All Outputs (1122)

Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future (2020)
Journal Article
Mok, V. C., Pendlebury, S., Wong, A., Alladi, S., Au, L., Bath, P., …Scheltens, P. (2020). Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future. Alzheimer's and Dementia, 16(11), 1571-1581. https://doi.org/10.1002/alz.12143

We have provided an overview on the profound impact of COVID‐19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health‐care settings, including hospital, out‐pat... Read More about Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future.

Maintenance Intravenous Immunoglobulin Treatment for Multiple Sclerosis Coexisting with Ehlers-Danlos Syndrome and Muir-Torre Syndrome: A Case Study (2020)
Journal Article
Gupta, S., Suri, M., & Constantinescu, C. S. (2020). Maintenance Intravenous Immunoglobulin Treatment for Multiple Sclerosis Coexisting with Ehlers-Danlos Syndrome and Muir-Torre Syndrome: A Case Study. Neurology and Therapy, 9(2), 605–610. https://doi.org/10.1007/s40120-020-00209-0

The therapeutic options for disease modification in relapsing-remitting multiple sclerosis (RRMS) have expanded remarkably in the last 15 years. Although intravenous immunoglobulins (IVIg) have shown some therapeutic effects in multiple sclerosis, re... Read More about Maintenance Intravenous Immunoglobulin Treatment for Multiple Sclerosis Coexisting with Ehlers-Danlos Syndrome and Muir-Torre Syndrome: A Case Study.

Seasonal weight changes in laboratory ferrets (2020)
Journal Article
Jones, E. J., Poole, K. C., Sollini, J., Town, S. M., & Bizley, J. K. (2020). Seasonal weight changes in laboratory ferrets. PLoS ONE, 15(8), https://doi.org/10.1371/journal.pone.0232733

Ferrets (Mustela putorius furo) are a valuable animal model used in biomedical research. Like many animals, ferrets undergo significant variation in body weight seasonally, affected by photoperiod, and these variations complicate the use weight as an... Read More about Seasonal weight changes in laboratory ferrets.

Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study (2020)
Journal Article
Maidment, D., Heyes, R., Gomez, R., Coulson, N. S., Wharrad, H., & Ferguson, M. A. (2020). Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study. JMIR mHealth and uHealth, 8(8), https://doi.org/10.2196/17193

© David W Maidment, Rachel Heyes, Rachel Gomez, Neil S Coulson, Heather Wharrad, Melanie A Ferguson. Background: Adults living with hearing loss have highly variable knowledge of hearing aids, resulting in suboptimal use or nonuse. This issue can be... Read More about Evaluating a theoretically informed and co-created mHealth educational intervention for first-time hearing aid users: a qualitative interview study.

Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus (2020)
Journal Article
Hockley, A., Berger, J. I., Palmer, A. R., & Wallace, M. N. (2020). Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus. European Journal of Neuroscience, 52(9), 4057-4080. https://doi.org/10.1111/ejn.14913

Previous work has led to the hypothesis that, during the production of noise?induced tinnitus, higher levels of nitric oxide (NO), in the ventral cochlear nucleus (VCN), increase the gain applied to a reduced input from the cochlea. To test this hypo... Read More about Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus.

Association between Hyperacusis and Tinnitus (2020)
Journal Article
Cederroth, C. R., Lugo, A., Edvall, N. K., Lazar, A., Lopez-Escamez, J., Bulla, J., …Gallus, S. (2020). Association between Hyperacusis and Tinnitus. Journal of Clinical Medicine, 9(8), Article 2412. https://doi.org/10.3390/jcm9082412

Many individuals with tinnitus report experiencing hyperacusis (enhanced sensitivity to sounds). However, estimates of the association between hyperacusis and tinnitus is lacking. Here, we investigate this relationship in a Swedish study. A total of... Read More about Association between Hyperacusis and Tinnitus.

Involving the person with dementia in crisis planning: Focus groups with crisis intervention teams (2020)
Journal Article
Bosco, A., Schneider, J., Di Lorito, C., Broome, E., Coleston-Shields, D. M., & Orrell, M. (2020). Involving the person with dementia in crisis planning: Focus groups with crisis intervention teams. International Journal of Environmental Research and Public Health, 17(15), https://doi.org/10.3390/ijerph17155412

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dementia leads to progressive critical situations that can escalate to a crisis episode if not adequately managed. A crisis may also resolve spontaneously, or not resolve after receiving profe... Read More about Involving the person with dementia in crisis planning: Focus groups with crisis intervention teams.

Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era (2020)
Journal Article
Lawrence, R. J., O'Donoghue, G., Kitterick, P., O'Donoghue, K., Hague, R., Mitchell, L., …Hartley, D. E. (2020). Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era. Laryngoscope, 130(11), 2693-2699. https://doi.org/10.1002/lary.29014

© 2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA) Objectives/Hypothesis: The overall aim of this study was to evaluate personal protective equipment (PPE)... Read More about Recommended Personal Protective Equipment for Cochlear Implant and Other Mastoid Surgery During the COVID-19 Era.

Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study (2020)
Journal Article
Safavi, S., Arthofer, C., Cooper, A., Harkin, J. W., Prayle, A. P., Sovani, M. P., …Hall, I. P. (2020). Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study. European Journal of Radiology, 130, Article 109196. https://doi.org/10.1016/j.ejrad.2020.109196

Purpose The diaphragm is the most important muscle of respiration. Disorders of the diaphragm can have a deleterious impact on respiratory function. We aimed to evaluate the use of an open-configuration upright low-field MRI system to assess diaphra... Read More about Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study.

Exploring tinnitus heterogeneity (2020)
Book Chapter
Beukes, E. W., Manchaiah, V., Allen, P. M., Andersson, G., & Baguley, D. M. (2021). Exploring tinnitus heterogeneity. In Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: From Heterogeneity to Personalized Medicine (79-99). Elsevier. https://doi.org/10.1016/bs.pbr.2020.05.022

Introduction: Tinnitus experiences differ widely. A greater understanding of the core processes underlying these variations is needed. Moreover, meaningful definitions for different subgroups are required to better manage this heterogeneous populatio... Read More about Exploring tinnitus heterogeneity.

A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF) (2020)
Journal Article
Gillies, M., Ghaffar, S., Moppett, I., Docherty, A., Clarke, S., Rea, N., …Walsh, T. (2021). A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF). British Journal of Anaesthesia, 126(1), 77-86. https://doi.org/10.1016/j.bja.2020.06.048

Background The optimum transfusion strategy in patients with fractured neck of femur is uncertain, particularly if there is coexisting cardiovascular disease. Methods We conducted a prospective, single-centre, randomised feasibility trial of tw... Read More about A restrictive versus liberal transfusion strategy to prevent myocardial injury in patients undergoing surgery for fractured neck of femur: a feasibility randomised trial (RESULT-NOF).

Increased IL-2 and reduced tgf-? upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis (2020)
Journal Article
Aram, J., Frakich, N., Morandi, E., Alrouji, M., Samaraweera, A., Onion, D., …Constantinescu, C. S. (2020). Increased IL-2 and reduced tgf-β upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis. Biomedicines, 8(7), https://doi.org/10.3390/BIOMEDICINES8070226

© 2020 by the authors. Granulocyte macrophage colony stimulating factor (GM-CSF) is a pro-inflammatory cytokine produced by immune cells. Recent evidence suggests that GM-CSF plays an important role in multiple sclerosis (MS) pathogenesis. We investi... Read More about Increased IL-2 and reduced tgf-? upon t-cell stimulation are associated with GM-CSF upregulation in multiple immune cell types in multiple sclerosis.

The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus (2020)
Journal Article
Taylor, J. A., Thompson, D. M., Hall, D. A., Walker, D., McMurran, M., Casey, A., …Hoare, D. J. (2020). The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus. International Journal of Audiology, 59(12), 905-914. https://doi.org/10.1080/14992027.2020.1788730

Objective: To develop a manualised psychological treatment for tinnitus that could enhance audiologist usual care, and to test feasibility of evaluating it in a randomised controlled trial. Design: Feasibility trial, random allocation of patients to... Read More about The TinMan study: feasibility trial of a psychologically informed, audiologist-delivered, manualised intervention for tinnitus.

Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations (2020)
Journal Article
Morris, B., Curtin, L., Hawkins-Daarud, A., Hubbard, M. E., Rahman, R., Smith, S. J., …Owen, M. R. (2020). Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations. Mathematical Biosciences and Engineering, 17(5), 4905-4941. https://doi.org/10.3934/mbe.2020267

Glioblastomas (GBMs) are the most aggressive primary brain tumours and have no known cure. Each individual tumour comprises multiple sub-populations of genetically-distinct cells that may respond differently to targeted therapies and may contribute t... Read More about Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations.

Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial (2020)
Journal Article
Evans, S. R., Knutsson, M., Amarenco, P., Albers, G. W., Bath, P. M., Denison, H., …Johnston, S. C. (2020). Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial. Clinical Trials, 17(6), 617-626. https://doi.org/10.1177/1740774520941441

Background/Aims: Standard approaches to trial design and analyses can be inefficient and non-pragmatic. Failure to consider a range of outcomes impedes evidence-based interpretation and reduces power. Traditional approaches synthesizing information o... Read More about Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial.

An Exploratory Study of EEG Alpha Oscillation and Pupil Dilation in Hearing-Aid Users During Effortful listening to Continuous Speech (2020)
Journal Article
Seifi Ala, T., Graversen, C., Wendt, D., Alickovic, E., Whitmer, W. M., & Lunner, T. (2020). An Exploratory Study of EEG Alpha Oscillation and Pupil Dilation in Hearing-Aid Users During Effortful listening to Continuous Speech. PLoS ONE, 15(7), Article e0235782. https://doi.org/10.1371/journal.pone.0235782

Individuals with hearing loss allocate cognitive resources to comprehend noisy speech in everyday life scenarios. Such a scenario could be when they are exposed to ongoing speech and need to sustain their attention for a rather long period of time, w... Read More about An Exploratory Study of EEG Alpha Oscillation and Pupil Dilation in Hearing-Aid Users During Effortful listening to Continuous Speech.

Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis (2020)
Journal Article
McHutchison, C., Blair, G. W., Appleton, J. P., Chappell, F. M., Doubal, F., Bath, P. M., & Wardlaw, J. M. (2020). Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis. Stroke, 51(8), 2374-2385. https://doi.org/10.1161/strokeaha.120.029454

Background and Purpose: Cilostazol, a phosphodiesterase 3’ inhibitor, is used in Asia-Pacific countries for stroke prevention, but rarely used elsewhere. In addition to weak antiplatelet effects, it stabilises endothelium, aids myelin repair and astr... Read More about Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis.

Cost-benefit of outcome adjudication in nine randomised stroke trials (2020)
Journal Article
Godolphin, P. J., Bath, P. M., Algra, A., Berge, E., Chalmers, J., Eliasziw, M., …Montgomery, A. A. (2020). Cost-benefit of outcome adjudication in nine randomised stroke trials. Clinical Trials, 17(5), 576-580. https://doi.org/10.1177/1740774520939231

Background: Central adjudication of outcomes is common for randomised trials and should control for differential misclassification. However, few studies have estimated the cost of the adjudication process. Methods: We estimated the cost of adjudicat... Read More about Cost-benefit of outcome adjudication in nine randomised stroke trials.

Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND) (2020)
Journal Article
Morriss, R., Webster, L., Abdelghani, M., Auer, D., Barber, S., Bates, P., …Walters, Y. (2020). Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND). BMJ Open, 10(7), Article e038430. https://doi.org/10.1136/bmjopen-2020-038430

Introduction The BRIGhTMIND study aims to determine the clinical effectiveness, cost effectiveness and mechanism of action of connectivity guided intermittent Theta Burst Stimulation (cgiTBS) versus standard repetitive Transcranial Magnetic Stimulati... Read More about Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND).

A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging (2020)
Journal Article
Tournier, J., Christiaens, D., Hutter, J., Price, A. N., Cordero-Grande, L., Hughes, E., …Hajnal, J. V. (2020). A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging. NMR in Biomedicine, 33(9), Article e4348. https://doi.org/10.1101/661348

Diffusion MRI has the potential to provide important information about the connectivity and microstructure of the human brain during normal and abnormal development, non-invasively and in vivo. Recent developments in MRI hardware and reconstruction m... Read More about A data-driven approach to optimising the encoding for multi-shell diffusion MRI with application to neonatal imaging.