All Outputs (816)

Domains relating to the everyday impact of hearing loss, as reported by patients or their communication partner(s): protocol for a systematic review (2016)
Journal Article
Vas, V., Akeroyd, M. A., & Hall, D. A. (2016). Domains relating to the everyday impact of hearing loss, as reported by patients or their communication partner(s): protocol for a systematic review. BMJ Open, 6(9), 1-6. https://doi.org/10.1136/bmjopen-2016-011463

INTRODUCTION: Hearing loss is a highly prevalent condition that affects around 1 in 6 people in the UK alone. This number is predicted to rise by the year 2031 to a staggering 14.5 million people due to the ageing population of the UK. Currently, th... Read More about Domains relating to the everyday impact of hearing loss, as reported by patients or their communication partner(s): protocol for a systematic review.

GameUp: Exergames for mobility – a project to keep elderly active (2016)
Conference Proceeding
Brox, E., Konstantinidis, S. T., Evertsen, G., Fernandez-Luque, L., Remartinez, A., Oesch, P., & Civit, A. (2016). GameUp: Exergames for mobility – a project to keep elderly active. In E. Kyriacou, S. Christofides, & C. S. Pattichis (Eds.), XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016 (1225–1230). https://doi.org/10.1007/978-3-319-32703-7_235

© Springer International Publishing Switzerland 2016. A big challenge for Europe is the demographic shift towards an aging population. Resources in the health care sector are limited, so it is important that the seniors of tomorrow will be able to st... Read More about GameUp: Exergames for mobility – a project to keep elderly active.

Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPAR? (2016)
Journal Article
Karwad, M. A., Macpherson, T., Wang, B., Theophilidou, E., Sarmad, S., Barrett, D. A., …O'Sullivan, S. (2017). Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARα. FASEB Journal, 31(2), 469-481. https://doi.org/10.1096/fj.201500132

Cannabinoids modulate intestinal permeability through cannabinoid receptor 1 (CB1). The endocannabinoid-like compounds oleoylethanolamine (OEA) and palmitoylethanolamine (PEA) play an important role in digestive regulation, and we hypothesized they w... Read More about Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPAR?.

The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries (2016)
Journal Article
Stanley, C. P., Hind, W. H., Tufarelli, C., & O'Sullivan, S. (2016). The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries. Pharmacological Research, 113(A), 356-363. https://doi.org/10.1016/j.phrs.2016.08.028

The endocannabinoid anandamide (AEA) causes vasorelaxation in animal studies. Although circulating AEA levels are increased in many pathologies, little is known about its vascular effects in humans. The aim of this work was to characterise the effect... Read More about The endocannabinoid anandamide causes endothelium-dependent vasorelaxation in human mesenteric arteries.

The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain (2016)
Journal Article
Hulse, R. P., Drake, R. A., Bates, D. O., & Donaldson, L. F. (in press). The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain. Neurobiology of Disease, 96, https://doi.org/10.1016/j.nbd.2016.09.009

Neuropathic pain results from neuroplasticity in nociceptive neuronal networks. Here we demonstrate that control of alternative pre-mRNA splicing, through the splice factor serine-arginine splice factor 1 (SRSF1), is integral to the processing of noc... Read More about The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain.

The ethical issues regarding consent to clinical trials with pre-term or sick neonates: a systematic review (framework synthesis) of the analytical (theoretical/philosophical) research (2016)
Journal Article
Megone, C., Wilman, E., Oliver, S., Duley, L., Gyte, G., & Wright, J. (2016). The ethical issues regarding consent to clinical trials with pre-term or sick neonates: a systematic review (framework synthesis) of the analytical (theoretical/philosophical) research. Trials, 17(1), https://doi.org/10.1186/s13063-016-1562-3

Background: Conducting clinical trials with pre-term or sick infants is important if care for this population is to be underpinned by sound evidence. Yet, approaching the parents of these infants at such a difficult time raises challenges to obtainin... Read More about The ethical issues regarding consent to clinical trials with pre-term or sick neonates: a systematic review (framework synthesis) of the analytical (theoretical/philosophical) research.

Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study (2016)
Journal Article
Mackenzie, I. S., Ford, I., Walker, A., Hawkey, C., Begg, A., Avery, A., …MacDonald, T. M. (2016). Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study. BMJ Open, 6(9), Article e013774. https://doi.org/10.1136/bmjopen-2016-013774

Introduction Ischaemic heart disease (IHD) is one of the most common causes of death in the UK and treatment of patients with IHD costs the National Health System (NHS) billions of pounds each year. Allopurinol is a xanthine oxidase inhibitor use... Read More about Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study.

Low-dose salinomycin induces anti-leukemic responses in AML and MLL (2016)
Journal Article
Roulston, G. D., Burt, C. L., Kettyle, L. M., Matchett, K. B., Keenan, H. L., Mulgrew, N. M., …Thompson, A. (2016). Low-dose salinomycin induces anti-leukemic responses in AML and MLL. Oncotarget, https://doi.org/10.18632/oncotarget.11866

Development of anti-cancer drugs towards clinical application is costly and inefficient. Large screens of drugs, efficacious for non-cancer disease, are currently being used to identify candidates for repurposing based on their anti-cancer properties... Read More about Low-dose salinomycin induces anti-leukemic responses in AML and MLL.

Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers (2016)
Journal Article
Ahmad, D. A. J., Negm, O. H., Layth Alabdullah, M., Mirza, S., Hamed, M. R., Band, V., …Rakha, E. (2016). Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers. Breast Cancer Research and Treatment, 159(3), 457-467. https://doi.org/10.1007/s10549-016-3967-9

Background Mitogen-activated protein kinases (MAPKs) are signalling transduction molecules that have different functions and diverse behaviour in cancer. In breast cancer, MAPK is related to oestrogen receptor (ER) and HER2. Methods Protein express... Read More about Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers.

Relative efficacy of different types of exercise for treatment of knee and hip osteoarthritis: Protocol for network meta-analysis of randomised controlled trials (2016)
Journal Article
Goh, S., Persson, M., Bhattacharya, A., Hall, M. C., Doherty, M., & Zhang, W. (2016). Relative efficacy of different types of exercise for treatment of knee and hip osteoarthritis: Protocol for network meta-analysis of randomised controlled trials. Systematic Reviews, 5(147), https://doi.org/10.1186/s13643-016-0321-6

Background: “Exercise” is universally recommended as a core treatment for knee and hip osteoarthritis (OA). However, there are very few head-to-head comparative trials to determine the relative efficacy between different types of exercise. The aim of... Read More about Relative efficacy of different types of exercise for treatment of knee and hip osteoarthritis: Protocol for network meta-analysis of randomised controlled trials.

Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches (2016)
Journal Article
Onyido, E. K., Sweeney, E., & Nateri, A. S. (2016). Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches. Molecular Cancer, 15(56), https://doi.org/10.1186/s12943-016-0541-3

Over the past few years, microRNAs (miRNAs) have not only emerged as integral regulators of gene expression at the post-transcriptional level but also respond to signalling molecules to affect cell function(s). miRNAs crosstalk with a variety of the... Read More about Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches.

Qualitative exploration of the benefits of group-based memory rehabilitation for people with neurological disabilities: implications for rehabilitation delivery and evaluation (2016)
Journal Article
Chouliara, N., & Lincoln, N. (2016). Qualitative exploration of the benefits of group-based memory rehabilitation for people with neurological disabilities: implications for rehabilitation delivery and evaluation. BMJ Open, 6(9), 1-11. https://doi.org/10.1136/bmjopen-2016-011225

Objective: To identify patient-perceived benefits of memory rehabilitation and draw transferrable lessons for the delivery and evaluation of similar interventions for people with neurological disabilities. Methods: A qualitative study was conducte... Read More about Qualitative exploration of the benefits of group-based memory rehabilitation for people with neurological disabilities: implications for rehabilitation delivery and evaluation.

Heritability of non-speech auditory processing skills (2016)
Journal Article
Brewer, C. C., Zalewski, C. K., King, K. A., Zobay, O., Riley, A., Ferguson, M. A., …Moore, D. R. (2016). Heritability of non-speech auditory processing skills. European Journal of Human Genetics, 24(8), https://doi.org/10.1038/ejhg.2015.277

Recent insight into the genetic bases for autism spectrum disorder, dyslexia, stuttering, and language disorders suggest that neurogenetic approaches may also reveal at least one etiology of auditory processing disorder (APD). A person with an APD ty... Read More about Heritability of non-speech auditory processing skills.

The Human Connectome Project's neuroimaging approach (2016)
Journal Article
Glasser, M. F., Smith, S. M., Marcus, D. S., Andersson, J. L., Auerbach, E. J., Behrens, T. E., …Van Essen, D. C. (2016). The Human Connectome Project's neuroimaging approach. Nature Neuroscience, 19(9), https://doi.org/10.1038/nn.4361

Noninvasive human neuroimaging has yielded many discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis and s... Read More about The Human Connectome Project's neuroimaging approach.

Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults (2016)
Journal Article
Kitterick, P. T., Smith, S. N., & Lucas, L. (2016). Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults. Ear and Hearing, 37(5), https://doi.org/10.1097/AUD.0000000000000313

Objectives: A systematic review of the literature and meta-analysis was conducted to assess the nature and quality of the evidence for the use of hearing instruments in adults with a unilateral severe-to-profound sensorineural hearing loss. Design:... Read More about Hearing instruments for unilateral severe-to-profound sensorineural hearing loss in adults.

Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation (2016)
Journal Article
Aldajani, W. A., Salazar, F., Sewell, H. F., Knox, A., & Ghaemmaghami, A. M. (2016). Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation. Oncotarget, 7(36), https://doi.org/10.18632/oncotarget.11586

Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally referred to as kynurenines. It has become inc... Read More about Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation.

What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials (2016)
Journal Article
Nankervis, H., Thomas, K., Delamere, F. M., Barbarot, S., Smith, S., Rogers, N. K., & Williams, H. C. (in press). What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials. British Journal of Dermatology, 176(4), https://doi.org/10.1111/bjd.14999

Atopic eczema (AE) is a common chronic inflammatory skin condition. Whilst many AE treatment options are available, the evidence to support their efficacy varies in depth and quality. In 2000, an NIHR HTA systematic review identified and evaluated ex... Read More about What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials.

Effect of contralateral medial olivocochlear feedback on perceptual estimates of cochlear gain and compression (2016)
Journal Article
Fletcher, M. D., Krumbholz, K., & de Boer, J. (2016). Effect of contralateral medial olivocochlear feedback on perceptual estimates of cochlear gain and compression. Journal of the Association for Research in Otolaryngology, 17(6), 559-575. https://doi.org/10.1007/s10162-016-0574-8

The active cochlear mechanism amplifies responses to low-intensity sounds, compresses the range of input sound intensities to a smaller output range, and increases cochlear frequency selectivity. The gain of the active mechanism can be modulated by t... Read More about Effect of contralateral medial olivocochlear feedback on perceptual estimates of cochlear gain and compression.

Running and knee osteoarthritis: a systematic review and meta-analysis (2016)
Journal Article
Timmins, K. A., Batt, M. E., & Edwards, K. L. (2017). Running and knee osteoarthritis: a systematic review and meta-analysis. American Journal of Sports Medicine, 45(6), https://doi.org/10.1177/0363546516657531

Background: Osteoarthritis (OA) is a chronic condition characterized by pain, impaired function, and reduced quality of life. A number of risk factors for knee OA have been identified, such as obesity, occupation, and injury. The association between... Read More about Running and knee osteoarthritis: a systematic review and meta-analysis.

Gene pathway development in human epicardial adipose tissue during early life (2016)
Journal Article
Ojha, S., Fainberg, H. P., Wilson, V., Pelella, G., Castellanos, M., May, S., …Budge, H. (in press). Gene pathway development in human epicardial adipose tissue during early life. JCI insight, 1(13), Article e87460. https://doi.org/10.1172/jci.insight.87460

Studies in rodents and newborn humans demonstrate the influence of brown adipose tissue (BAT) in temperature control and energy balance and a critical role in the regulation of body weight. Here, we obtained samples of epicardial adipose tissue (EAT)... Read More about Gene pathway development in human epicardial adipose tissue during early life.