Allen, C., & das Nair, R. (2021). Acceptance-based telephone support around the time of transition to secondary progressive multiple sclerosis: A feasibility randomised controlled trial. Journal of Contextual Behavioral Science, 21, 158-170. https://doi.org/10.1016/j.jcbs.2021.07.001

Introduction Transitioning to secondary progressive multiple sclerosis (SPMS) is a difficult time for people, fraught with psychological uncertainty and an increase in physical disability. In parallel, healthcare appointments become less frequent, m... Read More about Acceptance-based telephone support around the time of transition to secondary progressive multiple sclerosis: A feasibility randomised controlled trial.

High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study (2021)
Journal Article
Weaver, L., Das, A., Saffaran, S., Yehya, N., Scott, T. E., Chikhani, M., …Bates, D. G. (2021). High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study. Annals of Intensive Care, 11(1), Article 109. https://doi.org/10.1186/s13613-021-00904-7

Background: There is ongoing controversy regarding the potential for increased respiratory effort to generate patient self-inflicted lung injury (P-SILI) in spontaneously breathing patients with COVID-19 acute hypoxaemic respiratory failure. However,... Read More about High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study.

Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T (2021)
Journal Article
Dewey, R. S., Dineen, R. A., Clemence, M., Dick, O., Bowtell, R., & Kitterick, P. T. (2021). Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T. Otology and Neurotology, 42(10), e1449-e1456. https://doi.org/10.1097/MAO.0000000000003281

Background:Brain magnetic resonance imaging in patients with cochlear implants (CIs) is impacted by image artefacts.Hypothesis:The optimal positioning of the CI to minimize artefacts is unknown. This study aimed to characterize the dependence of the... Read More about Parametric Assessment of the Effect of Cochlear Implant Positioning on Brain MRI Artefacts at 3 T.

Telehealth rehabilitation for adults with cochlear implants in response to the Covid-19 pandemic: platform selection and case studies (2021)
Journal Article
Carter, J. M., Killan, C. F., & Ridgwell, J. J. (2022). Telehealth rehabilitation for adults with cochlear implants in response to the Covid-19 pandemic: platform selection and case studies. Cochlear Implants International, 23(1), 43-51. https://doi.org/10.1080/14670100.2021.1949524

Background Effective information giving and goal setting before cochlear implantation and individualised rehabilitation following implantation are both crucial for shaping patients’ expectations and optimising outcomes. The Covid-19 pandemic led to... Read More about Telehealth rehabilitation for adults with cochlear implants in response to the Covid-19 pandemic: platform selection and case studies.

Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes (2021)
Journal Article
Song, A., Deshmukh, R., Lin, H., Ang, M., Mehta, J. S., Chodosh, J., …Ting, D. S. (2021). Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes. Frontiers in Medicine, 8, Article 707242. https://doi.org/10.3389/fmed.2021.707242

Post-keratoplasty infectious keratitis (PKIK) represents a unique clinical entity that often poses significant diagnostic and therapeutic challenges. It carries a high risk of serious complications such as graft rejection and failure, and less common... Read More about Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections [version 1; peer review: 1 approved with reservations] (2021)
Journal Article
Bath, P. M., Coleman, C. M., Gordon, A. L., Lim, W. S., & Webb, A. J. (2021). Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections [version 1; peer review: 1 approved with reservations]. F1000Research, 10, 1-34. https://doi.org/10.12688/f1000research.51270.1

Although the antimicrobial potential of nitric oxide (NO) is widely published, it is little used clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and immune responses. Endogenous antimicrobial activity is largel... Read More about Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections [version 1; peer review: 1 approved with reservations].

The Utility of Economic Measures to Quantify the Burden of Tinnitus in Affected Individuals: A Scoping Review (2021)
Journal Article
Daoud, E., Caimino, C., Akeroyd, M. A., Noreña, A. J., & Baguley, D. M. (2022). The Utility of Economic Measures to Quantify the Burden of Tinnitus in Affected Individuals: A Scoping Review. PharmacoEconomics - Open, 6, 21-32. https://doi.org/10.1007/s41669-021-00273-8

Background and objectives Tinnitus is a chronic subjective condition that impacts patients’ health-related quality of life (HRQoL) and requires multidisciplinary interventions. In health economics, quality-adjusted life years (QALYs) and willingness... Read More about The Utility of Economic Measures to Quantify the Burden of Tinnitus in Affected Individuals: A Scoping Review.

The effects of dual-task interference in predicting turn-ends in speech and music (2021)
Journal Article
Fisher, N. K., Hadley, L. V., Corps, R. E., & Pickering, M. J. (2021). The effects of dual-task interference in predicting turn-ends in speech and music. Brain Research, 1768, Article 147571. https://doi.org/10.1016/j.brainres.2021.147571

Determining when a partner’s spoken or musical turn will end requires well-honed predictive abilities. Evidence suggests that our motor systems are activated during perception of both speech and music, and it has been argued that motor simulation is... Read More about The effects of dual-task interference in predicting turn-ends in speech and music.

Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI (2021)
Journal Article
Dewey, R. S., Hall, D. A., Plack, C. J., & Francis, S. T. (2021). Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI. Magnetic Resonance in Medicine, 86(5), 2577-2588. https://doi.org/10.1002/mrm.28902

Purpose Detecting sound-related activity using functional MRI requires the auditory stimulus to be more salient than the intense background scanner acoustic noise. Various strategies can reduce the impact of scanner acoustic noise, including “sparse... Read More about Comparison of continuous sampling with active noise cancelation and sparse sampling for cortical and subcortical auditory functional MRI.

Hyperacusis：a mini review (2021)
Journal Article
Zhang, D., Xu, Q., & Baguley, D. (2021). Hyperacusis：a mini review. Journal of Clinical Otorhinolaryngology Head and Neck Surgery (临床耳鼻咽喉头颈外科杂志), 2021(6), 563-566

Hyperacusis refers to the experience of the sound environment being perceived as overwhelming loud or painful, and this can severely affect the patient's quality of life. In China little attention has been paid to hyperacusis, and there has been litt... Read More about Hyperacusis：a mini review.

EPEN-04. SIOP EPENDYMOMA I: FINAL RESULTS, LONG TERM FOLLOW-UP AND MOLECULAR ANALYSIS OF THE TRIAL COHORT: A BIOMECA CONSORTIUM STUDY (2021)
Journal Article
Ritzmann, T. A., Chapman, R. J., Macarthur, D., Mallucci, C., Kilday, J.-P., Thorp, N., …Grundy, R. G. (2021). EPEN-04. SIOP EPENDYMOMA I: FINAL RESULTS, LONG TERM FOLLOW-UP AND MOLECULAR ANALYSIS OF THE TRIAL COHORT: A BIOMECA CONSORTIUM STUDY. Neuro-Oncology, 23(Supplement 1), i14. https://doi.org/10.1093/neuonc/noab090.054

Introduction Surgery and radiotherapy are established childhood ependymoma treatments. The efficacy of chemotherapy has been debated. We report final results of the SIOP Ependymoma I trial, with 12-year follow-up, in the context of a post-hoc analys... Read More about EPEN-04. SIOP EPENDYMOMA I: FINAL RESULTS, LONG TERM FOLLOW-UP AND MOLECULAR ANALYSIS OF THE TRIAL COHORT: A BIOMECA CONSORTIUM STUDY.

Learning from a successful process evaluation in care homes (2021)
Journal Article
Allen, F., Darby, J., Cook, M., Evley, R., Godfrey, M., Horne, J., …Robinson, K. (2021). Learning from a successful process evaluation in care homes. Age and Ageing, 50(5), 1850-1853. https://doi.org/10.1093/ageing/afab139

Introduction process evaluations (PE) are increasingly used in parallel with randomised controlled trials (RCT) to inform the implementation of complex health interventions. This paper explores the learning accrued from conducting a PE within the Fa... Read More about Learning from a successful process evaluation in care homes.

Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis (2021)
Journal Article
Ting, D. S. J., Henein, C., Said, D. G., & Dua, H. S. (2021). Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis. Scientific Reports, 11, Article 13007. https://doi.org/10.1038/s41598-021-92366-x

Infectious keratitis (IK) is the 5th leading cause of blindness globally. Broad-spectrum topical antimicrobial treatment is the current mainstay of treatment for IK, though adjuvant treatment or surgeries are often required in refractory cases of IK.... Read More about Amniotic membrane transplantation for infectious keratitis: a systematic review and meta-analysis.

Cognitive measures used in adults with multiple sclerosis: A systematic review (2021)
Journal Article
Elwick, H., Topcu, G., Allen, C. M., Drummond, A., Evangelou, N., & Das Nair, R. (2022). Cognitive measures used in adults with multiple sclerosis: A systematic review. Neuropsychological Rehabilitation, 32(9), 2464-2481. https://doi.org/10.1080/09602011.2021.1936080

Cognitive problems are common in people with Multiple Sclerosis (MS), and researchers and clinicians have used a vast array of measures to assess cognition. Our aim was to systematically identify cognitive measures routinely used in MS research, and... Read More about Cognitive measures used in adults with multiple sclerosis: A systematic review.

Effects of Pharyngeal Electrical Stimulation on Swallow Timings, Clearance and Safety in Post-Stroke Dysphagia: Analysis from the Swallowing Treatment Using Electrical Pharyngeal Stimulation (STEPS) Trial (2021)
Journal Article
Everton, L. F., Benfield, J. K., Michou, E., Hamdy, S., & Bath, P. M. (2021). Effects of Pharyngeal Electrical Stimulation on Swallow Timings, Clearance and Safety in Post-Stroke Dysphagia: Analysis from the Swallowing Treatment Using Electrical Pharyngeal Stimulation (STEPS) Trial. Stroke Research and Treatment, 2021, Article 5520657. https://doi.org/10.1155/2021/5520657

Swallowing impairment (dysphagia) post-stroke results in poorer outcomes. Pharyngeal electrical stimulation (PES) is a potential treatment for post-stroke dysphagia. In a post hoc analysis, we investigated PES using videofluoroscopy swallow studies (... Read More about Effects of Pharyngeal Electrical Stimulation on Swallow Timings, Clearance and Safety in Post-Stroke Dysphagia: Analysis from the Swallowing Treatment Using Electrical Pharyngeal Stimulation (STEPS) Trial.

Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far? (2021)
Journal Article
Chappell, M. A., McConnell, F. A. K., Golay, X., Günther, M., Hernandez-Tamames, J. A., van Osch, M. J., & Asllani, I. (2021). Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far?. NeuroImage, 238, Article 118236. https://doi.org/10.1016/j.neuroimage.2021.118236

The mismatch in the spatial resolution of Arterial Spin Labeling (ASL) MRI perfusion images and the anatomy of functionally distinct tissues in the brain leads to a partial volume effect (PVE), which in turn confounds the estimation of perfusion into... Read More about Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far?.