All Outputs (47)

A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: implications for palliative care research (2014)
Journal Article

Context. The challenges of palliative care clinical trial recruitment are well documented. Objectives. The aim of the study was to review tested strategies to improve recruitment to trials of people with a range of conditions who may access palliati... Read More about A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: implications for palliative care research.

“You can’t just jump on a bike and go”: a qualitative study exploring parents’ perceptions of physical activity in children with type 1 diabetes (2014)
Journal Article

Background Parents of children with Type 1 Diabetes Mellitus (T1DM) have an important role in supporting diabetes management behaviours and helping to maintain their child’s healthy lifestyle. Physical activity has known benefits for children with... Read More about “You can’t just jump on a bike and go”: a qualitative study exploring parents’ perceptions of physical activity in children with type 1 diabetes.

An overview of the major phenomena of the localization of sound sources by normal-hearing, hearing-impaired, and aided listeners (2014)
Journal Article

Localizing a sound source requires the auditory system to determine its direction and its distance. In general, hearing-impaired listeners do less well in experiments measuring localization performance than normal-hearing listeners, and hearing aids... Read More about An overview of the major phenomena of the localization of sound sources by normal-hearing, hearing-impaired, and aided listeners.

Relationship between tinnitus pitch and edge of hearing loss in individuals with a narrow tinnitus bandwidth (2014)
Journal Article

Objective: Psychoacoustic measures of tinnitus, in particular dominant tinnitus pitch and its relationship to the shape of the audiogram, are important in determining and verifying pathophysiological mechanisms of the condition. Our previous study po... Read More about Relationship between tinnitus pitch and edge of hearing loss in individuals with a narrow tinnitus bandwidth.

Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD--'Assessing QbTest Utility in ADHD'(AQUA): a randomised controlled trial (2014)
Journal Article

Introduction: The National Institute for Health and Care Excellence (NICE) guidelines for attention deficit/hyperactivity disorder (ADHD) state that young people need to have access to the best evidence-based care to improve outcome. The current ‘gol... Read More about Protocol investigating the clinical utility of an objective measure of activity and attention (QbTest) on diagnostic and treatment decision-making in children and young people with ADHD--'Assessing QbTest Utility in ADHD'(AQUA): a randomised controlled trial.

What is 'Early intervention' for work related difficulties for people with multiple sclerosis?: a case study report (2014)
Journal Article

Background: Employment matters and at diagnosis most people with multiple sclerosis are in full time work or education. 75% of people with multiple sclerosis report the condition has impacted on this employment or career opportunities. Early interven... Read More about What is 'Early intervention' for work related difficulties for people with multiple sclerosis?: a case study report.

Football and dementia: A qualitative investigation of a community based sports group for men with early onset dementia (2014)
Journal Article

This study investigates the impact of a weekly group providing sport and physical activities for men with early onset dementia established by Notts County Football in the Community (NCFC). There were three aims: investigate the effect of early onset... Read More about Football and dementia: A qualitative investigation of a community based sports group for men with early onset dementia.

SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis (2014)
Journal Article

Aim: Acute bronchiolitis is the commonest cause for hospitalisation in infancy. Supportive care remains the cornerstone of current management and no other therapy has been shown to influence the course of the disease. It has been suggested that addin... Read More about SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis.

Vocational rehabilitation following traumatic brain injury: what is the evidence for clinical practice? (2014)
Journal Article

Traumatic brain injury (TBI) typically affects young adults with potentially many years of working life ahead of them. For people who were in work prior to their injury, return to work (RTW) is a common goal. However, a systematic review of RTW rat... Read More about Vocational rehabilitation following traumatic brain injury: what is the evidence for clinical practice?.

Interventions for deliberately altering blood pressure in acute stroke (2014)
Journal Article

Background: It is unclear whether blood pressure should be altered actively during the acute phase of stroke. This is an update of a Cochrane review first published in 1997, and previously updated in 2001 and 2008. Objectives: To assess the clinical... Read More about Interventions for deliberately altering blood pressure in acute stroke.

A randomised controlled trial of laser scanning and casting for the construction of ankle–foot orthoses (2014)
Journal Article

Study Design: Randomised controlled trial with blinding of orthotists and patients to the construction technique used. Background: Three-dimensional laser scanning has been used for patient measurement for cranial helmets and spinal braces. Ankle foo... Read More about A randomised controlled trial of laser scanning and casting for the construction of ankle–foot orthoses.

Selective insulin resistance in hepatocyte senescence. (2014)
Journal Article

Evaluating the impact of the reconfiguration of gynaecology services at a University Hospital NHS trust in the United Kingdom (2014)
Journal Article

Background: The project aim was to investigate the impact of reconfiguring gynaecology services on the key performance indicators of a University Hospital NHS Trust in the UK. The reconfiguration involved the centralisation of elective gynaecology... Read More about Evaluating the impact of the reconfiguration of gynaecology services at a University Hospital NHS trust in the United Kingdom.

A systematic review investigating interventions that can help reduce consumption of sugar-sweetened beverages in children leading to changes in body fatness (2014)
Journal Article

Background Both the prevalence of childhood obesity and the consumption of sugar-sweetened beverages (SSBs) have increased globally. The present review describes interventions that reduce the consumption of SSBs in children and determines whether... Read More about A systematic review investigating interventions that can help reduce consumption of sugar-sweetened beverages in children leading to changes in body fatness.

The senescent hepatocyte gene signature in chronic liver disease. (2014)
Journal Article

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer (2014)
Journal Article

HOX genes are master regulators of organ morphogenesis and cell differentiation during embryonic development, and continue to be expressed throughout post-natal life. To test the hypothesis that HOX genes are dysregulated in head and neck squamous ce... Read More about POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer.

The moving minimum audible angle is smaller during self motion than during source motion (2014)
Journal Article

We are rarely perfectly still: our heads rotate in three axes and move in three dimensions, constantly varying the spectral and binaural cues at the ear drums. In spite of this motion, static sound sources in the world are typically perceived as stab... Read More about The moving minimum audible angle is smaller during self motion than during source motion.

The effect of hearing aid microphone mode on performance in an auditory orienting task (2014)
Journal Article

OBJECTIVES: Although directional microphones on a hearing aid provide a signal-to-noise ratio benefit in a noisy background, the amount of benefit is dependent on how close the signal of interest is to the front of the user. It is assumed that whe... Read More about The effect of hearing aid microphone mode on performance in an auditory orienting task.

Surgical intervention versus expectant management for endometrial polyps in subfertile women (2014)
Journal Article

BACKGROUND: Endometrial polyps, which are benign growths of the endometrium, may be a factor in female subfertility. Possible mechanisms include physical interference with gamete transport, alteration of the endometrial milieu and unresponsiveness t... Read More about Surgical intervention versus expectant management for endometrial polyps in subfertile women.

Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation (2014)
Journal Article

The low-grade inflammatory state present in obesity contributes to obesity-related metabolic dysregulation, including nonalcoholic steatohepatitis (NASH) and insulin resistance. Intercellular interactions between immune cells or between immune cells... Read More about Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation.