All Outputs (11)

Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI (2020)
Journal Article
Iwabuchi, S. J., Xing, Y., Cottam, W. J., Drabek, M. M., Tadjibaev, A., Fernandes, G. S., …Auer, D. P. (2020). Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI. PAIN, 161(6), 1255-1263. https://doi.org/10.1097/j.pain.0000000000001829

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pain pathways are associated with pain chronicity, for example, in postoperative pain after knee replacement. Other factors such as low mood,... Read More about Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI.

Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis (2019)
Journal Article
Georgopoulos, V., Akin-Akinyosoye, K., Zhang, W., McWilliams, D. F., Hendrick, P., & Walsh, D. A. (2019). Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis. PAIN, 160(9), 1920-1932. https://doi.org/10.1097/j.pain.0000000000001590

Hypersensitivity due to central pain mechanisms can influence recovery and lead to worse clinical outcomes, but the ability of quantitative sensory testing (QST), an index of sensitisation, to predict outcomes in chronic musculoskeletal disorders rem... Read More about Quantitative sensory testing and predicting outcomes for musculoskeletal pain, disability, and negative affect: a systematic review and meta-analysis.

Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort (2018)
Journal Article
Akin-Akinyosoye, K., Frowd, N., Marshall, L., Stocks, J., Fernandes, G. S., Valdes, A. M., …Walsh, D. A. (2018). Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort. PAIN, 159(6), 1035–1044. https://doi.org/10.1097/j.pain.0000000000001183

This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain thres... Read More about Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort.

Proportion of contextual effects in the treatment of fibromyalgia - a meta-analysis of randomised controlled trials (2017)
Journal Article
Whiteside, N., Sarmanova, A., Chen, X., Zou, K., Abdullah, N., Doherty, M., & Zhang, W. (in press). Proportion of contextual effects in the treatment of fibromyalgia - a meta-analysis of randomised controlled trials. Clinical Rheumatology, https://doi.org/10.1007/s10067-017-3948-3

Objectives: To examine the proportion of the total treatment effect that is attributable to contextual effects in randomised controlled trials (RCTs) of treatments for fibromyalgia. Methods: A systematic literature search was undertaken in Medline,... Read More about Proportion of contextual effects in the treatment of fibromyalgia - a meta-analysis of randomised controlled trials.

Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis (2017)
Journal Article
Valdes, A. M., Abhishek, A., Muir, K., Zhang, W., Maciewicz, R. A., & Doherty, M. (2017). Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis. Arthritis Care and Research, 69(7), 1076-1081. https://doi.org/10.1002/acr.23091

Objective: Recent findings suggest that β-adrenergic blockers have anti-nociceptive properties. The aim of this study was to compare levels of large joint pain between those on adrenergic blockers and those on other antihypertensive medications. Met... Read More about Association of beta-blocker use with less prevalent joint pain and lower opioid requirement in people with osteoarthritis.

Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene (2017)
Journal Article
Warner, S., Walsh, D. A., Laslett, L., Maciewicz, R., Soni, A., Hart, D., …Valdes, A. M. (2017). Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene. European Journal of Pain, 21(7), 1277-1284. https://doi.org/10.1002/ejp.1027

Background: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1). SP and NK1 receptors have been implicated in joint pain, inflammation and damage in animal models and human s... Read More about Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR 1) gene.

The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis (2017)
Journal Article
Morandi, E., Tanasescu, R., Tarlinton, R. E., Constantinescu, C. S., Zhang, W., Tench, C. R., & Gran, B. (2017). The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis. PLoS ONE, 12(2), Article e0172415. https://doi.org/10.1371/journal.pone.0172415

Background: The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.... Read More about The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis.

Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study (2017)
Journal Article
Kuo, C. F., Grainge, M. J., Valdes, A. M., See, L. C., Yu, K. H., Steven Shaw, S. W., …Doherty, M. (2017). Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study. Rheumatology, 56(6), 928-933. https://doi.org/10.1093/rheumatology/kew500

© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. Objective. The aim was to estimate familial relative risk (RR) for RA and other autoimmune diseases and the genetic contri... Read More about Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study.

Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis (2016)
Journal Article
Persson, M. S., Fu, Y., Bhattacharya, A., Goh, S., Middelkoop, M. V., Bierma-Zeinstra, S. M., …Zhang, W. (2016). Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis. Systematic Reviews, 5(1), Article 165. https://doi.org/10.1186/s13643-016-0348-8

Background Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatme... Read More about Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis.

Relative efficacy of different types of exercise for treatment of knee and hip osteoarthritis: Protocol for network meta-analysis of randomised controlled trials (2016)
Journal Article
Goh, S., Persson, M., Bhattacharya, A., Hall, M. C., Doherty, M., & Zhang, W. (2016). Relative efficacy of different types of exercise for treatment of knee and hip osteoarthritis: Protocol for network meta-analysis of randomised controlled trials. Systematic Reviews, 5(147), https://doi.org/10.1186/s13643-016-0321-6

Background: “Exercise” is universally recommended as a core treatment for knee and hip osteoarthritis (OA). However, there are very few head-to-head comparative trials to determine the relative efficacy between different types of exercise. The aim of... Read More about Relative efficacy of different types of exercise for treatment of knee and hip osteoarthritis: Protocol for network meta-analysis of randomised controlled trials.

Chondrocalcinosis is common in the absence of knee involvement (2012)
Journal Article
Abhishek, A., Doherty, S., Maciewicz, R., Muir, K., Zhang, W., & Doherty, M. (2012). Chondrocalcinosis is common in the absence of knee involvement. Arthritis Research and Therapy, 14(5), Article 5. https://doi.org/10.1186/ar4043

Introduction: We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee involvement. Methods: This was... Read More about Chondrocalcinosis is common in the absence of knee involvement.