All Outputs (8)

Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China (2024)
Journal Article
Baker, M., Zhang, X., Maciel-Guerra, A., Babaarslan, K., Dong, Y., Wang, W., …Dottorini, T. (2024). Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China. Nature Communications, 15, Article 206. https://doi.org/10.1038/s41467-023-44272-1

Sharing of genetic elements among different pathogens and commensals inhabiting same hosts and environments has significant implications for antimicrobial resistance (AMR), especially in settings with high antimicrobial exposure. We analysed 661 Esch... Read More about Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China.

A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment (2023)
Journal Article
Todman, H., Arya, S., Baker, M., & Stekel, D. J. (2023). A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment. PLoS ONE, 18(8), Article e0289941. https://doi.org/10.1371/journal.pone.0289941

Antimicrobial resistant bacterial infections represent one of the most serious contemporary global healthcare crises. Acquisition and spread of resistant infections can occur through community, hospitals, food, water or endogenous bacteria. Global ef... Read More about A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment.

Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock (2022)
Journal Article
Maciel-Guerra, A., Baker, M., Hu, Y., Wang, W., Zhang, X., Rong, J., …Dottorini, T. (2023). Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock. ISME Journal, 17, 21-35. https://doi.org/10.1038/s41396-022-01315-7

A debate is currently ongoing as to whether intensive livestock farms may constitute reservoirs of clinically relevant antimicrobial resistance (AMR), thus posing a threat to surrounding communities. Here, combining shotgun metagenome sequencing, mac... Read More about Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock.

Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control (2022)
Journal Article
Baker, M., Williams, A. D., Hooton, S. P., Helliwell, R., King, E., Dodsworth, T., …Stekel, D. J. (2022). Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control. Environment International, 169, Article 107516. https://doi.org/10.1016/j.envint.2022.107516

Waste from dairy production is one of the largest sources of contamination from antimicrobial resistant bacteria (ARB) and genes (ARGs) in many parts of the world. However, studies to date do not provide necessary evidence to inform antimicrobial res... Read More about Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control.

Whole-genome sequencing and gene sharing network analysis powered by machine learning identifies antibiotic resistance sharing between animals, humans and environment in livestock farming (2022)
Journal Article
Peng, Z., Maciel-Guerra, A., Baker, M., Zhang, X., Hu, Y., Wang, W., …Dottorini, T. (2022). Whole-genome sequencing and gene sharing network analysis powered by machine learning identifies antibiotic resistance sharing between animals, humans and environment in livestock farming. PLoS Computational Biology, 18(3), Article e1010018. https://doi.org/10.1371/journal.pcbi.1010018

Anthropogenic environments such as those created by intensive farming of livestock, have been proposed to provide ideal selection pressure for the emergence of antimicrobial-resistant Escherichia coli bacteria and antimicrobial resistance genes (ARGs... Read More about Whole-genome sequencing and gene sharing network analysis powered by machine learning identifies antibiotic resistance sharing between animals, humans and environment in livestock farming.

Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China (2022)
Journal Article
Wang, W., Hu, Y., Baker, M., Dottorini, T., Li, H., Dong, Y., …Li, F. (2022). Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China. Journal of Antimicrobial Chemotherapy, 77(4), 903-909. https://doi.org/10.1093/jac/dkab500

Background Staphylococcal cassette chromosome mec (SCCmec) elements are highly diverse and have been classified into 14 types. Novel SCCmec variants have been frequently detected from humans and animals but rarely from food. Objectives To charac... Read More about Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China.

Genome-Scale Metabolic Models and Machine Learning Reveal Genetic Determinants of Antibiotic Resistance in Escherichia coli and Unravel the Underlying Metabolic Adaptation Mechanisms (2021)
Journal Article
Pearcy, N., Hu, Y., Baker, M., Maciel-Guerra, A., Xue, N., Wang, W., …Dottorini, T. (2021). Genome-Scale Metabolic Models and Machine Learning Reveal Genetic Determinants of Antibiotic Resistance in Escherichia coli and Unravel the Underlying Metabolic Adaptation Mechanisms. mSystems, 6(4), Article e00913-20. https://doi.org/10.1128/mSystems.00913-20

Antimicrobial resistance (AMR) is becoming one of the largest threats to public health worldwide, with the opportunistic pathogen Escherichia coli playing a major role in the AMR global health crisis. Unravelling the complex interplay between drug re... Read More about Genome-Scale Metabolic Models and Machine Learning Reveal Genetic Determinants of Antibiotic Resistance in Escherichia coli and Unravel the Underlying Metabolic Adaptation Mechanisms.

Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster (2021)
Journal Article
Peng, Z., Dottorini, T., Hu, Y., Li, M., Yan, S., Fanning, S., …Li, F. (2021). Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster. Frontiers in Microbiology, 12, Article 628538. https://doi.org/10.3389/fmicb.2021.628538

The environmental bacterium Burkholderia gladioli pv. cocovenenans (B. cocovenenans) has been linked to fatal food poisoning cases in Asia and Africa. Bongkrekic acid (BA), a mitochondrial toxin produced by B. cocovenenans, is thought to be responsib... Read More about Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster.