All Outputs (6)

Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin (2021)
Journal Article
Al-Beltagi, S., Goulding, L. V., Chang, D. K., Mellits, K. H., Hayes, C. J., Gershkovich, P., …Chang, K. (2021). Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin. Virulence, 12(1), 2946-2956. https://doi.org/10.1080/21505594.2021.2006960

The struggle to control the COVID-19 pandemic is made challenging by the emergence of virulent SARS-CoV-2 variants. To gain insight into their replication dynamics, emergent Alpha (A), Beta (B) and Delta (D) SARS-CoV-2 variants were assessed for thei... Read More about Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin.

H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans (2021)
Journal Article
Li, F., Liu, J., Yang, J., Sun, H., Jiang, Z., Wang, C., …Sun, H. (2021). H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans. PLoS Pathogens, 17(12), Article e1010098. https://doi.org/10.1371/journal.ppat.1010098

H5N6 highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4 not only exhibits unprecedented intercontinental spread in poultry, but can also cause serious infection in humans, posing a public health threat. Phylogenetic analyses show that 40%... Read More about H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans.

IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection (2021)
Journal Article
Jiang, Z., Wei, F., Zhang, Y., Wang, T., Gao, W., Yu, S., …Liu, J. (2021). IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection. Nature Microbiology, 6, 932–945. https://doi.org/10.1038/s41564-021-00907-x

The retinoic acid-inducible gene I (RIG-I) receptor senses cytoplasmic viral RNA and activates type I interferons (IFN-I) and downstream antiviral immune responses. How RIG-I binds to viral RNA and how its activation is regulated remains unclear. Her... Read More about IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.

Reassortment with Dominant Chicken H9N2 Influenza Virus Contributed to the Fifth H7N9 Virus Human Epidemic (2021)
Journal Article
Pu, J., Yin, Y., Liu, J., Wang, X., Zhou, Y., Wang, Z., …Liu, J. (2021). Reassortment with Dominant Chicken H9N2 Influenza Virus Contributed to the Fifth H7N9 Virus Human Epidemic. Journal of Virology, 95(11), https://doi.org/10.1128/JVI.01578-20

Mink is a highly susceptible host species to circulating human and avian influenza viruses (2021)
Journal Article
Sun, H., Li, F., Liu, Q., Du, J., Liu, L., Li, C., …Liu, J. (2021). Mink is a highly susceptible host species to circulating human and avian influenza viruses. Emerging Microbes & Infections, 10(1), 472-480. https://doi.org/10.1080/22221751.2021.1899058

Pandemic influenza, typically caused by reassortment of human and avian influenza viruses, can result in severe or fatal infections in humans. Timely identification of potential pandemic viruses must be a priority in influenza virus surveillance. How... Read More about Mink is a highly susceptible host species to circulating human and avian influenza viruses.

Neurovirulence of avian influenza virus is dependent on the interaction of viral NP protein with host factor FMRP in the murine brain (2021)
Journal Article
Zhang, X., Pu, J., Sun, Y., Bi, Y., Jiang, Z., Xu, G., …Sun, H. (2021). Neurovirulence of avian influenza virus is dependent on the interaction of viral NP protein with host factor FMRP in the murine brain. Journal of Virology, 95(7), https://doi.org/10.1128/JVI.01272-20

Avian influenza viruses (AIVs) are zoonotic viruses that exhibit a range infectivity and severity in the human host. Severe human cases of AIVs infection are often accompanied by neurological symptoms, however, the factors involved in the infection o... Read More about Neurovirulence of avian influenza virus is dependent on the interaction of viral NP protein with host factor FMRP in the murine brain.