All Outputs (36)

Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis (2015)
Journal Article

Rationale: Pulmonary infection and malnutrition in cystic fibrosis are associated with decreased survival. Glutamine has a possible anti-microbial effect, with a specific impact against Pseudomonas aeruginosa. We aimed to test the hypothesis that ora... Read More about Glutamine supplementation in cystic fibrosis: A randomized placebo-controlled trial: Oral Glutamine Supplementation in Cystic Fibrosis.

Monotherapy or polytherapy for childhood epilepsies? (2015)
Journal Article

Cycling infrastructure for reducing cycling injuries in cyclists (2015)
Journal Article

Background: Cycling is an attractive form of transport. It is beneficial to the individual as a form of physical activity that may fit more readily into an individual’s daily routine, such as for cycling to work and to the shops, than other physical... Read More about Cycling infrastructure for reducing cycling injuries in cyclists.

Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year (2015)
Journal Article

Pre-eclampsia leads to disturbed fetal organ development, including metabolic syndrome, attributed to altered pituitary-adrenal feedback loop. We measured cortisol metabolites in infants born from pre-eclamptic and normotensive women and hypothesised... Read More about Born from pre-eclamptic pregnancies predisposes infants to altered cortisol metabolism in the first postnatal year.

Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line (2015)
Journal Article

During the first trimester, normal placental development occurs in a low oxygen environment that is known to stimulate angiogenesis via upregulation of vascular endothelial growth factor (VEGF). Expression of the placental renin-angiotensin system (R... Read More about Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line.

Use of biochemical tests of placental function for improving pregnancy outcome (2015)
Journal Article

BACKGROUND: The placenta has an essential role in determining the outcome of pregnancy. Consequently, biochemical measurement of placentally-derived factors has been suggested as a means to improve fetal and maternal outcome of pregnancy. OBJ... Read More about Use of biochemical tests of placental function for improving pregnancy outcome.

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis (2015)
Journal Article

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeru... Read More about Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis.

Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial (2015)
Journal Article

Background Preterm pre-labour ruptured membranes close to term is associated with increased risk of neonatal infection, but immediate delivery is associated with risks of prematurity. The balance of risks is unclear. We aimed to establish whether... Read More about Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial.

Maternal outcomes at 3 months after planned caesarean section versus planned vaginal birth for twin pregnancies in the Twin Birth Study: a randomised controlled trial (2015)
Journal Article

OBJECTIVE: To compare outcomes at 3 months post partum for women randomised to give birth by planned caesarean section (CS) or by planned vaginal birth (VB) in the Twin Birth Study (TBS). DESIGN: We invited women in the TBS to complete a 3-month f... Read More about Maternal outcomes at 3 months after planned caesarean section versus planned vaginal birth for twin pregnancies in the Twin Birth Study: a randomised controlled trial.

Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes (2015)
Journal Article

Context: Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse neonatal outcomes. The extent to which this may be mediated by differences in placental metabolism and nutrient transport remains to be determined.... Read More about Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes.

The obstetric care of asylum seekers and refugee women in the UK (2015)
Journal Article

Asylum seekers and refugees are a vulnerable group with regards to pregnancy outcomes and accessing maternity care. Asylum seekers and refugees who are pregnant and living in the UK face medical, sexual and psychosocial challenges, including dispersa... Read More about The obstetric care of asylum seekers and refugee women in the UK.

Pre-translational regulation of luteinizing hormone receptor in follicular somatic cells of cattle (2015)
Journal Article

Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum (2015)
Journal Article

Background: Normal pregnancy depends on pronounced adaptations in steroid hormone concentrations. Although in recent years, the understanding of these hormones in pregnancy has improved, the interpretation is hampered by insufficient reference values... Read More about Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum.

Cystic fibrosis microbiology: advances in antimicrobial therapy (2015)
Journal Article

Much of the improvement in the survival of individuals with cystic fibrosis (CF) is due to advancements in antimicrobial treatments. New aerosolized antibiotic formulations have recently been introduced (such as inhaled aztreonam), and others are in... Read More about Cystic fibrosis microbiology: advances in antimicrobial therapy.

The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison (2015)
Journal Article

Background: Circadian variation in renal toxicity of aminoglycosides has been demonstrated in animal and human studies. People with CF are frequently prescribed aminoglycosides. Altered pharmacokinetics of aminoglycosides are predictive of toxicity.... Read More about The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison.

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015)
Journal Article

BACKGROUND: Cystic fibrosis is a multi-system disease characterised by the production of thick secretions causing recurrent pulmonary infection, often with unusual bacteria. Intravenous antibiotics are commonly used in the treatment of acute deterior... Read More about Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis.

Maternal and neonatal outcomes in pregnant women with PCOS: comparison of different diagnostic definitions (2015)
Journal Article

A clinically useful simplified blastocyst grading system (2015)
Journal Article

Maternal dexamethasone treatment alters tissue and circulating components of the renin-angiotensin system in the pregnant ewe and fetus (2015)
Journal Article

Antenatal synthetic glucocorticoids promote fetal maturation in pregnant women at risk of preterm delivery and their mechanism of action may involve other endocrine systems. This study investigated the effect of maternal dexamethasone treatment, at c... Read More about Maternal dexamethasone treatment alters tissue and circulating components of the renin-angiotensin system in the pregnant ewe and fetus.

Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response (2015)
Journal Article

Aims: Recent studies have observed that cells from high-grade glial tumors are capable of assuming an endothelial phenotype and genotype, a process termed ‘vasculogenic mimicry’ (VM). Here we model and manipulate VM in dynamic 3-dimensional (3D) glio... Read More about Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response.