All Outputs (1390)

Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection (2021)
Journal Article

The canine epigastric organs, their locations and visualization of these components are essential for veterinary practice and anatomical research. Despite their importance, conflicts and discrepancies in the published material, to date, still exist,... Read More about Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection.

Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review (2021)
Working Paper

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important... Read More about Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review.

Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses (2021)
Journal Article

Hydroxyzine and cetirizine are first- and second-generation oral antihistamine drugs, respectively, used to treat allergic reactions in horses. Cetirizine is also a metabolite of hydroxyzine, which may lead to complexities in regulating their use in... Read More about Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses.

Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties (2021)
Journal Article

Low-power sonication is widely used to disaggregate extracellular vesicles (EVs) after isolation, however, the effects of sonication on EV samples beyond dispersion are unclear. The present study analysed the characteristics of EVs collected from mes... Read More about Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties.

Results of urinary bacterial cultures and antibiotic susceptibility testing of dogs and cats in the UK (2021)
Journal Article

Objectives Bacterial urinary tract infections are a common diagnosis in small animal practice and antibiotics are often administered empirically. The aim of this study was to investigate the aetiology and antibiotic resistance of uropathogens in dog... Read More about Results of urinary bacterial cultures and antibiotic susceptibility testing of dogs and cats in the UK.

Opening forces or failure of commercially available equine headcollars and other safety devices (2021)
Journal Article

A recent survey by the authors of the present study indicated that headcollar (halter, USA) related incidents resulting in horse injuries may be common. From the survey, 134 incidents involving horse fractures and 167 fatalities were reported. Headco... Read More about Opening forces or failure of commercially available equine headcollars and other safety devices.

Assessment of health and welfare in a small sample of dogs owned by people who are homeless (2021)
Journal Article

Background: Pet ownership is common among homeless people, with dogs the most frequently reported pets. However, homeless people receive considerable criticism for keeping pets due to public perception of poor care provision. Materials and methods: A... Read More about Assessment of health and welfare in a small sample of dogs owned by people who are homeless.

“Refugees from practice”? Exploring why some vets move from the clinic to the laboratory (2021)
Journal Article

Background: Named veterinary surgeons (NVSs) are a mandated presence in licensed animal research establishments in the UK. Some NVSs come into their laboratory roles having left general veterinary practice, which is currently facing significant recru... Read More about “Refugees from practice”? Exploring why some vets move from the clinic to the laboratory.

Antimicrobial resistance profiles of bacteria associated with lower respiratory tract infections in cats and dogs in England (2021)
Journal Article

Background: Bacterial lower respiratory tract infections (bLRTIs) are common and potentially life threatening in cats and dogs. Antibiotic treatment is often initiated before the diagnosis of bLRTI; therefore improved knowledge of the aetiology and a... Read More about Antimicrobial resistance profiles of bacteria associated with lower respiratory tract infections in cats and dogs in England.

Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma (2021)
Journal Article

Osteosarcoma (OSA) is an aggressive bone malignancy. Unlike many other malignancies, OSA outcomes have not improved in recent decades. One challenge to the development of better diagnostic and therapeutic methods for OSA has been the lack of well cha... Read More about Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma.

Priorities for Research into the Impact of Canine Surgical Sterilisation Programmes for Free-Roaming Dogs: An International Priority Setting Partnership (2021)
Journal Article

Surgical sterilisation is a core activity of free-roaming dog population management (DPM) programmes globally. However, there is limited published evidence on its impact at the population level. To support evidence-based decision making in this field... Read More about Priorities for Research into the Impact of Canine Surgical Sterilisation Programmes for Free-Roaming Dogs: An International Priority Setting Partnership.

Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes (2021)
Journal Article

Bluetongue (BT) is a severe and economically important disease of ruminants that is widely distributed around the world, caused by the bluetongue virus (BTV). More than 28 different BTV serotypes have been identified in serum neutralisation tests (SN... Read More about Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes.

Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers (2021)
Journal Article

Rationale: The human ligases (LIG1, LIG3 and LIG4) are essential for the maintenance of genomic integrity by catalysing the formation of phosphodiester bonds between adjacent 5'-phosphoryl and 3'-hydroxyl termini at single and double strand breaks in... Read More about Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers.

Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved (2021)
Journal Article

Statin derivatives can inhibit the replication of a range of viruses, including hepatitis C virus (HCV, Hepacivirus), dengue virus (Flavivirus), African swine fever virus (Asfarviridae) and poliovirus (Picornaviridae). We assess the antiviral effect... Read More about Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved.

Is thoracic ultrasound more efficient than the Wisconsin calf scoring system for the detection of pneumonia in calves? (2021)
Journal Article

Detecting Dairy Cow Behavior Using Vision Technology (2021)
Journal Article

The aim of this study was to investigate using existing image recognition techniques to predict the behavior of dairy cows. A total of 46 individual dairy cows were monitored continuously under 24 h video surveillance prior to calving. The video was... Read More about Detecting Dairy Cow Behavior Using Vision Technology.

A Scoping Review of West Nile Virus Seroprevalence Studies among African Equids (2021)
Journal Article

West Nile virus (WNV) is an emerging and re-emerging zoonotic flavivirus first identified in and endemic to Africa. The virus is transmitted between birds by biting mosquitoes, with equids and humans being incidental hosts. The majority of infected i... Read More about A Scoping Review of West Nile Virus Seroprevalence Studies among African Equids.

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India (2021)
Journal Article

Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consu... Read More about Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India.

Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies (2021)
Journal Article

Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can resu... Read More about Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies.

Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution (2021)
Journal Article

Ethylene is a small hydrocarbon gas widely used in the chemical industry. Annual worldwide production currently exceeds 150 million tons, producing considerable amounts of CO2 contributing to climate change. The need for a sustainable alternative is... Read More about Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution.