All Outputs (129)

Consensus Practice Parameter: Audiological Assessment and Management of Unilateral Hearing Loss in Children (2019)
Journal Article

Objective: Provide recommendations to audiologists for the management of children with unilateral hearing loss (UHL) and for needed research that can lend further insight on important unanswered questions. Design: An international panel of experts... Read More about Consensus Practice Parameter: Audiological Assessment and Management of Unilateral Hearing Loss in Children.

In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles (2019)
Journal Article

Aims To describe the in vivo confocal microscopy (IVCM) features of human limbal nerve corpuscles (LNCs) and correlate these with the histological features. Methods We examined 40 eyes of 29 healthy living subjects (17 female, 12 male; mean age=47... Read More about In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles.

Robust estimation of quantitative perfusion from multi?phase pseudo?continuous arterial spin labeling (2019)
Journal Article

Purpose Multi‐phase PCASL has been proposed as a means to achieve accurate perfusion quantification that is robust to imperfect shim in the labeling plane. However, there exists a bias in the estimation process that is a function of noise in the dat... Read More about Robust estimation of quantitative perfusion from multi?phase pseudo?continuous arterial spin labeling.

Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis (2019)
Journal Article

© 2019 American Medical Association. All rights reserved. Importance: The central vein sign has been proposed as a specific imaging biomarker for distinguishing between multiple sclerosis (MS) and not MS, mainly based on findings from ultrahigh-field... Read More about Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis.

The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm (2019)
Journal Article

© The Author(s) 2019. Objective: To establish feasibility of initiating electrical stimulation treatment of wrist extensors and flexors in patients early after stroke to prevent muscle contractures and pain. Design: Feasibility randomized controlled... Read More about The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm.

Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936 (2019)
Journal Article

Hearing impairment is associated with poorer cognitive function in later life. We tested for the potential contribution of childhood cognitive ability to this relationship. Childhood cognitive ability is strongly related to cognitive function in olde... Read More about Longitudinal associations between hearing loss and general cognitive ability: the Lothian Birth Cohort 1936.

Photoactivated chromophore for infectious keratitis – Corneal cross-linking (PACK-CXL): A systematic review and meta-analysis (2019)
Journal Article

Why Is There No Cure for Tinnitus? (2019)
Journal Article

Tinnitus is unusual for such a common symptom in that there are few treatment options and those that are available are aimed at reducing the impact rather than specifically addressing the tinnitus percept. In particular, there is no drug recommended... Read More about Why Is There No Cure for Tinnitus?.

Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus (2019)
Journal Article

This Cochrane Corner features “Sound therapy (using amplification devices or sound generators) for tinnitus” published in 2018. Sereda et al. identified eight clinical trials including 590 participants receiving sound therapy for tinnitus. None of th... Read More about Cochrane corner: Sound therapy (using amplification devices and/or sound generators) for tinnitus.

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids (2019)
Journal Article

Internet-Based Interventions for Adults With Hearing Loss, Tinnitus, and Vestibular Disorders: A Systematic Review and Meta-Analysis (2019)
Journal Article

Internet-based interventions have been developed to improve access to audiovestibular health care. This review aimed to identify outcomes of Internet interventions for adults with hearing loss, tinnitus, and vestibular disorders. Electronic databases... Read More about Internet-Based Interventions for Adults With Hearing Loss, Tinnitus, and Vestibular Disorders: A Systematic Review and Meta-Analysis.

Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS (2019)
Journal Article

Evidence using well-established imaging techniques, such as functional magnetic resonance imaging and electrocorticography, suggest that speech-specific cortical responses can be functionally localised by contrasting speech responses with an auditory... Read More about Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS.

Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality (2019)
Journal Article

© 2019 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. Background and purpose: We aimed to determine the burden of comorbidities at the time of diagnosis of multiple sclerosi... Read More about Comorbidity in multiple sclerosis: its temporal relationships with disease onset and dose effect on mortality.

Joint modelling of diffusion MRI and microscopy (2019)
Journal Article

The combination of diffusion MRI (dMRI) with microscopy provides unique opportunities to study microstructural features of tissue, particularly when acquired in the same sample. Microscopy is frequently used to validate dMRI microstructure models, ad... Read More about Joint modelling of diffusion MRI and microscopy.

Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant (2019)
Journal Article

Background The genetic basis of monocular elevation deficiency (MED) is unclear. It has previously been considered to arise due to a supranuclear abnormality. Methods Two brothers with MED were referred to Leicester Royal Infirmary, UK from the lo... Read More about Congenital monocular elevation deficiency associated with a novel TUBB3 gene variant.

Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain (2019)
Journal Article

BACKGROUND AND OBJECTIVE: In hyperacute ischaemic stroke, T2 of cerebral water increases with time. Quantifying this change may be informative of the extent of tissue damage and onset time. Our objective was to develop a user-unbiased method to measu... Read More about Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain.

Preoperative brain imaging using functional near-infrared spectroscopy helps predict cochlear implant outcome in deaf adults (2019)
Journal Article

Currently it is not possible to accurately predict how well a deaf individual will be able to understand speech when hearing is (re)introduced via a cochlear implant. Differences in brain organisation following deafness are thought to contribute to v... Read More about Preoperative brain imaging using functional near-infrared spectroscopy helps predict cochlear implant outcome in deaf adults.

Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial (2019)
Journal Article

Background Cilostazol and isosorbide mononitrate (ISMN) are candidate treatments for cerebral small vessel disease and lacunar ischaemic stroke. As both drugs may influence haemoglobin and platelet count, and haemodynamics, we sought to assess their... Read More about Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial.

ICA-based denoising for ASL perfusion imaging (2019)
Journal Article

Arterial Spin Labelling (ASL) imaging derives a perfusion image by tracing the accumulation of magnetically labeled blood water in the brain. As the image generated has an intrinsically low signal to noise ratio (SNR), multiple measurements are routi... Read More about ICA-based denoising for ASL perfusion imaging.

Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT (2019)
Journal Article

BACKGROUND: Tranexamic acid reduces death due to bleeding after trauma and postpartum haemorrhage. OBJECTIVE: The aim of the study was to assess if tranexamic acid is safe, reduces haematoma expansion and improves outcomes in adults with spontaneous... Read More about Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT.