All Outputs (91)

TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis (2015)
Journal Article

CD4+CD25hi FOXP3+ regulatory T cells (Tregs) maintain tolerance to self-Ags. Their defective function is involved in the pathogenesis of multiple sclerosis (MS), an inflammatory demyelinating disease of the CNS. However, the mechanisms of such defect... Read More about TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis.

Forming a consensus opinion on exercise prehabilitation in elderly colorectal cancer patients: a Delphi study (2015)
Journal Article

Medical students’ personal experience of high-stakes failure: case studies using interpretative phenomenological analysis (2015)
Journal Article

Background Failing a high-stakes assessment at medical school is a major event for those who go through the experience. Students who fail at medical school may be more likely to struggle in professional practice, therefore helping individuals overco... Read More about Medical students’ personal experience of high-stakes failure: case studies using interpretative phenomenological analysis.

Markers of progression in early-stage invasive breast cancer: a predictive immunohistochemical panel algorithm for distant recurrence risk stratification (2015)
Journal Article

Accurate distant metastasis (DM) prediction is critical for risk stratification and effective treatment decisions in breast cancer (BC). Many prognostic markers/models based on tissue marker studies are continually emerging using conventional statist... Read More about Markers of progression in early-stage invasive breast cancer: a predictive immunohistochemical panel algorithm for distant recurrence risk stratification.

Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure (2015)
Journal Article

© 2015 Elsevier Inc. All rights reserved. Objectives. Weight loss (WL) is associated with a decrease in total and resting energy expenditure (EE). We aimed to investigate whether (1) diets with different rate and extent of WL determined different cha... Read More about Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure.

Childbirth experience questionnaire: validating its use in the United Kingdom (2015)
Journal Article

BACKGROUND: The Childbirth Experience Questionnaire (CEQ) was developed in Sweden in 2010 and validated in 920 primiparous women. It has not been validated in the United Kingdom (UK). Measuring the impact of an intervention on a woman's childbirth e... Read More about Childbirth experience questionnaire: validating its use in the United Kingdom.

A novel method for delivering ramped cooling reveals rat behaviours at innocuous and noxious temperatures: A comparative study of human psychophysics and rat behaviour (2015)
Journal Article

Background Thermal sensory testing in rodents informs human pain research. There are important differences in the methodology for delivering thermal stimuli to humans and rodents. This is particularly true in cold pain research. These differences... Read More about A novel method for delivering ramped cooling reveals rat behaviours at innocuous and noxious temperatures: A comparative study of human psychophysics and rat behaviour.

Prescribing opioid analgesics for chronic non-malignant pain in general practice - a survey of attitudes and practice (2015)
Journal Article

Background: This study replicates a previous postal survey of general practitioners (GPs) to explore whether attitudes to opioid prescribing have changed at a time when the number of opioid prescriptions issued in primary care has increased. Metho... Read More about Prescribing opioid analgesics for chronic non-malignant pain in general practice - a survey of attitudes and practice.

Source space estimation of oscillatory power and brain connectivity in tinnitus (2015)
Journal Article

© 2015 Zobay et al. Tinnitus is the perception of an internally generated sound that is postulated to emerge as a result of structural and functional changes in the brain. However, the precise pathophysiology of tinnitus remains unknown. Llinas' thal... Read More about Source space estimation of oscillatory power and brain connectivity in tinnitus.

Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study. (2015)
Journal Article

© BMJ Publishing Group Ltd 2015. To compare the effectiveness and acceptability of outpatient polypectomy with inpatient polypectomy. Design Pragmatic multicentre randomised controlled noninferiority study. Setting Outpatient hysteroscopy clinics in... Read More about Outpatient versus inpatient uterine polyp treatment for abnormal uterine bleeding: randomised controlled non-inferiority study..

Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data (2015)
Journal Article

The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providin... Read More about Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data.

Psychosocial work environment and leisure-time physical activity: the Stormont Study (2015)
Journal Article

Background: Research findings are equivocal on relations between the psychosocial work environment and leisure-time physical activity (LTPA). This might be partly due to studies having focused on a restricted set of psychosocial dimensions, thereby... Read More about Psychosocial work environment and leisure-time physical activity: the Stormont Study.

Patients' use of a home-based virtual reality system to provide rehabilitation of the upper limb following stroke (2015)
Journal Article

Objective Effectiveness depends on adherence, so did patients use the intervention to the recommended level? If not, what reasons did they give? The purpose of this study was to investigate these and related questions. Design A prospective c... Read More about Patients' use of a home-based virtual reality system to provide rehabilitation of the upper limb following stroke.

Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-?-treated macrophages to pseudomonas aeruginosa infection (2015)
Journal Article

Pseudomonas aeruginosa is an opportunistic pathogen that can cause severe infections at compromised epithelial surfaces, such those found in burns, wounds, and in lungs damaged by mechanical ventilation or recurrent infections, particularly in cystic... Read More about Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-?-treated macrophages to pseudomonas aeruginosa infection.

Investigating gender differences in the factor structure of the Gudjonsson Compliance Scale (2015)
Journal Article

Purpose: The Gudjonsson Compliance Scale (GCS) remains, in terms of its psychometrics, an under-researched instrument, in which gender differences in particular have been insufficiently examined. The aim of this research was to therefore investigate... Read More about Investigating gender differences in the factor structure of the Gudjonsson Compliance Scale.

Health state utility values for diabetic retinopathy: protocol for a systematic review and meta-analysis (2015)
Journal Article

Background People with diabetic retinopathy tend to have lower levels of health-related quality of life than individuals with no retinopathy. Strategies for screening and treatment have been shown to be cost-effective. In order to reduce the bias in... Read More about Health state utility values for diabetic retinopathy: protocol for a systematic review and meta-analysis.

Quantum dot labelling of adenovirus allows for highly sensitive single cell flow and imaging cytometry (2015)
Journal Article

A quantum dot method for highly efficient labelling of single adenoviral particles is developed. The technique has no impact on viral fitness and allows the imaging and tracking of virus binding and internalisation events using a variety of technique... Read More about Quantum dot labelling of adenovirus allows for highly sensitive single cell flow and imaging cytometry.

Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis (2015)
Journal Article

Recent research has demonstrated that infection with the bacterial pathogen Helicobacter pylori is less common amongst patients with multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS). We aimed to compa... Read More about Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis.

The just-noticeable difference in speech-to-noise ratio (2015)
Journal Article

Just-noticeable differences (JNDs) have been measured for various features of sounds, but despite its importance to communication, there is no benchmark for what is a just-noticeable—and possibly meaningful—difference in speech-to-noise ratio (SNR).... Read More about The just-noticeable difference in speech-to-noise ratio.

Evaluating a person-centred chronic pain service using indices of reliable and clinically significant change (2015)
Journal Article

Background: Psychological interventions for chronic pain often require substantial individualisation, which can undermine links with the research evidence on which treatment is based. To ensure patients receive effective therapy, evaluation is needed... Read More about Evaluating a person-centred chronic pain service using indices of reliable and clinically significant change.