Skip to main content

Research Repository

Advanced Search

All Outputs (1388)

Effect of delivery method on the efficacy of Salmonella vaccination in chickens (2010)
Journal Article
Atterbury, R. J., Morris, V., Harrison, D., Tucker, V., Allen, V., Davies, R., & Carrique-Mas, J. (2010). Effect of delivery method on the efficacy of Salmonella vaccination in chickens. Veterinary Record, 167(5), https://doi.org/10.1136/vr.b4884

To investigate whether the efficacy of live vaccines is influenced by the mode of vaccine delivery, a widely-used UK live commercial Salmonella Enteritidis vaccine was delivered to pullet chicks either by spray, in drinking water, or in combination w... Read More about Effect of delivery method on the efficacy of Salmonella vaccination in chickens.

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing (2010)
Journal Article
James, V., Zhang, Y., Foxler, D. E., de Moor, C. H., Kong, Y. W., Webb, T. M., …Sharp, T. V. (2010). LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proceedings of the National Academy of Sciences, 107(28), 12499-12504. https://doi.org/10.1073/pnas.0914987107

In recent years there have been major advances with respect to the identification of the protein components and mechanisms of microRNA (miRNA) mediated silencing. However, the complete and precise repertoire of components and mechanism(s) of action r... Read More about LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability (2010)
Journal Article
Carter, S. D., Dent, K. C., Atkins, E., Foster, T. L., Verow, M., Gorny, P., …Barr, J. N. (2010). Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability. FEBS Letters, 584(13), 2786-2790. https://doi.org/10.1016/j.febslet.2010.05.006

Human respiratory syncytial virus (HRSV) is the leading cause of lower respiratory tract disease in infants. The HRSV small hydrophobic (SH) protein plays an important role in HRSV pathogenesis, although its mode of action is unclear. Analysis of the... Read More about Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability.

Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif (2009)
Journal Article
Egan, S. A., Kurian, D., Ward, P. N., Hunt, L., & Leigh, J. A. (2009). Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif. Journal of Proteome Research, 9(2), https://doi.org/10.1021/pr901025w

Sortase (a transamidase) has been shown to be responsible for the covalent attachment of proteins to the bacterial cell wall. Anchoring is effected on secreted proteins containing a specific cell wall motif toward their C-terminus; that for sortase A... Read More about Identification of sortase A (SrtA) substrates in Streptococcus uberis: evidence for an additional hexapeptide (LPXXXD) sorting motif.

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis (2009)
Journal Article
Rutland, C., Warner, L., Thorpe, A., Alibhai, A., Robinson, T., Shaw, B., …Loughna, S. (2009). Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis. Journal of Anatomy, 214(6), 905-915. https://doi.org/10.1111/j.1469-7580.2009.01079.x

Atrial septal defects are a common congenital heart defect in humans. Although mutations in different genes are now frequently being described, little is known about the processes and mechanisms behind the early stages of atrial septal development. B... Read More about Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis.

Management interventions in dairy herds: exploring within herd uncertainty using an integrated Bayesian model (2009)
Journal Article
Green, M. J., Medley, G. F., Bradley, A. J., & Browne, W. J. (2009). Management interventions in dairy herds: exploring within herd uncertainty using an integrated Bayesian model. Veterinary Research, 41(2), Article Article 22. https://doi.org/10.1051/vetres/2009070

Knowledge of the efficacy of an intervention for disease control on an individual farm is essential to make good decisions on preventive healthcare, but the uncertainty in outcome associated with undertaking a specific control strategy has rarely b... Read More about Management interventions in dairy herds: exploring within herd uncertainty using an integrated Bayesian model.

Bayesian analysis of a mastitis control plan to investigate the influence of veterinary prior beliefs on clinical interpretation (2009)
Journal Article
Green, M. J., Browne, W. J., Green, L., Bradley, A. J., Leach, K., Breen, J., & Medley, G. F. (2009). Bayesian analysis of a mastitis control plan to investigate the influence of veterinary prior beliefs on clinical interpretation. Preventive Veterinary Medicine, 91(2-4), https://doi.org/10.1016/j.prevetmed.2009.05.029

The fundamental objective for health research is to determine whether changes should be made to clinical decisions. Decisions made by veterinary surgeons in the light of new research evidence are known to be influenced by their prior beliefs, especia... Read More about Bayesian analysis of a mastitis control plan to investigate the influence of veterinary prior beliefs on clinical interpretation.

Use of posterior predictive assessments to evaluate model fit in multilevel logistic regression (2009)
Journal Article
Green, M. J., Medley, G. F., & Browne, W. J. (2009). Use of posterior predictive assessments to evaluate model fit in multilevel logistic regression. Veterinary Research, 40(4), Article Article 30. https://doi.org/10.1051/vetres/2009013

Assessing the fit of a model is an important final step in any statistical analysis, but this is not straightforward when complex discrete response models are used. Cross validation and posterior predictions have been suggested as methods to aid mode... Read More about Use of posterior predictive assessments to evaluate model fit in multilevel logistic regression.

Cow, farm, and herd management factors in the dry period associated with raised somatic cell counts in early lactation (2008)
Journal Article
Green, M. J., Medley, G. F., Browne, W. J., & Bradley, A. J. (2008). Cow, farm, and herd management factors in the dry period associated with raised somatic cell counts in early lactation. Journal of Dairy Science, 91(4), https://doi.org/10.3168/jds.2007-0621

This study investigated cow characteristics, farm facilities, and herd management strategies during the dry period to examine their joint influence on somatic cell counts (SCC) in early lactation. Data from 52 commercial dairy farms throughout Englan... Read More about Cow, farm, and herd management factors in the dry period associated with raised somatic cell counts in early lactation.

Recognition and management of pain in cattle (2008)
Journal Article
Hudson, C., Whay, H., & Huxley, J. (2008). Recognition and management of pain in cattle. In Practice, 30(3), https://doi.org/10.1136/inpract.30.3.126

Attitudes towards pain and its control in farm animals have lagged behind those in companion animal species. However, a considerable amount of work over the past 15 years has focused on the perception of pain in cattle based on objective and subjecti... Read More about Recognition and management of pain in cattle.

Direct and indirect contacts between cattle farms in north-west England (2008)
Journal Article
Brennan, M. L., Kemp, R., & Christley, R. M. (in press). Direct and indirect contacts between cattle farms in north-west England. Preventive Veterinary Medicine, 84(3/4), https://doi.org/10.1016/j.prevetmed.2007.12.009

Little is known regarding the types and frequencies of contact that exist between farms and which of these may act as pathogen transmission routes; however it is likely that farms demonstrate considerable heterogeneity in such contacts. In this cross... Read More about Direct and indirect contacts between cattle farms in north-west England.

Cow, farm, and management factors during the dry period that determine the rate of clinical mastitis after calving (2007)
Journal Article
Green, M. J., Bradley, A. J., Medley, G. F., & Browne, W. J. (2007). Cow, farm, and management factors during the dry period that determine the rate of clinical mastitis after calving. Journal of Dairy Science, 90(8), https://doi.org/10.3168/jds.2007-0107

The purpose of the research was to investigate cow characteristics, farm facilities, and herd management strategies during the dry period to examine their joint influence on the rate of clinical mastitis after calving. Data were collected over a 2-yr... Read More about Cow, farm, and management factors during the dry period that determine the rate of clinical mastitis after calving.

Bacteriophage therapy to reduce Salmonella colonization of broiler chickens (2007)
Journal Article
Atterbury, R. J., Van Bergen, M., Ortiz, F., Lovell, M., Harris, J., De Boer, A., …Barrow, P. (2007). Bacteriophage therapy to reduce Salmonella colonization of broiler chickens. Applied and Environmental Microbiology, 73(14), https://doi.org/10.1128/AEM.00049-07

Acute enteric infections caused by salmonellas remain a major public health burden worldwide. Poultry, particularly chickens, are known to be the main reservoir for this zoonotic pathogen. Although some progress has been made in reducing Salmonella c... Read More about Bacteriophage therapy to reduce Salmonella colonization of broiler chickens.

CapA, an Autotransporter Protein of Campylobacter jejuni, Mediates Association with Human Epithelial Cells and Colonization of the Chicken Gut (2007)
Journal Article
Ashgar, S. S., Oldfield, N. J., Wooldridge, K. G., Jones, M. A., Irving, G. J., Turner, D. P., & Ala'Aldeen, D. A. (2007). CapA, an Autotransporter Protein of Campylobacter jejuni, Mediates Association with Human Epithelial Cells and Colonization of the Chicken Gut. Journal of Bacteriology, 189(5), 1856-1865. https://doi.org/10.1128/JB.01427-06

Two putative autotransporter proteins, CapA and CapB, were identified in silico from the genome sequence of Campylobacter jejuni NCTC11168. The genes encoding each protein contain homopolymeric tracts, suggestive of phase variation mediated by a slip... Read More about CapA, an Autotransporter Protein of Campylobacter jejuni, Mediates Association with Human Epithelial Cells and Colonization of the Chicken Gut.