All Outputs (145)

The efficacy of unsupervised home-based exercise regimens in comparison to supervised lab-based exercise training upon cardio-respiratory health facets (2017)
Journal Article
Blackwell, J., Atherton, P. J., Smith, K., Doleman, B., Williams, J. P., Lund, J. N., & Phillips, B. E. (2017). The efficacy of unsupervised home-based exercise regimens in comparison to supervised lab-based exercise training upon cardio-respiratory health facets. Physiological Reports, 5(16), Article e13390. https://doi.org/10.14814/phy2.13390

Supervised high-intensity interval training (HIIT) can rapidly improve cardiorespiratory fitness (CRF). However, the effectiveness of time-efficient unsupervised home-based interventions is unknown. Eighteen volunteers completed either: laboratory-HI... Read More about The efficacy of unsupervised home-based exercise regimens in comparison to supervised lab-based exercise training upon cardio-respiratory health facets.

Alcohol consumption and risk of common cancers: evidence from a cohort of adults from the United Kingdom (2017)
Journal Article
Betts, G., Ratschen, E., Opazo-Breton, M., & Grainge, M. J. (2018). Alcohol consumption and risk of common cancers: evidence from a cohort of adults from the United Kingdom. Journal of Public Health, 40(3), 540–548. https://doi.org/10.1093/pubmed/fdx123

Background: Recent guidelines from the United Kingdom recommend that men and women should drink no more than 14 units of alcohol per week. This recommendation takes into account the link between alcohol and several cancers; however, there is a dearth... Read More about Alcohol consumption and risk of common cancers: evidence from a cohort of adults from the United Kingdom.

Experience of self-harm and its treatment in looked-after young people: an interpretative phenomenological analysis (2017)
Journal Article
Wadman, R., Armstrong, M., Clarke, D., Harroe, C., Majumder, P., Sayal, K., …Townsend, E. (in press). Experience of self-harm and its treatment in looked-after young people: an interpretative phenomenological analysis. Archives of Suicide Research, 22(3), https://doi.org/10.1080/13811118.2017.1355286

Objectives: We report the first Interpretative Phenomenological Analysis examination of self-harm and experience of clinical services in young people in the public care system. Methods: Qualitative interviews with 24 looked-after young people. Result... Read More about Experience of self-harm and its treatment in looked-after young people: an interpretative phenomenological analysis.

Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans (2017)
Journal Article
Valdes, A. M., Ravipati, S., Menni, C., Abhishek, A., Metrustry, S., Harris, J., …Barrett, D. A. (in press). Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Scientific Reports, 7, Article 10748. https://doi.org/10.1038/s41598-017-09516-3

Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models... Read More about Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.

Assessing the impact of the introduction of an electronic hospital discharge system on the completeness and timeliness of discharge communication: a before and after study (2017)
Journal Article
Mehta, R., Baxendale, B., Roth, K., Caswell, V., Le Jeune, I., Hawkins, J., …Avery, A. J. (2017). Assessing the impact of the introduction of an electronic hospital discharge system on the completeness and timeliness of discharge communication: a before and after study. BMC Health Services Research, 17, Article 624. https://doi.org/10.1186/s12913-017-2579-3

Background: Hospital discharge summaries are a key communication tool ensuring continuity of care between primary and secondary care. Incomplete or untimely communication of information increases risk of hospital readmission and associated compl... Read More about Assessing the impact of the introduction of an electronic hospital discharge system on the completeness and timeliness of discharge communication: a before and after study.

Development of a method for determining binaural sensitivity to temporal fine structure (2017)
Journal Article
Füllgrabe, C., Harland, A. J., Sęk, A. P., & Moore, B. C. (2017). Development of a method for determining binaural sensitivity to temporal fine structure. International Journal of Audiology, https://doi.org/10.1080/14992027.2017.1366078

Objective: To develop and evaluate a test of the ability to process binaural temporal-fine-structure (TFS) information. The test was intended to provide a graded measure of TFS sensitivity for all listeners. Design: Sensitivity to TFS was assessed at... Read More about Development of a method for determining binaural sensitivity to temporal fine structure.

A Neural Basis for Contagious Yawning (2017)
Journal Article
Brown, B. J., Kim, S., Saunders, H., Bachmann, C., Thompson, J., Ropar, D., …Jackson, G. M. (2017). A Neural Basis for Contagious Yawning. Current Biology, 27(17), 2713-2717.e2. https://doi.org/10.1016/j.cub.2017.07.062

Contagious yawning, in which yawning is triggered involuntarily when we observe another person yawn, is a common form of echophenomena—the automatic imitation of another’s words (echolalia) or actions (echopraxia) [1]. The neural basis for echophenom... Read More about A Neural Basis for Contagious Yawning.

The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHES randomised controlled trial (2017)
Journal Article
Wake, E., Batchelor, J. M., Lawton, S., Thomas, K., Harrison, E. F., & Cowdell, F. (2018). The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHES randomised controlled trial. British Journal of Dermatology, 178(1), 183-190. https://doi.org/10.1111/bjd.15909

Background: Many children suffer with skin diseases, but to date, most dermatological research has been done ‘on’ rather than ‘with’ children; in this study we actively sought the experiences of children and young people. Atopic eczema (AE) is a chro... Read More about The views of children and young people on the use of silk garments for the treatment of eczema: a nested qualitative study within the CLOTHES randomised controlled trial.

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand (2017)
Journal Article
Hollander, W. D., Boer, C. G., Hart, D. J., Yau, M. S., Ramos, Y. F., Metrustry, S., …van Meurs, J. J. (2017). Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2017-211214

Objective Osteoarthritis (OA) is the most common form of arthritis and the leading cause of disability in the elderly. Of all the joints, genetic predisposition is strongest for OA of the hand; however, only few genetic risk loci for hand OA have bee... Read More about Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.

Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice (2017)
Journal Article
Lewis, J. E., Samms, R. J., Cooper, S., Luckett, J. C., Perkins, A. C., Dunbar, J. D., …Tsintzas, K. (2017). Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice. Endocrinology, 158(10), 3090–3096. https://doi.org/10.1210/en.2017-00591

The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growt... Read More about Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice.

Systematic review of interventions for treating or preventing antipsychotic-induced tardive dyskinesia (2017)
Journal Article
Bergman, H., Walker, D., Nikolakopoulou, A., Soares-Weiser, K., & Adams, C. E. (in press). Systematic review of interventions for treating or preventing antipsychotic-induced tardive dyskinesia. Health Technology Assessment, 21(43), https://doi.org/10.3310/hta21430

Background: Antipsychotic medication can cause tardive dyskinesia (TD) – late-onset, involuntary, repetitive movements, often involving the face and tongue. TD occurs in > 20% of adults taking antipsychotic medication (first-generation antipsychotics... Read More about Systematic review of interventions for treating or preventing antipsychotic-induced tardive dyskinesia.

Automatic speech recognition predicts speech intelligibility and comprehension for listeners with simulated age-related hearing loss (2017)
Journal Article
Fontan, L., Ferrané, I., Farinas, J., Pinquier, J., Tardieu, J., Magnen, C., …Füllgrabe, C. (in press). Automatic speech recognition predicts speech intelligibility and comprehension for listeners with simulated age-related hearing loss. Journal of Speech, Language, and Hearing Research, https://doi.org/10.1044/2017_JSLHR-S-16-0269

Purpose: To assess speech processing for listeners with simulated age-related hearing loss (ARHL) and to investigate whether the observed performance can be replicated using an Automatic Speech Recognition (ASR) system. The long-term goal of this re... Read More about Automatic speech recognition predicts speech intelligibility and comprehension for listeners with simulated age-related hearing loss.

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia (2017)
Journal Article
Ware, J. S., Wain, L. V., Channavajjhala, S. K., Jackson, V. E., Edwards, E., Lu, R., …Glover, M. (2017). Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia. Journal of Clinical Investigation, 127(9), 3367-3374. https://doi.org/10.1172/JCI89812

Thiazide diuretics are among the most widely used treatments for hypertension, but thiazide-induced hyponatremia (TIH), a clinically significant adverse effect, is poorly understood. Here, we have studied the phenotypic and genetic characteristics of... Read More about Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia.

Introducing the Care Certificate evaluation (innovative practice) (2017)
Journal Article
Argyle, E., Thomson, L., Arthur, A., Maben, J., Schneider, J. M., & Wharrad, H. (in press). Introducing the Care Certificate evaluation (innovative practice). Dementia, https://doi.org/10.1177/1471301217723498

Although investment in staff development is a prerequisite for high quality and innovative care, the training needs of unregistered care staff have often been neglected, particularly within dementia care provision. The Care Certificate, which was ful... Read More about Introducing the Care Certificate evaluation (innovative practice).

Unregistered health care staff's perceptions of 12 hour shifts: an interview study (2017)
Journal Article
Thomson, L., Schneider, J. M., & Hare Duke, L. (in press). Unregistered health care staff's perceptions of 12 hour shifts: an interview study. Journal of Nursing Management, 25(7), https://doi.org/10.1111/jonm.12490

Aim The purpose of the study was to explore the unregistered health care staff’s perceptions of 12-hour shifts on work performance and patient care. Background Many unregistered health care staff work 12-hour shifts. It is unclear whether... Read More about Unregistered health care staff's perceptions of 12 hour shifts: an interview study.

Acute effect of pore-forming Clostridium perfringens ?-toxin on compound action potentials of optic nerve of mouse (2017)
Journal Article
Cases, M., Brown, A., Llobet, A., Terni, B., Gómez de Aranda, I., Blanch, M., …Solsona, C. (2017). Acute effect of pore-forming Clostridium perfringens ε-toxin on compound action potentials of optic nerve of mouse. eNeuro, 4(4)(e0051-17), Article e0051-17. https://doi.org/10.1523/ENEURO.0051-17.2017

ε-Toxin is a pore forming toxin produced by Clostridium perfringens types B and D. It is synthesized as a less active prototoxin form that becomes fully active upon proteolytic activation. The toxin produces highly lethal enterotoxaemia in ruminants,... Read More about Acute effect of pore-forming Clostridium perfringens ?-toxin on compound action potentials of optic nerve of mouse.

Fifteen minute consultation: stabilisaton of the high risk newborn infant beside the mother (2017)
Journal Article
Batey, N., Yoxall, B., Fawke, J., Duley, L., & Dorling, J. (2017). Fifteen minute consultation: stabilisaton of the high risk newborn infant beside the mother. Archives of Disease in Childhood, 102, https://doi.org/10.1136/archdischild-2016-312276

Paediatric and adult resuscitation is often performed with family present. Current guidelines recommend deferred umbilical cord clamping as part of immediate neonatal care, requiring neonatal assessment next to the mother. This paper describes strate... Read More about Fifteen minute consultation: stabilisaton of the high risk newborn infant beside the mother.

Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial (2017)
Journal Article
Chalmers, J. R., Haines, R. H., Mitchell, E. J., Thomas, K. S., Brown, S. J., Ridd, M., …Williams, H. C. (2017). Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial. Trials, 18(1), Article 343. https://doi.org/10.1186/s13063-017-2031-3

Background: Atopic eczema (AE) is a common skin problem that impairs quality of life and is associated with the development of other atopic diseases including asthma, food allergy and allergic rhinitis. AE treatment is a significant cost burden for... Read More about Effectiveness and cost effectiveness of daily all over body application of emollient during the first year of life for preventing atopic eczema in high risk children (The BEEP trial): protocol for a randomised controlled trial.

Influence of microphone housing on the directional response of piezoelectric MEMS microphones inspired by Ormia ochracea (2017)
Journal Article
Bauer, R., Zhang, Y., Jackson, J. C., Whitmer, W. M., Brimijoin, W. O., Akeroyd, M. A., …Windmill, J. F. (2017). Influence of microphone housing on the directional response of piezoelectric MEMS microphones inspired by Ormia ochracea. IEEE Sensors Journal, 17(17), 5529 - 5536. https://doi.org/10.1109/JSEN.2017.2729619

The influence of custom microphone housings on the acoustic directionality and frequency response of a multi-band bio-inspired MEMS microphone is presented. The 3.2mm by 1.7mm piezoelectric MEMS microphone, fabricated by a cost-effective multi-user p... Read More about Influence of microphone housing on the directional response of piezoelectric MEMS microphones inspired by Ormia ochracea.

Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Almutairi, F. M., Aggour, A. M., & Carter, W. (2017). Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations. Toxicology in Vitro, 44, https://doi.org/10.1016/j.tiv.2017.07.011

Antidepressants are commonly employed for the treatment of major depressive disorders and other psychiatric conditions. We investigated the relatively acute cytotoxic effects of three commonly prescribed antidepressants: fluoxetine, sertraline, and c... Read More about Antidepressants are cytotoxic to rat primary blood brain barrier endothelial cells at high therapeutic concentrations.