Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS

Mushtaq, Faizah; Wiggins, Ian M.; Kitterick, Pádraig T.; Anderson, Carly A.; Hartley, Douglas E. H.

Abstract

Evidence using well-established imaging techniques, such as functional magnetic resonance imaging and electrocorticography, suggest that speech-specific cortical responses can be functionally localised by contrasting speech responses with an auditory baseline stimulus, such as time-reversed (TR) speech or signal-correlated noise (SCN). Furthermore, these studies suggest that SCN is a more effective baseline than TR speech. Functional near-infrared spectroscopy (fNIRS) is a relatively novel, optically-based imaging technique with features that make it ideal for investigating speech and language function in paediatric populations. However, it is not known which baseline is best at isolating speech activation when imaging using fNIRS. We presented normal speech, TR speech and SCN in an event-related format to 25 normally-hearing children aged 6–12 years. Brain activity was measured across frontal and temporal brain areas in both cerebral hemispheres whilst children passively listened to the auditory stimuli. In all three conditions, significant activation was observed bilaterally in channels targeting superior temporal regions when stimuli were contrasted against silence. Unlike previous findings in infants, we found no significant activation in the region of interest over superior temporal cortex in school-age children when normal speech was contrasted against either TR speech or SCN. Although no statistically significant lateralisation effects were observed in the region of interest, a left-sided channel targeting posterior temporal regions showed significant activity in response to normal speech only, and was investigated further. Significantly greater activation was observed in this left posterior channel compared to the corresponding channel on the right side under the normal speech vs SCN contrast only. Our findings suggest that neither TR speech nor SCN are suitable auditory baselines for functionally isolating speech-specific processing in an experimental set up involving fNIRS with 6–12 year old children.

Citation

Mushtaq, F., Wiggins, I. M., Kitterick, P. T., Anderson, C. A., & Hartley, D. E. H. (2019). Evaluating time-reversed speech and signal-correlated noise as auditory baselines for isolating speech-specific processing using fNIRS. PLoS ONE, 14(7), Article e0219927. https://doi.org/10.1371/journal.pone.0219927

• Journal Article Type: Article
• Acceptance Date: Jul 3, 2019
• Online Publication Date: Jul 17, 2019
• Publication Date: Jul 17, 2019
• Deposit Date: Jul 31, 2019
• Publicly Available Date: Aug 5, 2019
• Journal: PLoS ONE
• Electronic ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 14
• Issue: 7
• Article Number: e0219927
• DOI: https://doi.org/10.1371/journal.pone.0219927
• Keywords: General biochemistry, Genetics and molecular biology; General agricultural and Biological sciences; General medicine
• Public URL: https://nottingham-repository.worktribe.com/output/2363115
• Publisher URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219927
• Contract Date: Jul 31, 2019