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Micronutrient and amino acid losses in acute renal replacement therapy (2015)
Journal Article
Oh, W. C., Gardner, D. S., & Devonald, M. A. (2015). Micronutrient and amino acid losses in acute renal replacement therapy. Current Opinion in Clinical Nutrition and Metabolic Care, 18(6), 593-598. https://doi.org/10.1097/MCO.0000000000000220

A wide range of renal replacement therapies is now available to support patients with acute kidney injury. These treatments utilize diffusion, convection or a combination of these mechanisms to remove metabolic waste products from the bloodstream. It... Read More about Micronutrient and amino acid losses in acute renal replacement therapy.

Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform (2015)
Journal Article
Denning, C., Borgdorff, V., Crutchley, J., Firth, K. S., George, V., Kalra, S., …Young, L. E. (2016). Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform. BBA - Biochimica et Biophysica Acta, 1863(7), https://doi.org/10.1016/j.bbamcr.2015.10.014

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise biomedicine. Global burden of heart failure will soon reach USD $90bn, while unexpected cardiotoxicity underlies 28% of drug withdrawals. Advances in hPSC isolation, Cas... Read More about Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform.

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma (2015)
Journal Article
Lilburn, D. M., Tatler, A. L., Six, J. S., Lesbats, C., Habgood, A., Porte, J., …Meersmann, T. (2015). Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma. Magnetic Resonance in Medicine, 76(4), 1224-1235. https://doi.org/10.1002/mrm.26003

© 2015 The Authors. Wiley Periodicals, Inc. Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independen... Read More about Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.

Measuring macroscopic brain connections in vivo (2015)
Journal Article
Jbabdi, S., Sotiropoulos, S. N., Haber, S. N., Van Essen, D. C., & Behrens, T. E. (2015). Measuring macroscopic brain connections in vivo. Nature Neuroscience, 18(11), https://doi.org/10.1038/nn.4134

Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of de... Read More about Measuring macroscopic brain connections in vivo.

Nottingham Prognostic Index Plus: validation of a clinical decision making tool in breast cancer in an independent series (2015)
Journal Article
Green, A. R., Soria, D., Stephen, J., Powe, D. G., Nolan, C. C., Kunkler, I., Thomas, J., Kerr, G. R., Jack, W., Cameron, D., Piper, T., Ball, G. R., Garibaldi, J. M., Rakha, E., Bartlett, J. M., & Ellis, I. O. (2016). Nottingham Prognostic Index Plus: validation of a clinical decision making tool in breast cancer in an independent series. Journal of Pathology: Clinical Research, 2, https://doi.org/10.1002/cjp2.32

The Nottingham Prognostic Index Plus (NPI+)is a clinical decision making tool in breast cancer (BC) that aims to provide improved patient outcome stratification superior to the traditional NPI. This study aimed to validate the NPI+ in an independent... Read More about Nottingham Prognostic Index Plus: validation of a clinical decision making tool in breast cancer in an independent series.

How does auditory training work? Joined up thinking and listening (2015)
Journal Article
Ferguson, M. A., & Henshaw, H. (in press). How does auditory training work? Joined up thinking and listening. Seminars in Hearing, 36(4), https://doi.org/10.1055/s-0035-1568985

Auditory training aims to compensate for degradation in the auditory signal and is offered as an intervention to help alleviate the most common complaint in people with hearing loss, understanding speech in a background noise. Yet there remain many u... Read More about How does auditory training work? Joined up thinking and listening.

An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging (2015)
Journal Article
Andersson, J. L., & Sotiropoulos, S. N. (2016). An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. NeuroImage, 125, https://doi.org/10.1016/j.neuroimage.2015.10.019

In this paper we describe a method for retrospective estimation and correction of eddy current (EC)-induced distortions and subject movement in diffusion imaging. In addition a susceptibility-induced field can be supplied and will be incorporated int... Read More about An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging.

The feasibility of psychomotor therapy in acute mental health services for adults with intellectual disability (2015)
Journal Article
Kay, J. J., Clegg, J. A., Emck, C., & Standen, P. J. (2016). The feasibility of psychomotor therapy in acute mental health services for adults with intellectual disability. Journal of Intellectual and Developmental Disability, 41(1), 54-60. https://doi.org/10.3109/13668250.2015.1094037

Background. Psychomotor therapy enables people to reflect on the relationship between experiences and feelings by starting from awareness of bodily responses rather than from awareness of emotion. In this study we examine PsyMot (ID), an assessment t... Read More about The feasibility of psychomotor therapy in acute mental health services for adults with intellectual disability.

Hyperacusis Questionnaire as a Tool for Measuring Hypersensitivity to Sound in a Tinnitus Research Population (2015)
Journal Article
Fackrell, K., Fearnley, C., Hoare, D. J., & Sereda, M. (2015). Hyperacusis Questionnaire as a Tool for Measuring Hypersensitivity to Sound in a Tinnitus Research Population. BioMed Research International, 2015, 1-12. https://doi.org/10.1155/2015/290425

Hypersensitivity to external sounds is often comorbid with tinnitus and may be significant for adherence to certain types of tinnitus management. Therefore, a clear measure of sensitivity to sound is important. The aim of this study was to evaluate t... Read More about Hyperacusis Questionnaire as a Tool for Measuring Hypersensitivity to Sound in a Tinnitus Research Population.

Recommendations to facilitate the ideal fit note: are they achievable in practice? (2015)
Journal Article
Coole, C., Nouri, F., Potgieter, I., Watson, P. J., Thomson, L., Hampton, R., & Drummond, A. (2015). Recommendations to facilitate the ideal fit note: are they achievable in practice?. BMC Family Practice, 16(138), Article 138. https://doi.org/10.1186/s12875-015-0360-4

Background: Although the UK fit note has been broadly welcomed as a tool to facilitate return to work, difficulties and uncertainties have resulted in wide variation in its use. Agreement on what constitutes the ‘ideal’ fit note from the perspective... Read More about Recommendations to facilitate the ideal fit note: are they achievable in practice?.

Identification of mechano-sensitive C fibre sensitization and contribution to nerve injury-induced mechanical hyperalgesia (2015)
Journal Article
Hulse, R. P. (2015). Identification of mechano-sensitive C fibre sensitization and contribution to nerve injury-induced mechanical hyperalgesia. European Journal of Pain, 20(4), https://doi.org/10.1002/ejp.779

Background

C fibre hyperexcitability is fundamental to chronic pain development in humans and rodents; therefore, peripheral sensory neuronal sensitization plays a role in the development of mechanical hyperalgesia. However, the axonal properties... Read More about Identification of mechano-sensitive C fibre sensitization and contribution to nerve injury-induced mechanical hyperalgesia.

Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme (2015)
Journal Article
Howard, G., Walker, A. J., Shaw, D. E., & Hatton, J. W. (2015). Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme. Clinical Governance, 20(3), https://doi.org/10.1108/CGIJ-07-2015-0021

Purpose

This paper briefly outlines a development programme designed to improve the skills of NHS Information Analysts and assesses the extent these skills have been developed. There are significant opportunities for the NHS to utilise information... Read More about Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme.

Psychometric properties of the Tinnitus Functional Index (TFI): assessment in a UK research volunteer population (2015)
Journal Article
Fackrell, K. L., Hall, D. A., Barry, J. G., & Hoare, D. J. (2016). Psychometric properties of the Tinnitus Functional Index (TFI): assessment in a UK research volunteer population. Hearing Research, 335, https://doi.org/10.1016/j.heares.2015.09.009

Objectives

Questionnaires are essential for measuring tinnitus severity and intervention-related change but there is no standard instrument used routinely in research settings. Most tinnitus questionnaires are optimised for measuring severity but... Read More about Psychometric properties of the Tinnitus Functional Index (TFI): assessment in a UK research volunteer population.

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts (2015)
Journal Article
Fleming, L., Murray, C., Bansal, A. T., Hashimoto, S., Bisgaard, H., Bush, A., Frey, U., Hedlin, G., Singer, F., Aalderen, W. M. V., Vissing, N. H., Zolkipli, Z., Selby, A., Fowler, S., Shaw, D. E., Chung, K. F., Sousa, A. R., Wagers, S., Corfield, J., Pandis, I., …Roberts, G. (2015). The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts. European Respiratory Journal, 46(5), https://doi.org/10.1183/13993003.00780-2015

U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches.

A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 schoo... Read More about The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

A probabilistic atlas of the cerebellar white matter (2015)
Journal Article
van Baarsen, K., Kleinnijenhuis, M., Jbabdi, S., Sotiropoulos, S., Grotenhuis, J., & van Cappellen van Walsum, A. (2016). A probabilistic atlas of the cerebellar white matter. NeuroImage, 124,Pt(A), https://doi.org/10.1016/j.neuroimage.2015.09.014

Imaging of the cerebellar cortex, deep cerebellar nuclei and their connectivity are gaining attraction, due to the important role the cerebellum plays in cognition and motor control. Atlases of the cerebellar cortex and nuclei are used to locate regi... Read More about A probabilistic atlas of the cerebellar white matter.

Computer and internet interventions to optimize listening and learning for people with hearing loss: accessibility, use, and adherence (2015)
Journal Article
Ferguson, M. A., & Henshaw, H. (2015). Computer and internet interventions to optimize listening and learning for people with hearing loss: accessibility, use, and adherence. American Journal of Audiology, 24, https://doi.org/10.1044/2015_AJA-14-0090

Purpose: The aim of this research forum article was to examine accessibility, use, and adherence to computerized and online interventions for people with hearing loss. Method: Four intervention studies of people with hearing loss were examined: 2 aud... Read More about Computer and internet interventions to optimize listening and learning for people with hearing loss: accessibility, use, and adherence.

A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain (2015)
Journal Article
Doleman, B., Heinink, T., Faleiro, R., Lund, J. N., & Williams, J. P. (2015). A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. Anaesthesia, 70(10), https://doi.org/10.1111/anae.13179

We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until December 2014 and included 133 randomised controlled trials of peri-operative gabapentin vs placebo. Gabapentin reduced mean (95% CI) 24-h morphine-equivalent consumption by 8.44 (... Read More about A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain.

Intrinsic and extrinsic motivation is associated with computer-based auditory training uptake, engagement, and adherence for people with hearing loss (2015)
Journal Article
Henshaw, H., McCormack, A., & Ferguson, M. A. (2015). Intrinsic and extrinsic motivation is associated with computer-based auditory training uptake, engagement, and adherence for people with hearing loss. Frontiers in Psychology, 6, Article 1067. https://doi.org/10.3389/fpsyg.2015.01067

Hearing aid intervention typically occurs after significant delay, or not at all, resulting in an unmet need for many people with hearing loss. Computer-based auditory training (CBAT) may provide generalized benefits to real-world listening, particul... Read More about Intrinsic and extrinsic motivation is associated with computer-based auditory training uptake, engagement, and adherence for people with hearing loss.